A Comparison Between the Treatments of Functional and Nonfunctional Carotid Body Tumors

Zeng, Guojun; Zhao, Jichun; Ma, Yukui; Huang, Bin; Yang, Yi; Feng, Hui-Fang

doi:10.1016/j.avsg.2011.11.012

Cited by 19 publications

(20 citation statements)

References 30 publications

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“…4 If screening does diagnose a functional CBT in the absence of synchronous paraganglioma, then the patient should receive a-blockade, followed by b-blockade for symptom control before CBT excision. 6 Most reported CBTs are asymptomatic, which is consistent with our cohort. A neck mass is the presenting symptom in w60% of patients.…”

Section: Discussionsupporting

confidence: 91%

Current surgical management of carotid body tumors

Davila

Chang

Stone

et al. 2016

Journal of Vascular Surgery

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CBT can be treated with minimal morbidity and mortality; however, the subgroup of patients with positive SDH mutations may represent a variant group of younger patients. Vascular surgeons should be aware of genetic testing to identify patients and family members who should undergo additional preoperative testing and monitoring for other paragangliomas. Concomitant lymph node dissection does not appear to add value in absence of clinic suspicion for malignancy.

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Section: Discussionsupporting

confidence: 91%

Current surgical management of carotid body tumors

Davila

Chang

Stone

et al. 2016

Journal of Vascular Surgery

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“…Meticulous preoperative evaluation, involving the measurement of catecholamines and alpha‐ and beta‐adrenergic blockade, and soft intraoperative manipulation of the tissues are essential to avoid life‐threatening complications 40 . Dividing a series of 46 CPGs into two groups, of 5 functional and 41 non‐functional patients, made it possible to show that surgery is safe and effective in both groups 41 …”

Section: Discussionmentioning

confidence: 99%

“…40 Dividing a series of 46 CPGs into two groups, of 5 functional and 41 non-functional patients, made it possible to show that surgery is safe and effective in both groups. 41 As well as the secretion of catecholamines, five cases have been described in the literature that exclusively secreted dopamine, all of which were associated with bilateral CPGs and/or malignancy. 42 Our experience is limited to a single PG case in the organ of Zuckerkandl, which was satisfactorily controlled/treated with the aforementioned preoperative and intraoperative measures.…”

Section: Resection Of a Functional Cpgmentioning

confidence: 99%

Simple and complex carotid paragangliomas. Three decades of experience and literature review

et al. 2020

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Background: Carotid paragangliomas are rare tumors. They are usually unique, non-secreting, resectable, and benign. However, additional rare cases of complex tumors (bilateral, secretory, nonresectable, or malignant) complicate the management and final outcomes. Methods: Records of paragangliomas from our hospital are reviewed. Criteria defining complex paragangliomas have been previously defined. These are compared with those of the simple group. Results: Fifty patients, two groups: simple (n = 39) and complex (n = 11). The patients in the complex group were significantly younger (47.7 vs 63.8 years). Postoperative nerve complications (45.4% vs 6.3%) and mortality during follow-up (27.3% vs 0%) were significantly more common in the complex group. Vascular complications (0% vs 3.1%) and early mortality (0%) were similarly in both groups. Conclusions: Patients with complex carotid paragangliomas are heterogeneous. The former are younger, exhibit a high degree of diagnostic and therapeutic complexity, and have poorer morbidity and mortality. Surgical experience and interdisciplinary collaboration are essential.

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“…When a malignancy is suspected, tumor resection should be accompanied by lymphadenectomy and eventual radiotherapy which seems to be effective for isolated metastasis [ 20 ], although no malignancy was diagnosed in our series. Finally, when the tumor is considered functional, careful evaluation before surgery, measurement of serum catecholamine, treatment with adrenergic blockers, and gentle manipulations during the excision are essential for optimal results [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, their incidence is low, reaching only 1 : 30000 [ 2 ]. Although these tumors are mostly benign, 5–30% of cases present with a clinical malignant behaviour or increased functionality [ 3 , 4 ]. Furthermore, due to a potentially infiltrating and disseminating growth, CBTs should be regarded as semimalignant.…”

Section: Introductionmentioning

confidence: 99%

Multidisciplinary Management of Carotid Body Tumors in a Tertiary Urban Institution

Galyfos

Stamatatos

Kerasidis

et al. 2015

International Journal of Vascular Medicine

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Objective. Aim of this study is to present the experience of our institution in carotid body tumors (CBTs) treatment. Methods. All cases treated in a Vascular Surgery Department within 2.5 years (03/2013–09/2015) were retrospectively evaluated. Demographics, diagnostic, and treatment strategy were recorded. All patients with known CBT underwent ultrasound and magnetic resonance imaging preoperatively. All cases were classified according to the Shamblin type and evaluated by a radiologist, otolaryngologist, and anesthesiologist before and after surgery. Major outcomes included mortality, stroke, cranial nerve injury, and recurrence. Results. Overall, nine patients (mean age: 59.5 ± 16.3 years) with a total of ten CBTs were treated. There was no gender prevalence and most of the cases (55%) were asymptomatic. There were no functional or familial cases. There was only one bilateral case treated in a staged manner. No preoperative embolization of CBTs was performed. Mortality and stroke rates were null. No severe complication was observed in the early and late setting. No malignancy was recorded. Mean follow-up was 15.6 ± 7.8 months. Conclusions. Multidisciplinary management of patients with CBTs is imperative for optimal results, especially in type III tumors, bilateral or functional cases. After careful treatment planning and intraoperative manipulations, complications could be avoided even without preoperative embolization.

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A Comparison Between the Treatments of Functional and Nonfunctional Carotid Body Tumors

Cited by 19 publications

References 30 publications

Current surgical management of carotid body tumors

Current surgical management of carotid body tumors

Simple and complex carotid paragangliomas. Three decades of experience and literature review

Multidisciplinary Management of Carotid Body Tumors in a Tertiary Urban Institution

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