A comparison between two different definitions of contrast-induced acute kidney injury in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention

Contrast-induced acute kidney injury and mortality in ST elevation myocardial infarction treated with primary percutaneous coronary intervention

“…In addition, rates of CI-AKI defined according to RIFLE (CKD-EPI) and AKIN were consistent with previous studies on STEMI5 ranging from 7.4% in haemodynamically stable STEMI patients to 18.3% using more liberal ones and including haemodynamic unstable patients. Stringent CK-AKI definition has the advantages of identifying a low event rate with high clinical relevance, while the use of more liberal definitions has the potential to increase the rate of events but with less prognosis relevance.…”

Impact of acute kidney injury in elderly (≥80 years) patients undergoing percutaneous coronary intervention

“…Although the incidence of AKI depends on the population studied and the definition applied, rates of AKI observed in this elderly patient cohort are higher than the ones reported in unrestricted patients undergoing PCI given their high baseline risk . Consistent with previous data, the incidence of AKI was relatively high also in patients with normal baseline renal function.…”

Fragmented QRS complex predicts contrast‐induced nephropathy and in‐hospital mortality after primary percutaneous coronary intervention in patients with ST‐segment elevation myocardial infarction

“…Patients with acute STEMI are more prone to this complication. CIN is significantly associated with poor clinical outcomes, including mortality, after primary PCI for STEMI . Although the exact mechanism of CIN is still not completely understood, there is increasing evidence to support the critical role of inflammatory response in the pathogenesis of CIN .…”

“…CIN is significantly associated with poor clinical outcomes, including mortality, after primary PCI for STEMI. 23,24 Although the exact mechanism of CIN is still not completely understood, there is increasing evidence to support the critical role of inflammatory response in the pathogenesis of CIN. 6 Patti et al 7 demonstrated that short-term pretreatment with high-dose atorvastatin load prevents CIN and shortens hospital stay in patients with acute coronary syndrome undergoing PCI, and they suggested that anti-inflammatory effects may be involved in this renal protection.…”