A comparison of 18F-FDG gamma camera PET, mammography and ultrasonography in demonstrating primary disease in locally advanced breast cancer

Marshall, Christopher; Mustafa, Sayed; Wheatley, David C.; Eremin, Jennifer E.; ElSheemy, Mohammed S.; Jibril, Jibril A; Eremin, O.; Griffiths, P.A.

doi:10.1097/01.mnm.0000130239.76326.ca

Cited by 5 publications

(6 citation statements)

References 14 publications

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“…It has shown its potential in assessing the primary lesion, detecting residual disease, monitoring the response to chemotherapy and in staging of the axilla (23,26). The results of this study, using a GCPET scanner, fully support this view.…”

Section: ------------------------------------------------------------supporting

confidence: 72%

“…However, these data were from patient with early disease. In terms of predicting or evaluation of response in LABCs, GCPET is sensitive and more cost-effective than dedicated PET (23).…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

“…All patients were scanned after injection of 140 MBq of 18 F-FDG. Details of the technique used was described in our previous study (23).…”

Section: Patients the Study Was Approved By The Local Ethicsmentioning

confidence: 99%

“…The development of new electronics and software has enabled double-headed gamma cameras, sited in Nuclear Medicine Departments, to be used in a similar mode as a dedicated PET scanncer, although the sensitivity of these systems is not as high as the multiple detector scanners (21,22). Previously, we successfully reported the use of GCPET in the detection of primary breast tumours with a superior sensitivity, compared with mammography and ultrosonography (23). Comparable results were found in a study using GCPET to detect primary lesions in 26 women with a sensitivity of 84.6% (24).…”

Section: Introductionmentioning

confidence: 99%

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18F-FDG dual-headed gamma camera PET in detection of axillary nodal disease in patients with large or locally advanced breast cancer: Possible alternative staging of axilla

Syed

Marshall²,

Griffiths³

et al. 2007

Oncol Rep

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Abstract. Positron emission tomography (PET) has been used in staging the axilla. Gamma Camera PET (GCPET) is a cost effective alternative, but poorly studied. The aim of this study was to assess GCPET in demonstrating metastatic deposits in axillary nodes in patients with a high likelihood of nodal disease. Twenty-seven women with large (T2, T3 or T4) or advanced breast cancer (N1, N2 or M1) were recruited. All patients underwent axillary lymph node removal or biopsy (fine needle aspiration cytology (FNAC) or core cut) and whole body GCPET imaging. Images were reported anonymously and compared with the histological findings. Twenty-one patients proceeded to surgery and 10 had tumour-involved axillary nodes; GCPET was positive in 8 of these. The remaining 6 patients underwent core cut or FNAC of the axillary nodes, 2 of which contained a tumour. GCPET was positive in both cases. Thus, the diagnostic values were: sensitivity 83%, specificity 100%, positive predictive value 100%, negative predictive value 88% and accuracy 93%. In conclusion, GCPET is a reliable method and can be performed in a district general hospital and detecting disease in axillary nodes in certain patients, possibly obviating the need for surgery.

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Section: ------------------------------------------------------------supporting

confidence: 72%

“…However, these data were from patient with early disease. In terms of predicting or evaluation of response in LABCs, GCPET is sensitive and more cost-effective than dedicated PET (23).…”

Section: ------------------------------------------------------------mentioning

confidence: 99%

“…All patients were scanned after injection of 140 MBq of 18 F-FDG. Details of the technique used was described in our previous study (23).…”

Section: Patients the Study Was Approved By The Local Ethicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

18F-FDG dual-headed gamma camera PET in detection of axillary nodal disease in patients with large or locally advanced breast cancer: Possible alternative staging of axilla

Syed

Marshall²,

Griffiths³

et al. 2007

Oncol Rep

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show abstract

“…Other authors [6,9] report false negative results to be significantly more likely when tumours are small (B10 mm) or when their histological grade is moderate-low, and that the sensitivity of the technique is greater with stage III and IV than with stage I and II tumours (83.3% compared to 90.5%). In a comparison of FDG-gamma camera PET with mammography and ultrasonography in 25 patients [10], FDG-gamma camera PET missed only one primary lesion which was found to be 8 mm size in operative histopathological evaluation and which was also missed with mammography and ultrasonography. Several studies compared the results of FDG-PET with conventional techniques such as mammography, physical examination or ultrasonography.…”

Section: Diagnostic Of Primary Tumoursmentioning

confidence: 95%