A comparison of bone quality and its determinants in young opioid-dependent women with healthy control group

Effect of Eight-Month Exercise Intervention on Bone Outcomes of Young Opioid-Dependent Women

“…These participants would take medical examination and the questionnaire-based interviews, the exclusion criteria reduced the number of potential participants to 146. Exclusion criteria were: 1) signi cantly impaired renal or hepatic function, or chronic kidney disease; 2) Individuals with history of fractures in previous 24 months; 3) type 1 diabetes; 4) HIV infection; 5) pregnancy, because of the altered hormonal household (Ding et al, 2017). Patients refusing to follow-up in our study or who had withdrawn consent were also excluded.…”

“…Patients refusing to follow-up in our study or who had withdrawn consent were also excluded. Finally, according to the conducting power calculation, a total of 113 patients aged 20-40 years were recruited (Ding et al, 2017).…”

“…Body height (BH) was measured to the nearest 0.1 cm using a stadiometer (GMCS-I, XinDongHuaTeng Corp., China). Body weight, FFM, and fat mass (FM) were measured by bioelectrical impedance analyzer (BX-BCA-100, Broshare Technology Corp., Hefei, China) (Ding et al, 2017), and the REG. NO.…”

“…Long-term opioid dependence in young person will lead to drug-induced osteoporosis. Those drugs will affects bone metabolism and reduced trabecular bone mass, or suppress hypothalamic secretion of gonadotropin-releasing hormone and consequently decreases the level of gonadal hormones and lead to low bone quality and later-life osteoporosis (Ding et al, 2017;Gotthardt et al, 2016). Osteoporosis is an age-related disease, characterized by a progressive loss of bone quality and micro-architectural deterioration, predisposing to fracture after minimal trauma or fall (Harvey et al, 2014).…”

“…However, it's uncertain that if the changes of FFM was the determinant of changes of bone quality. We had put forward a research hypothesis that increasing the degree of FFM through special physical training program could be a treatment for improving the bone health of women with drug addiction in our previous study (Ding et al, 2017).…”