A Comparison Between the Uptakes of Radioactive Perchlorate and Iodide by Rat and Guinea-Pig Thyroid Glands

Chow, S. Y.; Chang, L. R.; Yen, M. S.

doi:10.1677/joe.0.0450001

Cited by 24 publications

(27 citation statements)

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“…2, a mean cell count of 5.0 ϫ 10 5 /well and a mean thyroid cell volume of 3.73 pl (8), the calculated cell/medium ratio was 62 at the TSH-induced maximum uptake of perchlorate. Our results are consistent with studies of perchlorate uptake using 36 ClO 4 Ϫ in rats and guinea pigs showing that the isotope was concentrated in the thyroid tissue and that the concentration was TSH dependent (9,21).…”

Section: Discussionsupporting

confidence: 91%

“…This is in contradiction to previous studies showing that radiolabeled perchlorate was concentrated in thyroid tissue in vivo (9,10,32) and contrasts with the selectivity series based on physiological anion transport in thyroid tissue: , 34, 35). Recently, Dohan et al (14) published additional evidence of NIS-mediated active transport of perchlorate both in vivo and in vitro.…”

contrasting

confidence: 99%

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Thyroid-stimulating hormone increases active transport of perchlorate into thyroid cells

Tran

Valentín-Blasini²,

Blount³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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Section: Discussionsupporting

confidence: 91%

contrasting

confidence: 99%

Thyroid-stimulating hormone increases active transport of perchlorate into thyroid cells

Tran

Valentín-Blasini²,

Blount³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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“…Several kinetic studies of these compounds have been reported in the literature. However, the majority of these are reported as a ratio of tissue (e.g., thyroid) versus plasma concentration of radiolabeled iodide and/or perchlorate (Chow et al, 1969;Chow and Woodbury, 1970;Wollman and Reed, 1959).…”

Section: Discussionmentioning

confidence: 99%

“…Perchlorate is actively taken up by the thyroid gland and prevents iodide uptake into the thyroid, disrupting thyroid hormone synthesis and secretion (Anbar et al, 1959;Capen 1996;Chow et al, 1969;Wolff, 1998). Since perchlorate competitively inhibits iodide uptake into the thyroid, less iodide is available for organification.…”

Section: Discussionmentioning

confidence: 99%

Effects of Perchlorate on Thyroidal Uptake of Iodide with Corresponding Hormonal Changes

Yun¹,

Todd²,

Young³

et al. 2000

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Approved for public release; distribution is unlimited. ABSTRACT (Maximum 200 words)Perchlorate interferes with iodide accumulation in the thyroid resulting in reduced thyroidal hormone synthesis. The objective of this project was to conduct a series of experiments to investigate the role of perchlorate on the uptake of iodide in the thyroid and its effects on the synthesis of thyroid hormones. A time course study with perchlorate (single iv dose) was performed to investigate its kinetic behavior in the adult male rat. Rats were injected with 0, 0.01, 0.1 1 and 3 mg perchlorate/kg via tail vein, challenged with 1251 with carrier at 2 h post dosing, and euthanized at predetermined time points. Three groups (n=6 per group) of 1-, 5-, and 14-day drinking water studies were performed at different levels of perchlorate (0, 1, 3 and 10 mg/kg). At the end of exposure, rats were challenged once by tail vein injection with 1251 with carrier. Dose-related inhibition of thyroid iodide uptake after a single iv dose of perchlorate, and both dose-and timedependent changes in inhibition of thyroid iodide uptake were observed in drinking water studies. In both the single dose and drinking water studies, TSH and free T4 levels were elevated with T4 levels decreased. Serum T3 levels in drinking water studies remained unchanged in all dosing groups.

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“…At normal goitrogenic levels of these compounds, there is little uptake of the goitrogen into the thyroid (Chow et al 1969) therefore their activity must be upon the external membranes of the gland.…”

Section: Antithyroid Compoundsmentioning

confidence: 99%

Congenital goitre in sheep in southern Tasmania

Statham¹,

Bray²

1975

Aust. J. Agric. Res.

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Congenital goitre was first recorded in Tasmanian sheep In 1945. Severe but sporadic outbreaks have since occurred in 1956, 1964 and 1968. The disease seemed to be associated with particular farms and its incidence often differed markedly between ewe flocks on the one farm. A survey indicated that the condition was mainly confined to the Derwent Valley and the northern Midlands. Studies involved a grazing trial near Bothwell, where goitre was endemic, and included supporting animal house tnals and plant growth studies. Soil type was shown to be a major factor in the disease: ewes grazing pasture on a sandy soil produced many more goitrous lambs than ewes grazing pasture on clay soil. Analyses of the two pastures revealed that those on sandy so11 contained less iodine than those on clay soil but neither contained the minimum level necessary to prevent goitre. Observations revealed that outbreaks of the disease followed wet autumns with subsequent lush pasture during pregnancy. This correlation could be explained if pasture grown under moist conditions contained less iodine than pasture grown under moisture stress. However, experiments with the two main pasture species (perennial ryegrass and subterranean clover) showed that plant iodine levels were not affected by the water supply. Two goitrogenic agents, nitrate and thiocyanate, were present in the pastures, but they were not considered to be Important in the aetiology of the disease. Similarly, the drinking water was found to be unimportant, even though the two sources available contained widely different amounts of iodine. Apparently, between-year variation in the incidence of goitre and the effect of soil type can best be explained by a varying iodine intake dependent on soil ingestion which varies with pasture availability. This hypothesis is discussed in the light of the results.

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A Comparison Between the Uptakes of Radioactive Perchlorate and Iodide by Rat and Guinea-Pig Thyroid Glands

Cited by 24 publications

References 0 publications

Thyroid-stimulating hormone increases active transport of perchlorate into thyroid cells

Thyroid-stimulating hormone increases active transport of perchlorate into thyroid cells

Effects of Perchlorate on Thyroidal Uptake of Iodide with Corresponding Hormonal Changes

Congenital goitre in sheep in southern Tasmania

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