A comparison of abrasion burr arthroplasty and subchondral drilling in the treatment of full-thickness cartilage lesions in the rabbit

Menche, David; Frenkel, Sally R.; Blair, Benjamin; Watnik, Neil F.; Toolan, Brian C.; Yaghoubian, Robert; Pitman, Mark I.

doi:10.1016/s0749-8063(96)90059-6

Cited by 90 publications

(57 citation statements)

References 14 publications

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“…The defects of hyaline cartilage and the extensive defects of costal and auricular cartilages are usually filled up with fibrous connective tissue or fibrous cartilage, which both do not have adequate functional properties; that determines persistent attempts to find new possibilities for cartilage regeneration. The healing of cartilage defects can be improved with mechanical stimulation, intra-articular application of HA, hormone therapy, [38][39][40][41] and also with the use of osteochondral or cartilaginous implants, in particular together with cultivated chondrocytes. 42,43 One of the current leading approaches is in vitro growth of the tissue engineering constructs followed with their implantation into cartilage lesion.…”

Section: Cartilage As a Subject Of Regenerationmentioning

confidence: 99%

Laser-induced regeneration of cartilage

et al. 2011

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Abstract. Laser radiation provides a means to control the fields of temperature and thermo mechanical stress, mass transfer, and modification of fine structure of the cartilage matrix. The aim of this outlook paper is to review physical and biological aspects of laser-induced regeneration of cartilage and to discuss the possibilities and prospects of its clinical applications. The problems and the pathways of tissue regeneration, the types and features of cartilage will be introduced first. Then we will review various actual and prospective approaches for cartilage repair; consider possible mechanisms of laser-induced regeneration. Finally, we present the results in laser regeneration of joints and spine disks cartilages and discuss some future applications of lasers in regenerative medicine. C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Cartilage As a Subject Of Regenerationmentioning

confidence: 99%

Laser-induced regeneration of cartilage

et al. 2011

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“…Experimental studies in rabbits [6,7] and dogs [8] have shown that the repair tissue generated by these processes is fibrocartilaginous in nature, differing from hyaline articular cartilage in biochemical composition, structural organization, durability and biomechanical properties, and degenerates over time [1,7]. The co-expression of types I and II collagens in repair tissue does not occur until one year following subchondral penetration [9].…”

Section: Perforation Of the Subchondral Bonementioning

confidence: 99%

Cell and Tissue Transplant Strategies for Joint Lesions

Fuentes‐Boquete¹,

Gonda²,

Díaz‐Prado³

et al. 2008

TOTRANSJ

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Articular cartilage lesions that do not disrupt the integrity of subchondral bone are not capable of spontaneous repair. The asymptomatic nature of these lesions leads to articular cartilage degeneration and development of the osteoarthritic process. To avoid joint replacement surgery, several cellular therapies have been developed. These therapies focus on the regeneration of a new tissue, whose structure, biochemistry composition and function should be the same as those of endogenous articular cartilage. Current approaches for interrupting the osteoarthritic process produce a fibrocartilaginous tissue, not articular cartilage. The implantation of autologous chondrocytes and autologous mosaicplasty induces a better quality of articular cartilage; however, both techniques damage the existing cartilage because of the need to harvest large numbers of chondrocytes or to extract an osteochondral cylinder for implantation. While stem cells are a promising tool for repairing articular cartilage, their use is in an early experimental stage at this time. Although studies of cell therapy have shown clinical and functional improvement in joints, the ability to regenerate articular cartilage that resists the degeneration process remains elusive.

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“…Die Abrasion stellt allerdings keine suffi ziente Therapieoption bei isolierten Knorpeldefekten, deren Therapie Gegenstand des vorliegenden Artikels sein soll, dar und ist als Palliativeingriff anzusehen [14]. Die mindere Wertigkeit des Verfahrens im Vergleich zur iso lierten Perforation der subchondralen Lamelle ist auch durch experimentelle Daten belegt [15].…”

Section: Abrasionsarthroplastikunclassified