A comparison of cancer stem cell markers and nonclassical major histocompatibility complex antigens in colorectal tumor and noncancerous tissues

Özdemir, Rabia Bilge Özgül; Özdemir, Alper Tunga; Oltulu, Fatih; Kurt, Kamile; Yiğittürk, Gürkan; Kırmaz, Cengiz

doi:10.1016/j.anndiagpath.2016.09.012

Cited by 24 publications

(11 citation statements)

References 38 publications

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“…Additionally, HLA-G expression has been demonstrated to be involved in viral infection, organ transplantation, inflammatory reactions, autoimmune diseases and cancer, primarily serving an immune inhibitory function. Up to now, numerous researchers reported that the presence of HLA-G in numerous cancer types, including NSCLC and leukemia, is correlated with poor prognosis (15-17). ILT4/HLA-G has been investigated as an inhibitory axis in simian immunodeficiency virus and human immunodeficiency virus infections, recurrent implantation failure and systemic lupus erythematosus (18-20).…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer

et al. 2019

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Immunoglobulin like transcript (ILT) 4, a negative regulator of immune response in allograft rejection, autoimmunity and infectious diseases, has recently been determined to serve important roles in tumor development. In the present study, the co expression of ILT4 and human leukocyte antigen G (HLA-G) in tissues of human primary colorectal cancer (CRC) was revealed, and its association with older age, advanced stage, regional lymph node involvement and poor overall survival time was identified. In CRC cell lines, ILT4 and HLA-G co expression and their autocrine regulation was demonstrated. ILT4 interference affected HLA-G expression and regulated the cell proliferation, invasion and migration of CRC. HLA-G fusion protein treatment also increased ILT4 expression in a dose dependent manner, thereby activating protein kinase B (AKT) and extracellular signal regulated kinase (ERK) signaling, and facilitating the proliferation, migration and invasion of CRC cells. Additionally, the AKT and ERK activation, and CRC cell malignant characteristics induced by HLA-G may be suppressed by blocking ILT4. The present results indicated that the interaction of ILT4 and its ligand HLA-G promotes CRC progression through AKT and ERK signal activation, providing a novel strategy of blocking ILT4/HLA-G for the treatment of CRC.

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Section: Introductionmentioning

confidence: 99%

Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer

et al. 2019

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“…Advance in diagnosis and treatment of colorectal cancer (CRC) is not well translated into a favorable clinical outcome, and the disease-free survival of CRC remains poor [ 1 ]. A critical challenge in management of colorectal cancer is metastasis and relapse of the disease [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Cancer stem cells in progression of colorectal cancer

et al. 2017

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Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a critical role in the metastasis and relapse of colorectal cancer. CSCs are a subpopulation of cancer cells with unique properties of self-renewal, infinite division and multi-directional differentiation potential. Colorectal CSCs are defined with a group of cell surface markers, such as CD44, CD133, CD24, EpCAM, LGR5 and ALDH. They are highly tumorigenic, chemoresistant and radioresistant and thus are critical in the metastasis and recurrence of colorectal cancer and disease-free survival. This review article updates the colorectal CSCs with a focus on their role in tumor initiation, progression, drug resistance and tumor relapse.

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“…In vitro studies have shown that most CSCs share expression patterns of specific molecules such as CD133, CD44, ALDH, Sox2, Nanog, and Oct4 (1)(2)(3)25).…”

Section: Discussionmentioning

confidence: 99%

The Expressions of Cancer Stem Cell Markers and Nonclassical HLA antigens in Breast Tumors

Özdemir¹,

Özdemir²,

Oltulu³

et al. 2017

Istanbul Med J

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A comparison of cancer stem cell markers and nonclassical major histocompatibility complex antigens in colorectal tumor and noncancerous tissues

Cited by 24 publications

References 38 publications

Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer

Immunoglobulin‑like transcript 4 and human leukocyte antigen‑G interaction promotes the progression of human colorectal cancer

Cancer stem cells in progression of colorectal cancer

The Expressions of Cancer Stem Cell Markers and Nonclassical HLA antigens in Breast Tumors

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