A comparison of antiepileptic drug therapy in patients with severe intellectual disability and patients with normal intellect

Fridhandler, Jonathan; Coelho, Fernando Morgadinho Santos; Tai, Peter; Andrade, Danielle M.

doi:10.1016/j.yebeh.2012.07.029

Cited by 5 publications

(9 citation statements)

References 37 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other AEDs that are associated with such behavioral side effects in persons without ID, for instance, zonisamide or perampanel, can cause these effects in persons with ID, although no clinical trial data specific to people with ID and epilepsy exist. High drug load may also be associated with negative behavioral changes and is frequent in persons with epilepsy and ID 25. Older AEDs (e.g., primidone and phenobarbital) may also have behavioral side effects, including when drug withdrawal is tried.…”

Section: Behavioral Side Effects Of Antiepileptic Drugsmentioning

confidence: 99%

See 1 more Smart Citation

Behavioral disorder in people with an intellectual disability and epilepsy: A report of the Intellectual Disability Task Force of the Neuropsychiatric Commission of ILAE

et al. 2016

View full text Add to dashboard Cite

SummaryThe management and needs of people with intellectual disability (ID) and epilepsy are well evidenced; less so, the comorbidity of behavioral disorder in this population. “Behavioral disorder” is defined as behaviors that are difficult or disruptive, including stereotypes, difficult or disruptive behavior, aggressive behavior toward other people, behaviors that lead to injury to self or others, and destruction of property. These have an important link to emotional disturbance. This report, produced by the Intellectual Disability Task Force of the Neuropsychiatric Commission of the ILAE, aims to provide a brief review of some key areas of concern regarding behavioral disorder among this population and proposes a range of research and clinical practice recommendations generated by task force members. The areas covered in this report were identified by experts in the field as being of specific relevance to the broad epilepsy community when considering behavioral disorder in persons with epilepsy and ID; they are not intended to be exhaustive. The practice recommendations are based on the authors’ review of the limited research in this field combined with their experience supporting this population. These points are not graded but can be seen as expert opinion guiding future research and clinical practice.

show abstract

Section: Behavioral Side Effects Of Antiepileptic Drugsmentioning

confidence: 99%

“…High drug load may also be associated with negative behavioral changes and is frequent in persons with epilepsy and ID. 25 Older AEDs (e.g., primidone and phenobarbital) may also have behavioral side effects, including when drug withdrawal is tried.…”

Section: Behavioral Side Effects Of Antiepileptic Drugsmentioning

confidence: 99%

Behavioral disorder in people with an intellectual disability and epilepsy: A report of the Intellectual Disability Task Force of the Neuropsychiatric Commission of ILAE

et al. 2016

View full text Add to dashboard Cite

show abstract

“…There were three articles based on retrospective review of varied data sources (Fridhandler et al . ; Kiani et al . ; Hom et al .…”

Section: Resultsmentioning

confidence: 99%

“…, ) and one each from Belgium (Peeters ), Canada (Fridhandler et al . ) and Ireland (McCarron et al . ).…”

Section: Resultsmentioning

confidence: 99%

Service Responses to People with Intellectual Disabilities and Epilepsy: A Systematic Review

Robertson

Baines

Emerson

et al. 2015

Research Intellect Disabil

View full text Add to dashboard Cite

show abstract

“…Although highly heterogeneous in presentation, etiology, and affected cell populations, neurological disorders fundamentally involve the loss of proper circuit function (Figure 1) (Miller et al, 2011; Noutel et al, 2011; Ramamoorthi and Lin, 2011; Wang et al, 2011; Wesson et al, 2011; Ghiglieri et al, 2012). In recent times, pharmacological interventions have shown therapeutic promise toward the treatment of many neurological disorders (Kraft et al, 2009; Ballatore et al, 2012; Das et al, 2012; Fridhandler et al, 2012; Pedersen et al, 2012; Weaver et al, 2012). For example, several forms of epilepsy can be well controlled with pharmacology.…”

Section: Introductionmentioning

confidence: 99%

Genetic strategies to investigate neuronal circuit properties using stem cell-derived neurons

Garcia¹,

Kim²,

Arenkiel³

2012

Front. Cell. Neurosci.

View full text Add to dashboard Cite

The mammalian brain is anatomically and functionally complex, and prone to diverse forms of injury and neuropathology. Scientists have long strived to develop cell replacement therapies to repair damaged and diseased nervous tissue. However, this goal has remained unrealized for various reasons, including nascent knowledge of neuronal development, the inability to track and manipulate transplanted cells within complex neuronal networks, and host graft rejection. Recent advances in embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) technology, alongside novel genetic strategies to mark and manipulate stem cell-derived neurons, now provide unprecedented opportunities to investigate complex neuronal circuits in both healthy and diseased brains. Here, we review current technologies aimed at generating and manipulating neurons derived from ESCs and iPSCs toward investigation and manipulation of complex neuronal circuits, ultimately leading to the design and development of novel cell-based therapeutic approaches.

show abstract

A comparison of antiepileptic drug therapy in patients with severe intellectual disability and patients with normal intellect

Cited by 5 publications

References 37 publications

Behavioral disorder in people with an intellectual disability and epilepsy: A report of the Intellectual Disability Task Force of the Neuropsychiatric Commission of ILAE

Behavioral disorder in people with an intellectual disability and epilepsy: A report of the Intellectual Disability Task Force of the Neuropsychiatric Commission of ILAE

Service Responses to People with Intellectual Disabilities and Epilepsy: A Systematic Review

Genetic strategies to investigate neuronal circuit properties using stem cell-derived neurons

Contact Info

Product

Resources

About