A Comparison of Acute Toxicities Between Vertebral-Body-Sparing Proton Craniospinal Irradiation and Standard Photon CSI in Pediatric Patients

Hopper, Austin; Chou, B.; Elster, Jennifer; Guram, Kripa; Crawford, John R.; Murphy, Karen L.; Chang, A.L.; MacEwan, I.

doi:10.1016/j.ijrobp.2019.06.1163

Cited by 3 publications

(2 citation statements)

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“… 142 In the treatment of the spinal column, vertebral body sparing with proton radiotherapy reduced the rates of acute side effects including hematologic toxicities. 143 Vertebral body sparing also has the potential to reduce radiation dose to the growth plates, which may reduce risk for growth inhibition, without increasing risk of severe skeletal abnormalities. 144 , 145 There is retrospective data to suggest that vertebral body sparing may not increase risk of scoliosis compared to whole vertebral body irradiation at a median follow up at 19 month.…”

Section: Radiotherapy Techniquesmentioning

confidence: 99%

Precision based approach to tailoring radiotherapy in the multidisciplinary management of pediatric central nervous system tumors

Phuong

Qiu

Mueller

et al. 2023

Journal of the National Cancer Center

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Section: Radiotherapy Techniquesmentioning

confidence: 99%

Precision based approach to tailoring radiotherapy in the multidisciplinary management of pediatric central nervous system tumors

Phuong

Qiu

Mueller

et al. 2023

Journal of the National Cancer Center

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“…Proton craniospinal irradiation (pCSI) largely circumvents the issue of off-target radiation toxicity. The chief advantage of proton over proton radiation is the ability to conform to a narrower range of treatment depth without sacrificing treatment dose, thereby maximizing therapeutic effect and minimizing unintended side-scatter [ 34 , 35 ]. The safety of hypofractionated pCSI in adults with solid tumor LM has been recently demonstrated in a phase 1b dose-expansion trial [ 36 ].…”

Section: Radiation Therapymentioning

confidence: 99%

Leptomeningeal Metastases: New Opportunities in the Modern Era

Wilcox

Boire

2022

Neurotherapeutics

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Leptomeningeal metastases arise from cancer cell entry into the subarachnoid space, inflicting significant neurologic morbidity and mortality across a wide range of malignancies. The modern era of cancer therapeutics has seen an explosion of molecular-targeting agents and immune-mediated strategies for patients with breast, lung, and melanoma malignancies, with meaningful extracranial disease control and improvement in patient survival. However, the clinical efficacy of these agents in those with leptomeningeal metastases remains understudied, due to the relative rarity of this patient population, the investigational challenges associated with studying this dynamic disease state, and brisk disease pace. Nevertheless, retrospective studies, post hoc analyses, and small prospective trials in the last two decades provide a glimmer of hope for patients with leptomeningeal metastases, suggesting that several cancer-directed strategies are not only active in the intrathecal space but also improve survival against historical odds. The continued development of clinical trials devoted to patients with leptomeningeal metastases is critical to establish robust efficacy outcomes in this patient population, define drug pharmacokinetics in the intrathecal space, and uncover new avenues for treatment in the face of leptomeningeal therapeutic resistance.

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Normal tissue exposure and second malignancy risk in vertebral-body-sparing craniospinal irradiation

et al. 2022

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A Comparison of Acute Toxicities Between Vertebral-Body-Sparing Proton Craniospinal Irradiation and Standard Photon CSI in Pediatric Patients

Cited by 3 publications

References 0 publications

Precision based approach to tailoring radiotherapy in the multidisciplinary management of pediatric central nervous system tumors

Precision based approach to tailoring radiotherapy in the multidisciplinary management of pediatric central nervous system tumors

Leptomeningeal Metastases: New Opportunities in the Modern Era

Normal tissue exposure and second malignancy risk in vertebral-body-sparing craniospinal irradiation

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