A comparison of biomechanical properties between human and porcine cornea

Zeng, Yanjun; Yang, Jimin; Huang, Kun; Lee, Zhihui; Lee, Xiuyun

doi:10.1016/s0021-9290(00)00219-0

Cited by 279 publications

(219 citation statements)

References 5 publications

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“…The research has concentrated on porcine corneas because of their close similarity with human corneas in structure and constitutive relationship (Zeng et al 2001). This work has enabled the identification of important aspects of the material properties and the determination of the significant factors that should be considered in the numerical modelling.…”

Section: Introductionmentioning

confidence: 99%

Application of structural analysis to the mechanical behaviour of the cornea

Anderson

Elsheikh

Newson

2004

J. R. Soc. Interface.

174

128

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Structural engineering analysis tools have been used to improve the understanding of the biomechanical behaviour of the cornea. The research is a multi-disciplinary collaboration between structural engineers, mathematical and numerical analysts, ophthalmologists and clinicians. Mathematical shell analysis and nonlinear finite-element modelling have been used in conjunction with laboratory experiments to study the behaviour of the cornea under different loading states and to provide improved predictions of the mechanical response to disease and injury. The initial study involved laboratory tests and mathematical back analysis to determine the corneal material properties and topography. These data were then used to facilitate the construction of accurate finite-element models that are able to reliably trace the performance of cornea upon exposure to disease, injury or elevated intra-ocular pressure. The models are being adapted to study the response to keratoconus (a disease causing loss of corneal tissue) and to tonometry procedures, which are used to measure the intra-ocular pressure. This paper introduces these efforts as examples of the application of structural engineering analysis tools and shows their potential in the field of corneal biomechanics.

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Section: Introductionmentioning

confidence: 99%

Application of structural analysis to the mechanical behaviour of the cornea

Anderson

Elsheikh

Newson

2004

J. R. Soc. Interface.

174

128

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“…The uniaxial tensile tests are done using rectangular corneal strips subjected to tensile loading [1][2][3][4][5][6][7][8]. Because of the well-known limitations of this testing technique [9], it has often been used for comparative studies [3,6,10].…”

Section: Introductionmentioning

confidence: 99%

“…Because of the well-known limitations of this testing technique [9], it has often been used for comparative studies [3,6,10]. Compared to the uniaxial testing technique, inflation tests are able to better represent natural conditions of the cornea as they do not use excised samples [11,12].…”

Section: Introductionmentioning

confidence: 99%

Biomechanical Properties of Corneal Extracellular Matrix Using Experimental and Computational Methods

Hatami-Marbini¹

2016

Proceedings of the VII European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS Congress 2016)

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“…Previous studies on cornea mechanics have typically employed a tensile strip method [64,3,35,45,89,86], or a more physiologically relevant inflation method [88,44,34,77]. These measurements have been used, for example, to study the efficacy of cross-linking agents as means to counteract keratoconous [86,80].…”

Section: Introductionmentioning

confidence: 99%

“…While previous work both at Sandia and in the literature [15,64,3,35,80,45,89,86], has primarily involved tensile tests of excised corneal strips, both the excision process and the uniaxial loading mode may produce results that are not physiologically meaningful. Specifically, the excision process severs off-axis collagen fibrils, and the subsequent tensile loading mode will only directly load the on-axis fibrils.…”

Section: Introductionmentioning

confidence: 99%

The mechanics of soft biological composites.

Nguyen

Grazier²,

Boyce³

et al. 2007

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Biological tissues are uniquely structured materials with technologically appealing properties. Soft tissues such as skin, are constructed from a composite of strong fibrils and fluid-like matrix components. This was the first coordinated experimental/modeling project at Sandia or in the open literature to consider the mechanics of micromechanically-based anisotropy and viscoelasticity of soft biological tissues. We have exploited and applied Sandia's expertise in experimentation and mechanics modeling to better elucidate the behavior of collagen fibril-reinforced soft tissues.The purpose of this project was to provide a detailed understanding of the deformation of ocular tissues, specifically the highly structured skin-like tissue in the cornea. This discovery improved our knowledge of soft/complex materials testing and modeling. It also provided insight into the way that cornea tissue is bio-engineered such that under physiologically-relevant conditions it has a unique set of properties which enhance functionality. These results also provide insight into how non-phsyiologic loading conditions, such as corrective surgeries, may push the cornea outside of its natural design window, resulting in unexpected non-linear responses. Furthermore, this project created a clearer understanding of the mechanics of soft tissues that could lead to bio-inspired materials, such as highly supple and impact resistant body armor, and improve our design of human-machine interfaces, such as micro-electricalmechanical (MEMS) based prosthetics. Through this study,

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A comparison of biomechanical properties between human and porcine cornea

Cited by 279 publications

References 5 publications

Application of structural analysis to the mechanical behaviour of the cornea

Application of structural analysis to the mechanical behaviour of the cornea

Biomechanical Properties of Corneal Extracellular Matrix Using Experimental and Computational Methods

The mechanics of soft biological composites.

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