A comparison of ampicillin, erythromycin and erythromycin with sulphametopyrazine in the treatment of infective exacerbations of chronic bronchitis

Willey, R F; Gould, J. C.; GRANT, I

doi:10.1016/s0007-0971(78)80038-2

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus rather than citing evidence from placebo-controlled trials, they referred to the in-vitro activity of antibiotics (for example [ 18 , 19 ]). Yet another group of head-to-head trials referred to placebo-controlled trials to justify their head-to-head trials but selectively cited only those trials with positive results [ 20 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

Where is the supporting evidence for treating mild to moderate chronic obstructive pulmonary disease exacerbations with antibiotics? A systematic review

Puhan

Vollenweider

Steurer

et al. 2008

BMC Med

View full text Add to dashboard Cite

Background: Randomised trials comparing different drugs head-to-head are extremely valuable for clinical decision-making. However, it is scientifically and ethically sensible to demand strong evidence that a drug is effective by showing superiority over a placebo before embarking on head-to-head comparisons of potentially ineffective drugs. Our aim was to study the evolvement of evidence from placebo-controlled and head-to-head trials on the effects of antibiotics for the treatment of mild to moderate exacerbations of chronic obstructive pulmonary disease.

show abstract

Section: Resultsmentioning

confidence: 99%

Where is the supporting evidence for treating mild to moderate chronic obstructive pulmonary disease exacerbations with antibiotics? A systematic review

Puhan

Vollenweider

Steurer

et al. 2008

BMC Med

View full text Add to dashboard Cite

show abstract

“…Macrolides are a widely used class of antibiotics that still play an important role in the chemotherapy of infectious airway diseases 7,8 . The mechanism of their antimicrobial activity is based on inhibition of bacterial protein synthesis.…”

Section: Introductionmentioning

confidence: 99%

Macrolides attenuate mucus hypersecretion in rat airways through inactivation of NF‐κB

Feng

Wen

et al. 2008

Respirology

View full text Add to dashboard Cite

show abstract

“…The macrolide antibiotic erythromycin has been shown to be effective in the treatment of patients with acute bronchitis and chronic airway diseases including asthma and chronic bronchitis [ 4,5]. The efficacy of this antibiotic can be attributed not only to its antimicrobial activities but also to its immunomodulatory action on neutrophils and macrophages [6,7].…”

mentioning

confidence: 99%

Erythromycin inhibits Cl secretion across canine tracheal epithelial cells

Tamaoki¹,

Isono²,

Sakai³

et al. 1992

Eur Respir J

View full text Add to dashboard Cite

We studied the effect of the macrolide antibiotic erythromycin on bioelectrical properties of canine cultured tracheal epithelium under short-circuit conditions in vitro. Addition of erythromycin to the submucosal but not to the mucosal side dose-dependently decreased short-circuit current (Isc), the maximal decrease from the baseline value and the concentration required to produce a half-maximal effect (IC50) being 5.6 +/- 1.0 microA.cm-2 (mean +/- SE, p less than 0.001) and 18 microM, respectively. In contrast, other antibiotics including ampicillin, cephazolin and tetracycline were without effect. The erythromycin-induced decrease in Isc was not altered by amiloride, but it was abolished by bumetanide, diphenylamine-2-carboxylate2, and substitution of Cl in the bathing medium with gluconate (p less than 0.001, in each case). The effect of erythromycin on epithelial Isc was attenuated by pretreatment of cells with indomethacin but not with AA-861 a lipoxygenase inhibitor. Incubation of cells with erythromycin inhibited the release of prostaglandins E2 and F2 alpha from tracheal epithelial cells. These results indicate that erythromycin may selectively inhibit Cl secretion across airway epithelium through the inhibition of prostaglandin synthesis and suggest that this action possibly reflects its clinical efficacy in the treatment of airway hypersecretion.

show abstract

A comparison of ampicillin, erythromycin and erythromycin with sulphametopyrazine in the treatment of infective exacerbations of chronic bronchitis

Cited by 3 publications

References 0 publications

Where is the supporting evidence for treating mild to moderate chronic obstructive pulmonary disease exacerbations with antibiotics? A systematic review

Where is the supporting evidence for treating mild to moderate chronic obstructive pulmonary disease exacerbations with antibiotics? A systematic review

Macrolides attenuate mucus hypersecretion in rat airways through inactivation of NF‐κB

Erythromycin inhibits Cl secretion across canine tracheal epithelial cells

Contact Info

Product

Resources

About