A comparison of adrenalin and glucagon effects on carbohydrate levels of larval and adult Rana pipiens

Abstract

Hyperglycemia was observed in frogs after single ip injections of doses above 50 &kg of adrenalin and glucagon. Blood glucose responses were maximal at 3 hr and lasted at least 5 hr. Lactacidemia was apparent after treatment with adrenalin at doses of 50 &kg and above. The increase in lactate was apparent by 1 hr and had dropped to control levels by 5 hr. Tissue giycogen loss was not observed after treatment with either hormone in adults. Preliminary studies with tadpoles indicated a hyperglycemic response to adrenalin and glucagon at doses of 1.0 mgikg and an increase in lactate after injection of a 1 .O mg/kg dose of adrenalin. Liver glycogen loss was observed following glucagon but not adrenalin. Both hormones stimulated glucose release from liver slices of frogs and tadpoles.

The Role of Adrenergic Receptors in the Action of Adrenaline on Plasma Lactate, Glucose, Liver, and Skeletal Muscle Glycogen in the Common African Toad Bufo Regularis

“…The result of this study confirms the hyperglycemic effect of adrenaline in the common African toad. This is consistent with previous studies in mammals (Rizza et al, 1980;Sherwin and Sacca, 1984;Oyebola and Alada, 1993;Oyebola et al, 2011;, Dibe et al, 2020, and some amphibians (Farrar and Frye, 1977, 1979b, Herman, 1977, Oyebola et al, 1998. The findings of the present study in which adrenaline caused significant reduction in both the liver and gastrocnemius muscle glycogen seem to suggest that liver and skeletal muscle glycogen may have contributed to adrenaline hyperglycemia probably through glycogenolysis and gluconeogenesis.…”