A Comparison of Bimatoprost 0.03% Versus the Fixed-Combination of Latanoprost 0.005% and Timolol 0.5% in Adult Patients With Elevated Intraocular Pressure: An Eight-Week, Randomized, Open-Label Trial

Abstract

The fixed combination of latanoprost/timolol was significantly superior to bimatoprost alone in reducing IOP in patients with POAG or OHT. Further studies with large sample sizes should be taken to support the superior efficacy of latanoprost/timolol, as well as to better assess its profile of side effects.

Reproducibility of intraocular pressure peak and fluctuation of the water‐drinking test

“…Studies have shown that the WDT may be used as a surrogate for detecting patients who have intraocular pressure (IOP) spikes not identified during office hours . The WDT has also been used to evaluate the effect of treatment on reducing IOP peak and fluctuation, both with ocular hypotensive medications and filtering surgery . Also, the peak of the WDT correlates with the severity of glaucoma, and a patients’ response to the WDT may be predictive of visual field progression …”

Applications of the water drinking test in glaucoma management

“…This may be an alternative explanation for the results of LoGTS, in which, despite its limitations, especially regarding the highest dropout rate in the brimonidine group, similar IOP (single measurements) were obtained in both groups, whereas the rate of visual field progression was higher in the timolol group. Other studies compare the efficacy of IOP reduction between drugs or the benefit of adding drugs to a pre‐existing therapeutic regimen and the mechanisms of action of hypotensive medications …”

“…Recently, this test was revived with a new focus: as a surrogate marker for outflow facility reserve to detect IOP instability and to estimate IOP peak pressure. Peak IOP elicited by this test may be an indicator for the likelihood of progression and efficacy of hypotensive drugs . Its potential was highlighted in the findings of the collaborative glaucoma study in which 5886 eyes without glaucoma were followed for up to 13 years.…”

“…Peak IOP elicited by this test may be an indicator for the likelihood of progression 15,16 and efficacy of hypotensive drugs. [17][18][19][20][21] Its potential was highlighted in the findings of the collaborative glaucoma study 22 in which 5886 eyes without glaucoma were followed for up to 13 years. Among the risk factors identify for new onset glaucoma, a WDT response exceeding 5 mmHg was associated with a sixfold increased risk compared with those with a WDT response less than 1 mmHg.…”

Reprodutibilidade do teste de sobrecarga hídrica em portadores de glaucoma de ângulo aberto sob tratamento clínico

“…Essa pode ser uma explicação alternativa para os resultados do estudo LoGTS (44) em que, apesar das suas limitações, especialmente no que se refere à maior taxa de abandono no grupo brimonidina, foram obtidos valores de PIO semelhantes (em medidas isoladas) em ambos os grupos, enquanto a taxa de progressão do campo visual foi maior no grupo tratado com timolol. Outros estudos compararam a eficácia da redução da PIO entre fármacos ou o benefício de adicionar fármacos a um regime terapêutico pré-existente e os mecanismos de ação dos medicamentos hipotensores (45,46,9,47) . A isso podemos acrescentar os achados de Waisbourd et al (48) O TSH foi realizado como se segue: a PIO foi medida antes da ingestão de água (PIO basal) e após o paciente beber 800 ml de água da torneira em menos de cinco minutos (49) .…”