A Comparison in Intestine and Leg of the Reflex Vascular Response to Carotid-Aortic Chemoreceptor Stimulation

Bernthal, Theodore; Schwind, F

doi:10.1152/ajplegacy.1945.143.3.361

Cited by 35 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a similar phenomenon has been described in the hind limb (Bernthal & Schwind, 1945) and in a muscular vascular bed (Costin & Skinner, 1970) of dogs immediately following the vasoconstriction induced by hypoxic or chemical stimulation of chemoreceptors. PVCD has also been observed in muscular vascular beds of atropinized, baroreceptor deafferented cats after electrical chemoreceptor stimulation (Killip, 1963) and after electrical stimulation of the diencephalon (Feigl, 1964).…”

Section: Introductionsupporting

confidence: 64%

Passive vasodilatation of the hind limb after sympathetic preganglionic stimulation

Lioy¹,

Polosa²

1971

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The post-vasoconstriction dilatation (PVCD) observed after release of carotid clamping has been attributed to baroreceptor stimulation. However, PVCD has been observed in baroreceptor deafferented animals following cessation of stimulation of the diencephalon or of chemoreceptor fibres.2. The effects of preganglionic (ventral roots) and post-ganglionic (sciatic nerve) stimulation upon the vascular resistance of the hind limb of anaesthetized cats and dogs was investigated. The limb was vascularly isolated and perfused at constant flow with the animal's own arterial blood. The animals were atropinized and neuromuscular block was obtained with gallamine triethiodide.3. PVCD was observed upon cessation of stimulation of intact preganglionic fibres or of their peripheral stump.4. PVCD was dependent upon the existence of neurogenic vasomotor tone in the vessels, but independent from baroreceptor influences.5. PVCD was never observed after cessation of stimulation of the postganglionic fibres.6. Similar results were obtained after removal of the skin of the perfused limb.7. The possibility that the post-vasoconstriction dilatation observed in these experiments is due to the existence of a preganglionic inhibitory system is discussed.

show abstract

Section: Introductionsupporting

confidence: 64%

Passive vasodilatation of the hind limb after sympathetic preganglionic stimulation

Lioy¹,

Polosa²

1971

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…Post-hypoxic dilatation. The sudden, brief decline in vascular resistance after cessation of hypoxia, "post-hypoxic dilatation," has been observed previously by a number of investigators (29)(30)(31), but the mechanism responsible for it has been disputed. Litwin, Dil and Aviado believe that this phenomenon is neurogenic in origin, but not dependent upon an intact chemoreceptor reflex arc (31).…”

Section: Methodsmentioning

confidence: 88%

The Effects of Acute Hypoxia on the Systemic Venous and Arterial Systems and on Myocardial Contractile Force

Kahler¹,

Goldblatt²,

Braunwald³

1962

J. Clin. Invest.

View full text Add to dashboard Cite

“…No search was made for evidence of reflex vasodilatation. There is also the possibility that on release of the umbilical cord and restoration of blood gas tensions, there is total withdrawal of afferent chemoreceptor discharge as proposed by Bernthal & Schwind (1945) in the adult dog. Yet in the foetal lamb this phenomenon persists after vagotomy, and so is more likely due to the local effect of partial ischaemia.…”

Section: Foetal Circulationmentioning

confidence: 99%

Vasomotor responses in the hind limbs of foetal and new‐born lambs to asphyxia and aortic chemoreceptor stimulation

Dawes¹,

Lewis²,

Milligan³

et al. 1968

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Hind limb blood flow was measured in lambs of from 91 days gestation (delivered by Caesarean section) to 1 month after birth (term is about 147 days), under chloralose anaesthesia. Vascular resistance/100 g wet wt. increased progressively with age. There was reflex femoral vascular tone from the earliest age studied, as shown by vasodilatation on cutting the sciatic nerve.2. On asphyxia by cord occlusion reflex femoral vasoconstriction began earlier and was somewhat greater in older foetal lambs. At all ages, and after denervation of the hind limb, there was vasodilatation after local ischaemia, and a vasoconstriction of delayed onset during asphyxia attributed to release of noradrenaline into the circulation. The vasoconstrictor effect of noradrenaline in immature lambs was at least as great as at term or in the new-born.3. Injections of minimal effective doses of cyanide were used to localize possible chemoreceptor sites in foetal lambs. Injection into the left atrium caused a rise of arterial pressure, femoral vasoconstriction and a complex change in heart rate (usually bradycardia) but rarely any respiratory movement. After atropine, cyanide caused a large tachycardia. All responses were much reduced or abolished by cervical vagotomy.4. Injection of the same doses of cyanide into a jugular vein, the right ventricle, pulmonary or common carotid arteries of foetal lambs caused

show abstract

A Comparison in Intestine and Leg of the Reflex Vascular Response to Carotid-Aortic Chemoreceptor Stimulation

Cited by 35 publications

References 0 publications

Passive vasodilatation of the hind limb after sympathetic preganglionic stimulation

Passive vasodilatation of the hind limb after sympathetic preganglionic stimulation

The Effects of Acute Hypoxia on the Systemic Venous and Arterial Systems and on Myocardial Contractile Force

Vasomotor responses in the hind limbs of foetal and new‐born lambs to asphyxia and aortic chemoreceptor stimulation

Contact Info

Product

Resources

About