A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid–polymer hybrid nanoparticles

Wang, Yajie; Kho, Katherine; Cheow, Wean Sin; Hadinoto, Kunn

doi:10.1016/j.ijpharm.2011.12.045

Cited by 140 publications

(68 citation statements)

References 21 publications

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“…Comparing these values with previous reports, we [34] achieved higher productivity biomass and IPS for G. lucidum and G. frondosa in fewer days (three days) [26,30,31]. The biomass of A. blazei was similar to previous reports, but its IPS value was higher [15,32] (Table 4).…”

Section: Discussionsupporting

confidence: 86%

Isolation and Characterization of Novel Antimicrobial Peptides from Selected Plant Species

Ahmad¹,

Shan²,

Awang³

et al. 2013

TOPROCJ

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Ganoderma lucidum, Grifola frondosa and Agaricus blazei mushrooms were cultured in a 14 L bioreactor using low-cost, non-conventional culture media. To produce useful raw material for the development of functional products, the biomass produced in the bioreactors was subjected to the following drying processes: convection, infrared radiation, spray drying and freeze-drying. The highest antioxidant activity (ORAC values) and HMGCoA reductase inhibitory capacity were obtained with G. lucidum, (ORAC value of 10,594±128.1 and HMGCoA reductase inhibitory capacity of 78.22±0.01), followed by G. frondosa (ORAC value of 6,919±231.6 and HMGCoA reductase inhibitory capacity of 71.45±1.48) when the biomass was processed via freeze-drying.

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Section: Discussionsupporting

confidence: 86%

Isolation and Characterization of Novel Antimicrobial Peptides from Selected Plant Species

Ahmad¹,

Shan²,

Awang³

et al. 2013

TOPROCJ

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“…This issue has been resolved by transforming nanoparticles into inhalable microaggregates via numerous techniques like spray drying and spray freeze drying or with leucine, mannitol, and PVA as matrix components [89, 90]. Spray freeze dried microaggregates exhibited superior aerosolization performance compared to those produced by spray drying and this was credited to the porous structure and low density of the particles [91–93]. Various investigations on nanoparticulate formulations of inhaled drugs are listed in Table 2.…”

Section: Novel Drug Delivery System For Dpimentioning

confidence: 99%

Dry Powder Inhalers: A Focus on Advancements in Novel Drug Delivery Systems

Mehta

2016

Journal of Drug Delivery

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Administration of drug molecules by inhalation route for treatment of respiratory diseases has the ability to deliver drugs, hormones, nucleic acids, steroids, proteins, and peptides, particularly to the site of action, improving the efficacy of the treatment and consequently lessening adverse effects of the treatment. Numerous inhalation delivery systems have been developed and studied to treat respiratory diseases such as asthma, COPD, and other pulmonary infections. The progress of disciplines such as biomaterials science, nanotechnology, particle engineering, molecular biology, and cell biology permits further improvement of the treatment capability. The present review analyzes modern therapeutic approaches of inhaled drugs with special emphasis on novel drug delivery system for treatment of various respiratory diseases.

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“…Th e resultant nanoemulsion was poured into 12 mL of deionized water and sonicated again for 1 min at room temperature. Afterwards, the nanoemulsion was stirred overnight at room temperature to evaporate the organic phase, and the resultant nanoparticle suspension was centrifuged twice at 11,000 rpm to remove the non-encapsulated drug and excess lipid (Wang et al 2012). …”

Section: Preparation Of Lpns By Double-emulsifi Cation Solvent Evapormentioning

confidence: 99%

“…Pulmonary administration leads to better therapeutic eff ect at a lower fraction of dose. For example, an inhaled dose of 100 -200 μ g of salbutamol is therapeutically equivalent to an oral administration of 2 -4 mg (Labiris andDolovich 2003, Chono et al 2008;Wang et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Pulmonary delivery of antitubercular drugs using spray-dried lipid–polymer hybrid nanoparticles

Bhardwaj

Mehta

Yadav³

et al. 2015

Artificial Cells, Nanomedicine, and Biotechnology

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The present study aimed to develop lipid-polymer hybrid nanoparticles (LPNs) for the combined pulmonary delivery of isoniazid (INH) and ciprofloxacin hydrochloride (CIP HCl). Drug-loaded LPNs were prepared by the double-emulsification solvent evaporation method using the three-factor three-level Box-Behnken design. The optimized formulation had a size of 111.81 ± 1.2 nm, PDI of 0.189 ± 1.4, and PDE of 63.64 ± 2.12% for INH-loaded LPN, and a size of 172.23 ± 2.31 nm, PDI of 0.169 ± 1.23, and PDE of 68.49 ± 2.54% for CIP HCl-loaded LPN. Drug release was found to be sustained and controlled at lower pH and followed the Peppas model. The in vitro uptake study in alveolar macrophage (AM) showed that uptake of the drugs was increased significantly if administered in the form of LPN. The stability study proved the applications of adding PLGA in LPN as the polymeric core, which leads to a much more stable product as compared to other novel drug delivery systems. Spray drying was done to produce an inhalable, dry, powdered form of drug-loaded LPN. The spray-dried (SD) powder was equally capable of producing nano-aggregates having morphology, density, flowability and reconstitutibility in the range ideal for inhaled drug delivery. The nano aggregates produced by spray drying manifested their aerosolization efficiency in terms of the higher emitted dose and fine particle fraction with lower mass median aerodynamic diameter. The in vivo study using pharmacokinetic and pharmacodynamic approaches revealed that maximum internalization efficiency was achieved by delivering LPN in SD powdered forms by pulmonary route.

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A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid–polymer hybrid nanoparticles

Cited by 140 publications

References 21 publications

Isolation and Characterization of Novel Antimicrobial Peptides from Selected Plant Species

Isolation and Characterization of Novel Antimicrobial Peptides from Selected Plant Species

Dry Powder Inhalers: A Focus on Advancements in Novel Drug Delivery Systems

Pulmonary delivery of antitubercular drugs using spray-dried lipid–polymer hybrid nanoparticles

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