A comparison between standard and high density Resilient AneuRx in reducing aneurysm sac pressure in a chronic canine model

Abstract

Despite absence of an endoleak, intra-sac pressure remained high in the STA group. RSA effectively reduced sac pressure over time. Graft porosity appears to be an important factor that may determine the outcome of EVAR. These findings may be useful in designing improved endograft.

A reproducible swine model of a surgically created saccular thoracic aortic aneurysm

“…Verification of new treatment devices from an engineering perspective can be performed using an in vitro simulator [11]. However, in vivo verification using disease model animals is indispensable for the clinical application of new therapeutic devices and for mid-to long-term safety assessment [12]. Furthermore, with regard to aortic diseases, the verification of the repair mechanisms of stem cells in the pathological aortic wall [13] and the possibility of regeneration with intravenous administration of mesenchymal stem cells in a rat abdominal aortic aneurysm model [14] have been reported in recent years.…”

Endovascular Treatment of Endoleaks Following EVAR

“…Type IV endoleaks are not true leaks but represent passage of blood through the graft fabric as a result of porosity. Typically this type of endoleak is transient and only noted at the time of repair appearing as a blush on the post-deployment angiogram, when patients are often fully anticoagulated, and resolve spontaneously after the withdrawal of anticoagulation [29]. This type of endoleak has been eliminated by changes in graft porosity.…”