A Comparison of Central Venous Pressure Changes in the Third Stage of Labour Following Oxytocic Drugs and Diazepam

Haemodynamic Effects of Oxytocin (Syntocinon®) and Methyl Ergometrine (Methergin®) on the Systemic and Pulmonary Circulations of Pregnant Anaesthetized Women

“…It has been demonstrated that methyl ergometrine raises the central venous pressure and reduces peripheral venous compliance in healthy volunteers (6,9,23). Our results confirmed that a slight elevation in systemic blood pressure occurs after methyl ergometrine (8,21).…”

“…Anaesthesia does not appear to influence the circulatory effect of oxytocin to any great extent ( 2 , 5). Ergometrine has been shown to increase the systemic and the central venous pressures (6, 9,10,23,24), but its synthetic analogue methyl ergometrine (Methergin) has been reported to produce much less hypertension (8, 21). The purpose of this investigation was to study the cardiovascular effects of oxytocin (Syntocinon) and methyl ergometrine (Methergin) on the pulmonary circulation, and further, to com-pare the changes with those found in the systemic circulation.…”

Effects of methylergometrine and oxytocin on thoracic epidural pressure during cesarean section

“…Although the heart rate decreased after spinal anesthesia in both groups, it increased after oxytocin was administered. The changes in heart rate and mean blood pressure that we measured were in accordance with previous reports 14,15 , 17,20 , 21,23 even though cardiac output and vascular resistance were not measured in our study.…”

“…Both ergometrine and oxytocin can increase central venous pressure by augmenting uterine contraction. However, ergometrine's effect on central venous pressure is longer lived than oxytocin's effect 20,21 . This might explain why ergometrine caused a longer lasting increase in epidural pressure compared with oxytocin.…”