A Comparison of Blood Amino Acid Concentrations Following Ingestion of Rice and Whey Protein Isolate A Double-Blind Crossover Study

Purpura, Martin; Rp, Lowery; Jm, Joy; Eo, De Souza; Ds, Kalman; Jäger, Ralf; Jm, Wilson

doi:10.15744/2393-9060.1.306

Cited by 7 publications

(2 citation statements)

References 25 publications

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“…Target cells will only be exposed to whey components arriving in the bloodstream from the gut. Bovine WP are easily and rapidly digested to individual AA in the gastrointestinal tract, showing maximum concentration of total AA in plasma at 69 min post-WPI consumption (Purpura et al, 2014). Indeed, WPI has a digestible indispensable AA score of 1.09 (Rutherfurd et al, 2015).…”

Section: Can Whey Products Boost Intracellular Antioxidant Defenses In Vitro?mentioning

confidence: 99%

Invited review: Whey proteins as antioxidants and promoters of cellular antioxidant pathways

Corrochano

Buckin

Kelly

et al. 2018

Journal of Dairy Science

114

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Oxidative stress contributes to cell injury and aggravates several chronic diseases. Dietary antioxidants help the body to fight against free radicals and, therefore, avoid or reduce oxidative stress. Recently, proteins from milk whey liquid have been described as antioxidants. This review summarizes the evidence that whey products exhibit radical scavenging activity and reducing power. It examines the processing and treatment attempts to increase the antioxidant bioactivity and identifies 1 enzyme, subtilisin, which consistently produces the most potent whey fractions. The review compares whey from different milk sources and puts whey proteins in the context of other known food antioxidants. However, for efficacy, the antioxidant activity of whey proteins must not only survive processing, but also upper gut transit and arrival in the bloodstream, if whey products are to promote antioxidant levels in target organs. Studies reveal that direct cell exposure to whey samples increases intracellular antioxidants such as glutathione. However, the physiological relevance of these in vitro assays is questionable, and evidence is conflicting from dietary intervention trials, with both rats and humans, that whey products can boost cellular antioxidant biomarkers.

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Section: Can Whey Products Boost Intracellular Antioxidant Defenses In Vitro?mentioning

confidence: 99%

Invited review: Whey proteins as antioxidants and promoters of cellular antioxidant pathways

Corrochano

Buckin

Kelly

et al. 2018

Journal of Dairy Science

114

View full text Add to dashboard Cite

show abstract

“…Essential amino acids (EAA) function to reduce muscle inflammation after strenuous exercise. Purpura et al (2014) observed that consumption of 48 g of commercial whey protein isolate (WPI) resulted in 229.5 nmol EAA/mL plasma in 10 resistance-trained men 67 min later. Bioactive peptides derived from whey proteins, if bioavailable, may also play a role in muscle health as suggested by in vitro data using whey hydrolysates directly on the C2C12 muscle cell line, for instance, activating the rapamycin complex I (Roeseler et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Bovine whey peptides transit the intestinal barrier to reduce oxidative stress in muscle cells

et al. 2019

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Health benefits are routinely attributed to whey proteins, their hydrolysates and peptides based on in vitro chemical and cellular assays. The objective of this study was to track the fate of whey proteins through the upper gastrointestinal tract, their uptake across the intestinal barrier and then assess the physiological impact to downstream target cells. Simulated gastrointestinal digestion (SGID) released a selection of whey peptides some of which were transported across a Caco-2/HT-29 intestinal barrier, inhibited free radical formation in muscle and liver cells. In addition, SGID of β-lactoglobulin resulted in the highest concentration of free amino acids (176 nM) arriving on the basolateral side of the co-culture with notable levels of branched chain and sulphur-containing amino acids. In vitro results indicate that consumption of whey proteins will deliver bioactive peptides to target cells.

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Plant-based food patterns to stimulate muscle protein synthesis and support muscle mass in humans: a narrative review

Nichele

Phillips

Boaventura

2022

Appl. Physiol. Nutr. Metab.

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The interest in a diet with a higher proportion of plant-based foods to animal-based foods is a global food pattern trend. However, there are concerns regarding adopting plants as the main dietary protein source to support muscle protein synthesis and muscle mass. These concerns are centred on three issues: lower protein bioavailability due to antinutritional compounds in plants, lower per-serve scores of protein at similar energy intake, and amino acid scores of plants being lower than optimal. We aimed here to synthesize and discuss evidence around plant protein in human nutrition focusing on the capacity of these proteins to stimulate muscle protein synthesis as a key part of gaining or maintaining muscle mass. In this review, we address the issues of plant protein quality and provide evidence for how plant proteins can be made more effective to stimulate muscle protein synthesis and support muscle mass in partial or total replacement of consumption of products of animal origin. Novelty: ● Plant proteins are known, in general, to have lower protein quality scores than animal proteins, and this may have important implications, especially for those aiming to increase their skeletal muscle mass through exercise. ● A plant-based diet has been postulated to have lower protein quality limiting MPS responses and potentially compromising exercise-induced gains in muscle mass. ● Current evidence shows that plant proteins can stimulate MPS, as can whole foods, especially when combining food groups, increasing portion sizes, and optimizing amino acid bioavailability through processing or common preparation methods.

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A Comparison of Blood Amino Acid Concentrations Following Ingestion of Rice and Whey Protein Isolate A Double-Blind Crossover Study

Cited by 7 publications

References 25 publications

Invited review: Whey proteins as antioxidants and promoters of cellular antioxidant pathways

Invited review: Whey proteins as antioxidants and promoters of cellular antioxidant pathways

Bovine whey peptides transit the intestinal barrier to reduce oxidative stress in muscle cells

Plant-based food patterns to stimulate muscle protein synthesis and support muscle mass in humans: a narrative review

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