A comparison of 4D flow MRI-derived wall shear stress with computational fluid dynamics methods for intracranial aneurysms and carotid bifurcations — A review

Szajer, Jeremy; Ho‐Shon, Kevin

doi:10.1016/j.mri.2017.12.005

Cited by 70 publications

(51 citation statements)

References 43 publications

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“…Four-dimensional flow MRI, also known as 3D time-resolved phase-contrast MRI, quantifies blood flow in three dimensions and can be used to estimate WSS, SR, and inflow hemodynamics much faster than traditional CFD, although 4D MRI often underestimates WSS. 21,57 Contrast permeability across aneurysm walls as measured by dynamic contrast-enhanced MRI has been found to be predictive of aneurysm rupture risk independent of aneurysm size. 62 Seven-tesla MRI has been used to measure wall thickness, which was found to be inversely related to WSS.…”

Section: Predicting Aneurysm Rupture With Hemodynamics Mrimentioning

confidence: 99%

The biophysical role of hemodynamics in the pathogenesis of cerebral aneurysm formation and rupture

Soldozy¹,

Norat²,

Elsarrag³

et al. 2019

Neurosurgical Focus

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The pathogenesis of intracranial aneurysms remains complex and multifactorial. While vascular, genetic, and epidemiological factors play a role, nascent aneurysm formation is believed to be induced by hemodynamic forces. Hemodynamic stresses and vascular insults lead to additional aneurysm and vessel remodeling. Advanced imaging techniques allow us to better define the roles of aneurysm and vessel morphology and hemodynamic parameters, such as wall shear stress, oscillatory shear index, and patterns of flow on aneurysm formation, growth, and rupture. While a complete understanding of the interplay between these hemodynamic variables remains elusive, the authors review the efforts that have been made over the past several decades in an attempt to elucidate the physical and biological interactions that govern aneurysm pathophysiology. Furthermore, the current clinical utility of hemodynamics in predicting aneurysm rupture is discussed.

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Section: Predicting Aneurysm Rupture With Hemodynamics Mrimentioning

confidence: 99%

The biophysical role of hemodynamics in the pathogenesis of cerebral aneurysm formation and rupture

Soldozy¹,

Norat²,

Elsarrag³

et al. 2019

Neurosurgical Focus

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show abstract

“…In practice, fluid velocity is often used as a proxy observable for wall shear stress [9][10][11]. While obvious in the case of a straight cylindrical channel, the complex shape of the aneurysm and its deformability introduce new aspects whose effects on the connection between flow velocity and wall shear stress needs a thorough investigation.…”

Section: Simulation Setupmentioning

confidence: 99%

“…Flow velocity is one of the principal factors determining the magnitude of WSS. Compared with WSS, in practice, flow velocity is easier to be measured and often acts as a proxy observable for WSS [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effects of size and elasticity on the relation between flow velocity and wall shear stress in side-wall aneurysms: A lattice Boltzmann-based computer simulation study

Wang

Varnik

2019

Preprint

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Blood flow in an artery is a fluid-structure interaction problem. It is widely accepted that aneurysm formation, enlargement and failure are associated with wall shear stress (WSS) which is exerted by flowing blood on the aneurysmal wall. To date, most of the computational studies of this problem assume rigid walls. In particular, in the case of side-wall aneurysms, the combined effect of aneurysm size and wall elasticity on intra-aneurysm (IA) flow characteristics is poorly understood. Here we propose a model of three-dimensional viscous flow in a compliant artery containing an aneurysm by employing the immersed boundarylattice Boltzmann-finite element method. This model allows to adequately account for the elastic deformation of both the blood vessel and aneurysm walls. Using this model, we perform a detailed investigation of the flow through aneurysm under different conditions with a focus on the parameters which may influence the wall shear stress. Most importantly, it is shown in this work that the use of flow velocity as a proxy for wall shear stress is well justified only in those sections of the vessel which are close to the ideal cylindrical geometry. Within the aneurysm domain, however, the correlation between wall shear stress and flow velocity is largely lost due to the complexity of the geometry and the resulting flow pattern. Moreover, the correlations weaken further with the phase shift between flow velocity and transmural pressure. These findings have important implications for medical applications since wall shear stress is believed to play a crucial role in aneurysm rupture.

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“…A three-dimensional gradient-echo sequence with three-directional phase-contrast flow encoding acquisition sequence [4] was used to measure velocities in the model with an isotropic resolution of 0.3 mm, reconstructed to 0.15 mm. The pump (Acandis, Pforzheim, Germany) was placed outside the magnet room, connected via tubing to the model and generated a continuous flow (rate: 1.76 ml 3 /s) through the phantom.…”

Section: Benchmark Problemmentioning

confidence: 99%

“…Water and a contrast agent (Dotarem, Guerbet, Villepinte, France) with a concentration of 1.7 mmol/l were used. A three-dimensional gradient-echo sequence with three-directional phase-contrast flow encoding acquisition sequence [4] was used to measure velocities in the model with an isotropic resolution of 0.3 mm, reconstructed to 0.15 mm. The velocity encoding value (VENC) was set to * e-mail alexander.heinlein@uni-koeln.de * * Corresponding author: e-mail axel.klawonn@uni-koeln.de * * * e-mail jascha.knepper@uni-koeln.de…”

Section: Benchmark Problemmentioning

confidence: 99%

Comparison of MRI measurements and CFD simulations of hemodynamics in intracranial aneurysms using a 3D printed model ‐ A benchmark problem

Giese

Heinlein

Klawonn

et al. 2019

Proc Appl Math and Mech

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A benchmark for the comparison of MRI (Magnetic Resonance Imaging) measurements and CFD (Computational Fluid Dynamics) simulations for blood flow in intracranial aneurysms is presented. The benchmark setting is designed to allow for CFD simulations that are completely independent of the MRI measurements. This facilitates a fair comparison of both methods. Furthermore, results showing the good agreement of MRI and CFD are presented.

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A comparison of 4D flow MRI-derived wall shear stress with computational fluid dynamics methods for intracranial aneurysms and carotid bifurcations — A review

Cited by 70 publications

References 43 publications

The biophysical role of hemodynamics in the pathogenesis of cerebral aneurysm formation and rupture

The biophysical role of hemodynamics in the pathogenesis of cerebral aneurysm formation and rupture

Effects of size and elasticity on the relation between flow velocity and wall shear stress in side-wall aneurysms: A lattice Boltzmann-based computer simulation study

Comparison of MRI measurements and CFD simulations of hemodynamics in intracranial aneurysms using a 3D printed model ‐ A benchmark problem

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