A Comparison between Transcutaneous and Total Serum Bilirubin in Healthy-term Greek Neonates with Clinical Jaundice

Neocleous, Charalambos; Adramerina, Alkistis; Limnaios, Stefanos; Symeonidis, Symeon; Spanou, Chrysoula; Malakozi, Marina; Mpampalis, Evangelos

doi:10.14712/23362936.2014.4

Cited by 8 publications

(8 citation statements)

References 14 publications

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“…However a study in Greek neonates did not find a good correlation between TcB and TSB in otherwise healthy term neonates. [8] Though in agreement, but the correlation coefficient "r" between TcB and TSB measurements in our study was 0.95 which is at the higher side of previously published comparisons.…”

Section: Satapathy and Mohanty; Comparison Of Transcutaneous And Total supporting

confidence: 72%

Comparison of Transcutaneous and Total Serum Bilirubin in Newborns of 34 or More Weeks of Gestation

Satapathy

Resident

Mohanty

2018

AJCPN

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Background: Measuring the bilirubin concentration with accuracy is essential for diagnosis and proper management of neonatal hyperbilirubinemia. Serum bilirubin (TSB) is considered as the gold standard, but it takes some time.It is painful for the baby and expensive and stressful for the parents. Transcutaneous bilirubin (TcB) can be measured without pain and is very fast. Aim of the study: To assess if TcB measurement can be an effective alternate screening test for diagnosing neonatal hyperbilirubinemia. Subjects and Methods: A total of 97 newborns with clinical jaundice were enrolled. Before the initiation of phototherapy, venous blood for TSB measurement was drawn. Within 30 minutes Drager's bilirubinometer JM-103 measured TcB on the infants' sternum. Simple linear regression analysis determined the relation between TcB and TSB values. The strength of the relationship and agreement between these two methods was calculated by Pearson's correlation coefficient "r" and Bland-Altmann plot respectively. Results: The TcB correlated well with TSB(r=0.95, 95% confidence interval= 0.93 to 0.97). The mean deviation and variability (±2SD) of TcB from TSB were 0.8 and ±2.5mg/dl respectively. There was a good agreement between TcB and TSB. Conclusion: Our study showed that TcB checking can be applied as a valuable screening tool in neonates with clinically suspected jaundice.

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Section: Satapathy and Mohanty; Comparison Of Transcutaneous And Total supporting

confidence: 72%

Comparison of Transcutaneous and Total Serum Bilirubin in Newborns of 34 or More Weeks of Gestation

Satapathy

Resident

Mohanty

2018

AJCPN

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“…Some studies mentioned that BiliChek has a tendency to overestimate serum bilirubin; whereas others mentioned that the TcB level measured using BiliChek was on average lower than the TSB level . In our studies, we found that the mean TcB level is mostly higher than the mean TSB level in term and late‐preterm infants before, under, and 24 hours after phototherapy; however, the TcB level was lower than the TSB level when measurement was obtained during phototherapy of 5 days in term infants and 6 days in late‐preterm infants.…”

Section: Discussioncontrasting

confidence: 45%

Comparison of transcutaneous and serum bilirubin before, under, and after phototherapy in term and late‐preterm infants

Yang

Liu

Chen

2019

The Kaohsiung J of Med Scie

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This study aimed to determine the correlation of transcutaneous bilirubin (TcB) with total serum bilirubin (TSB) in infants receiving phototherapy and the accuracy of TcB for deciding the time to discontinue phototherapy. Paired TcB and TSB levels were assessed in 52 term and 56 late-preterm infants receiving phototherapy. TcB was measured in the unexposed skin of the middle forehead using a noninvasive bilirubin analyzer, BiliChek. TSB was measured every morning, and TcB was measured 2 hours after TSB measurements. Bland-Altman plots, linear regression, multivariate pair wise correlation, and receiver operating characteristic curve (ROC) analyses were performed. Bland-Altman plots before, under, and 24 hours after phototherapy in term and late-preterm infants revealed that TcB and TSB have higher consistency. TcB and TSB showed positive linear correlation before, under, and after phototherapy in both infant groups. In the multivariate pair wise correlations, differences between TcB and TSB were negatively correlated with phototherapy duration in term (correlation coefficient = −0.233, P value = .001) and late-preterm (correlation coefficient = −0.198, P value = .002) infants. Cutoff levels of TcB for discontinuing phototherapy based on the ROC analysis were 13.8 (sensitivity of 90%, specificity of 84%, area under the curve [AUC] 0.94) and 11.8 mg/dL (sensitivity of 84%, specificity of 88%, AUC 0.92) in term and late-preterm infants, respectively. TcB and TSB before, under, and after phototherapy in both term and late-preterm infants showed good correlation and higher consistency with jaundice. To reduce repetitive blood sampling for TSB, TcB measurement may be a reliable method for term and latepreterm infants undergoing phototherapy.

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“…This is in agreement with other studies conducted in the North American, Hispanic, Chinese, and Italian populations. 7 - 9 , 12 - 14 However, a study from Greece 4 concluded that TcB does not correlate well with TSB and tends to underestimate TSB.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the studies had validated TcB in relatively homogenous populations, such as Greek, Caucasian, Chinese, Hispanic, and Africans. 4 - 7 Studies were varied in their assessment of the accuracy of TcB measurement; poor to excellent agreement between TSB and TcB has been reported. 4 - 9 The aim of this prospective cohort study was to investigate the accuracy of TcB as measured by BiliCheck device (SpectRx, Inc., Norcross, GA, USA) in jaundiced, otherwise healthy, Saudi term infants who required TSB measurements.…”

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confidence: 99%

Transcutaneous bilirubin measurement in healthy Saudi term newborns

Al-Saedi

2016

SMJ

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Objectives:To evaluate the accuracy of transcutaneous bilirubin (TcB) measurement in healthy, jaundiced Saudi term newborns.Methods:This prospective, cohort study was carried out from January 2009 to December 2012 on jaundiced, term infants admitted at the King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia. Paired TcB and total serum bilirubin (TSB) from healthy jaundiced term newborns were obtained. The correlation and the mean difference between the 2 methods were calculated, and Bhutani nomogram for prediction of TSB by TcB was used. Any bilirubin level at low and above the intermediate risk zone was considered significant.Results:We obtained 665 paired TcB and TSB measurements from 665 newborns. The mean age at bilirubin measurement was 44.2 ± 21 hour. Mean TSB was 147 ± 45 µmol/L, and TcB was 156 ± 50 µmol/L. Linear regression analysis showed a significant correlation between TcB and TSB (r: 0.84; 95% confidence interval [CI] = 0.82-0.86; p<0.001). The TcB tends to overestimate TSB. The mean difference between paired TcB and TSB was 17 µmol /L with a 95% CI of 40 ± 77 µmol/L. The TcB was sensitive, but less specific. The TcB sensitivity was 83% and specificity was 71% to predict TSB during the first 72 hours of life for the whole study group. The positive predictive value was 63%, and negative predictive value was 87%.Conclusion:As found in this study, among the jaundiced healthy term Saudi newborns, TcB measurement provided accurate estimates of TSB values. The TcB measurements can be used effectively to screen newborns for significant jaundice.

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A Comparison between Transcutaneous and Total Serum Bilirubin in Healthy-term Greek Neonates with Clinical Jaundice

Cited by 8 publications

References 14 publications

Comparison of Transcutaneous and Total Serum Bilirubin in Newborns of 34 or More Weeks of Gestation

Comparison of Transcutaneous and Total Serum Bilirubin in Newborns of 34 or More Weeks of Gestation

Comparison of transcutaneous and serum bilirubin before, under, and after phototherapy in term and late‐preterm infants

Transcutaneous bilirubin measurement in healthy Saudi term newborns

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