A Comparison of Acute and Chronic Toxicity Profile Between Conventional and Hypofractionated Whole Breast Irradiation in Patients Undergoing Breast Conserving Surgery

Systematic review and meta-analysis comparing hypofractionated with conventional fraction radiotherapy in treatment of early breast cancer

“…Six RCTs reported the details about random sequence generation [11e14, 28,33], five RCTs unclear [19,22,23,31,32]. Seven RCTs reported adequate allocation concealment [11e14, 28,32,33], four RCTs unclear [19,22,23,31]. All RCTs were with low risks of incomplete outcome data.…”

“…All RCTs were with low risks of incomplete outcome data. Four RCTs were with unclear risks of reporting bias [19,22,23,32]. Blind method was not mentioned in all trials, however, this should unlikely affect the quality assessment results (Fig.…”