A comparison between the amblyopic eye and normal fellow eye ocular architecture in children with hyperopic anisometropic amblyopia

Wang, Bob Z.; Taranath, Deepa

doi:10.1016/j.jaapos.2012.06.006

Cited by 24 publications

(21 citation statements)

References 17 publications

(17 reference statements)

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“…Third, we compared the amblyopic eye with the fellow eye in the same patient with unilateral amblyopia; however, there was no normal group for comparison. Wang et al44 stated that the fellow eye may not be normal on OCT in patients with anisometropic amblyopia. Furthermore, most of the differences in retinal thickness were less than 5 μm which is equivalent to the spatial resolution of the instrument.…”

Section: Discussionmentioning

confidence: 99%

A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography

Araki¹,

Miki²,

Yamashita³

et al. 2014

OPTH

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PurposeTo compare the macular retinal thickness and characteristics of optic nerve head (ONH) parameters in amblyopic and fellow eyes in patients with unilateral amblyopia.Patients and methodsA total of 21 patients with unilateral amblyopia (14 patients with anisometropic amblyopia, four patients with strabismic amblyopia, and three patients with both) were examined using spectral-domain optical coherence tomography. The mean age of the patients was 8.5±3.5 years. The examined parameters included the mean macular (full, inner, and outer), ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL) thicknesses, and ONH parameters (rim volume, nerve head volume, cup volume, rim area, optic disc area, cup area, and cup-to-disc area ratio).ResultsThe amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001). Among the macular retinal thickness parameters, the cpRNFL thickness (P<0.01), macular full retinal thickness (3 mm region) (P<0.01), and macular outer retinal thickness (1 and 3 mm regions) (P<0.05) were significantly thicker in the amblyopic eyes than in the fellow eyes, while the ganglion cell complex thickness, macular full retinal thickness (1 mm region), and macular inner retinal thickness (1 and 3 mm regions) were not significantly different. Among the ONH parameters, the rim area was significantly larger and the cup-to-disc area ratio was smaller in the amblyopic eyes than in the fellow eyes (P<0.05). None of the other ONH parameters were significantly different between the investigated eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm region were significantly correlated with the difference in axial length (P<0.05, r=−0.48; P<0.01, r=−0.59, respectively) and refractive error (P<0.05, r=0.50; P<0.01, r=0.60, respectively). The other parameters were not significantly related to the difference in axial length, refractive error, or best corrected visual acuity.ConclusionWe found significant differences in some of the morphological measurements between amblyopic and fellow eyes that appear to be independent of abnormalities in the visual cortex.

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Section: Discussionmentioning

confidence: 99%

A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography

Araki¹,

Miki²,

Yamashita³

et al. 2014

OPTH

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“…Cass and Tromans compared anisometropic and strabismic amblyopes to paediatric and adult controls and found no significant differences in corneal curvature between the fellow eyes, or between the different cohorts. Similarly, Wang and Taranath used Scheimpflug imaging to examine hyperopic anisometropes with amblyopia and found no significant differences in mean anterior or posterior corneal curvature between the fellow eyes (~0.12 D steeper in the amblyopic eye). Conversely, Debert et al .…”

Section: Visual and Functional Impact Of Astigmatismmentioning

confidence: 99%

The visual and functional impacts of astigmatism and its clinical management

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Vincent

Collins

2014

Ophthalmic Physiologic Optic

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Purpose: To provide a comprehensive overview of research examining the impact of astigmatism on clinical and functional measures of vision, the short and longer term adaptations to astigmatism that occur in the visual system, and the currently available clinical options for the management of patients with astigmatism. Recent findings: The presence of astigmatism can lead to substantial reductions in visual performance in a variety of clinical vision measures and functional visual tasks. Recent evidence demonstrates that astigmatic blur results in short-term adaptations in the visual system that appear to reduce the perceived impact of astigmatism on vision. In the longer term, uncorrected astigmatism in childhood can also significantly impact on visual development, resulting in amblyopia. Astigmatism is also associated with the development of spherical refractive errors. Although the clinical correction of small magnitudes of astigmatism is relatively straightforward, the precise, reliable correction of astigmatism (particularly high astigmatism) can be challenging. A wide variety of refractive corrections are now available for the patient with astigmatism, including spectacle, contact lens and surgical options. Conclusion: Astigmatism is one of the most common refractive errors managed in clinical ophthalmic practice. The significant visual and functional impacts of astigmatism emphasise the importance of its reliable clinical management. With continued improvements in ocular measurement techniques and developments in a range of different refractive correction technologies, the future promises the potential for more precise and comprehensive correction options for astigmatic patients.

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“…Eye growth during childhood is a visually guided process, and degradation or alteration of visual input may disrupt growth [18]. Numerous studies have evaluated the effects of early abnormal visual experience in relation to macular thickness in children with strabismic and anisometropic amblyopia [19][20][21][22][23][24]. Despite the obvious ocular problems, in light of the unique challenges of retinal imaging in children, there are few reports on retinal structure in children with Down syndrome.…”

Section: Introductionmentioning

confidence: 99%