A comparison of associations of alanine aminotransferase and gamma-glutamyltransferase with fasting glucose, fasting insulin, and glycated hemoglobin in women with and without diabetes

Fraser, Abigail; Ebrahim, Shah; Smith, George Davey; Lawlor, Debbie A.

doi:10.1002/hep.21667

Cited by 64 publications

(43 citation statements)

References 45 publications

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“…As a result, two predictive factors that correlate with fibrosis stage (platelet counts and AFP) were selected in the model, and three probability groups reflected the different distribution of fibrosis stage. GGT is reported to be associated with insulin resistance and hepatic steatosis [34][35][36][37], a factor that confers resistance to IFN therapy [38][39][40][41][42][43][44]. What is unique to the present study is the visualization of response probability by combining these factors and its high reproducibility revealed by a high-quality validation of the model by internal and external validation datasets that were completely independent of the model building dataset.…”

Section: Discussionmentioning

confidence: 77%

Pretreatment prediction of response to peginterferon plus ribavirin therapy in genotype 1 chronic hepatitis C using data mining analysis

et al. 2010

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Section: Discussionmentioning

confidence: 77%

Pretreatment prediction of response to peginterferon plus ribavirin therapy in genotype 1 chronic hepatitis C using data mining analysis

et al. 2010

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“…We found evidence of positive associations between sex (male compared to female), waist circumference, BMI, Mexican ethnic origin, and C-reactive protein and elevated ALT, and weaker evidence that fasting insulin, triglycerides, and poverty were associated with elevated ALT, findings that are consistent with other studies in both general 12, 13, 34 and select adolescent populations, 14, 36, 38 as well as in adult populations. 14,35,39,40 When associations of participants' characteristics were examined separately per ethnic group, no differences in the magnitude of associations were found. This finding is important since it suggests that although the prevalence of elevated ALT differed by ethnic group, greater waist circumference and/or BMI is detrimental among all ethnic groups.…”

Section: Discussionmentioning

confidence: 91%

Prevalence of Elevated Alanine Aminotransferase Among US Adolescents and Associated Factors: NHANES 1999–2004

2007

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Background & aims-Non-alcoholic fatty liver disease (NAFLD) is a common cause of liver disease in children and adolescents. The majority of studies of NAFLD in children have been in select populations of the clinically obese. Study aims were to estimate the prevalence of elevated alanineaminotransferase (ALT, as a marker of NAFLD) in a general contemporary adolescent population and to identify leading risk factors for ALT elevation (> 30 U/L). Conclusions-ALT is associated with waist circumference and insulin resistance even in a young population. These characteristics could be utilized to identify adolescents who may benefit from screening for NAFLD, offering an opportunity to prevent disease progression at an early age. Methods-We

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“…A cross-sectional study found that individuals with ALT levels of >40 IU/L were at an increased risk of fatty liver compared with those with ALT levels of <40 IU/L (24). Another study (25) showed that serum ALT was a risk factor for NASH, which was diagnosed in 59% and 74% of the patients with normal and increased ALT, respectively (p=0.01). GGT activity is a sensitive marker of liver dysfunction (26).…”

Section: Discussionmentioning

confidence: 97%

The development of a clinical score for the prediction of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease using routine parameters

Li¹,

Jian-hui²,

Zhang³

et al. 2015

Turk J Gastroenterol

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Background/Aims: To develop a clinical score for the prediction of nonalcoholic steatohepatitis (NASH) using routine parameters in patients with nonalcoholic fatty liver disease who had abnormal liver function tests and/or fatty liver detected by ultrasonography. Materials and Methods: To identify parameters associated with the presence of NASH by evaluating anthropometric characteristics and routine biomarkers of 82 patients with histologically proven NAFLD and to develop a clinical score for predicting NASH according to the area under the curve of receiver operating characteristics (AUC) of parameters. Results: Four parameters [alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), C-reactive protein (CRP), and apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio] were significantly linked to NASH. The AUROCs of ALT, GGT, CRP, and ApoB/ApoA1 ratio for the prediction of NASH were 0.829, 0.892, 0.708, and 0.712, respectively. The AUROC of the combined clinical score for the prediction of NASH was 0.904 (95% CI, 0.885-1.002) at a cut-off of 3.8 points with a sensitivity of 90.2%, specificity of 87.0%, positive predictive value of 88.3%, and negative predictive value of 91.5%. Conclusion: In the present study, a clinical score was developed for the noninvasive prediction of NASH; the score was based on a combination of routine biochemical parameters and was useful in distinguishing NASH from NAFLD.

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A comparison of associations of alanine aminotransferase and gamma-glutamyltransferase with fasting glucose, fasting insulin, and glycated hemoglobin in women with and without diabetes

Cited by 64 publications

References 45 publications

Pretreatment prediction of response to peginterferon plus ribavirin therapy in genotype 1 chronic hepatitis C using data mining analysis

Pretreatment prediction of response to peginterferon plus ribavirin therapy in genotype 1 chronic hepatitis C using data mining analysis

Prevalence of Elevated Alanine Aminotransferase Among US Adolescents and Associated Factors: NHANES 1999–2004

The development of a clinical score for the prediction of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease using routine parameters

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