A comparison between SARS-CoV-1 and SARS-CoV2: an update on current COVID-19 vaccines

Abdolmaleki, Gelareh; Taheri, Mina; Paridehpour, Sarina; Mohammadi, Neshaut Mashreghi; Tabatabaei, Yasaman Ahmadi; Mousavi, Taraneh; Amin, Mohsen

doi:10.1007/s40199-022-00446-8

Cited by 13 publications

(12 citation statements)

References 174 publications

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“…Nesse contexto, a literatura aponta que o vírus infecta todas as faixas etárias e sexo, no entanto, vem sendo observada uma prevalência no sexo masculino e, principalmente, nos que possuem doenças crônicas dentre os mais gravemente afetados (19) . Ressalta-se que diferenças de sexo relacionadas à infecção por SARS-CoV-2 já foram observadas em epidemia anterior (20) .…”

Section: Discussionunclassified

Increased risk of mortality from COVID-19 in people with obesity

Ribeiro

Poli²,

Uehara³

2023

Rev Rene

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Objective: to analyze the risk of mortality from COVID-19 in people with obesity. Methods: observational, retrospective, and analytical study. Data were collected in the State System of Data Analysis. For the comparative analysis of people with and without obesity, n=168,808 was adopted. The analyses were performed using the log-binomial regression model and relative risk calculation. The comparative model was adjusted for sex, age group, heart disease and diabetes. Results: in more than 95% of COVID-19 notifications, information regarding the risk factor obesity was recorded as ignored. Obese individuals with COVID-19 had 26% higher risk of death when compared to those without obesity. Obese individuals in the 11 to 60 age groups had the highest mortality risks compared to individuals without obesity. Obese women in the age groups 31 to 50 years and elderly women over 71 years had the lowest mortality risk when compared to obese men. Conclusion: obese people, especially adults, have an increased risk of mortality from COVID-19. Contributions to practice: to help establish public health strategies to identify the profiles of individuals considered at high risk in the SARS-CoV-2 pandemic.

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Section: Discussionunclassified

Increased risk of mortality from COVID-19 in people with obesity

Ribeiro

Poli²,

Uehara³

2023

Rev Rene

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“…At the same time, the HLA-B*15:03 allele reportedly protects SARS-CoV-2 from host immune response [155] . Whereas HLA-B*07:03 , HLA-B*08:01 and HLA-B*46:01 are associated with susceptibility and resistance against SARS-CoV [152] . Another set of proteins, defensins (α, β, and θ defensins) rich in cysteine, are reported to act against bacteria, fungi and viruses as the first line of defence.…”

Section: Epigenetic Regulation Of Immunocompetence Related Genes Duri...mentioning

confidence: 99%

“…SARS-CoV and SARS-CoV-2 share 79.6 % of genomic similarity and use ACE2 receptors for their internalization; therefore, their pathophysiology closely resembles each other [152] . Both of them cause hyper-inflammation in the airways leading to their damage.…”

Section: Epigenetic Regulation Of Immunocompetence Related Genes Duri...mentioning

confidence: 99%

“…SARS-CoV infection leads to the accumulation of H3K4me1 and depletion of H3K27me3. H3K4me1 enhances the transcription of genes required for replication of SARS-CoV, but during MERS-CoV infection, a reverse phenomenon is seen, as there is more accumulation of H3K27me3 and depletion of H3K4me1 [152] , [157] . MERS-CoV and SARS-CoV infection are reportedly triggered by TMPRSS 2 , which is also responsible for SARS-CoV2 infection by proteolytic cleavage of ACE2 for the entry of the virus.…”

Section: Epigenetic Regulation Of Immunocompetence Related Genes Duri...mentioning

confidence: 99%

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Involvement of epigenetics in affecting host immunity during SARS-CoV-2 infection

Behura

Naik

Patel

et al. 2023

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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“…Many on-going and completed research works on ACE2 and its expression studies on the prostate shows that the prostate is most susceptible to COVID 19 infection (Song et al 2020;Abdolmaleki et al 2022). The double-positive cells with both ACE2 and TMPRSS2 expression can act as a medium or reservoir of COVID 19 infection (Singh et al 2020;Tanaka et al 2022).…”

Section: Expression Of Ace2 In the Prostatementioning

confidence: 99%

Angiotensin Converting Enzyme 2 (ACE2) - A macromolecule and its impact on human reproduction during COVID-19 pandemic

2022

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Coronavirus disease 2019 (COVID 19) is caused by severe acute respiratory syndrome novel coronavirus 2 (SARS-nCoV-2). It has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Since then, several researchers have worked/ are working on this virus by a multifactorial approach to finding out the mechanism of entry, transmission route, post-infection replication process, survival, and post-recovery utilities. As we know, SARS, MERS, and Zika viruses have affected human reproductive potentials, consequently, COVID 19 also can affect both men's and women's reproductive potential through ACE2 macromolecule. This study aimed to summarize the role of ACE2- macromolecule in COVID 19 entry and further processes in the reproductive path of both men and women. Research articles were searched in NCBI-NLM, Google Scholar, and Scopus databases. We searched based on the phrase “COVID 19”, “ACE2”, “ACE2 in testes”, “ACE2 in the female reproductive tract”, “ACE2 during pregnancy”, “ACE2 during early embryo”, “COVID 19 and impact in human reproduction” and selected the articles for summarizing this article. Most recent articles and the mechanism of COVID 19 were selected for our understanding. The results of the study revealed that COVID 19 impacts the reproductive potential of both men and women. Testes are the most vulnerable organ prone to infection in men, and vaginal fluid and the uterus could be the choice of infection in the female. Till now, COVID 19 has not been directly detected in semen samples and vaginal fluid. Results of the study can be concluded that ACE2 plays a major role in COVID 19 infection, ACE2 expression could be more in the testes, ovary, uterus, and vagina. COVID 19 could impact more on human reproduction and lead to a loss of fertility status for a while. All antiviral treatments could pose a negative impact on human reproduction. Further research should be carried out on the already existing theoretical hypothesis of SARS-Co-V-2 on human reproduction.

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A comparison between SARS-CoV-1 and SARS-CoV2: an update on current COVID-19 vaccines

Cited by 13 publications

References 174 publications

Increased risk of mortality from COVID-19 in people with obesity

Increased risk of mortality from COVID-19 in people with obesity

Involvement of epigenetics in affecting host immunity during SARS-CoV-2 infection

Angiotensin Converting Enzyme 2 (ACE2) - A macromolecule and its impact on human reproduction during COVID-19 pandemic

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