A comparison between plain eugenol and eugenol-loaded chitosan nanoparticles for prevention of in vitro selenite-induced cataractogenesis

Anand, T.; Anbukkarasi, Muniyandi; Thomas, Philip A.; Geraldine, Pitchairaj

doi:10.1016/j.jddst.2021.102696

Cited by 11 publications

(8 citation statements)

References 48 publications

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“…The PDI measurements are represented as numerical values (ranging from 0.0 to 1.0), where lower PDI values indicate higher stability. Accordingly, the attained PDI values for synthesized nanoparticles/composites here indicate the particle tendency toward polydispersion ( Keawchaoon and Yoksan, 2011 ; Woranuch and Yoksan, 2013 ; Anand et al, 2021 ).…”

Section: Resultsmentioning

confidence: 67%

“…The largest Ps mean was recorded after loading NCt with both Cur and Eug (364.7 nm). The used concentrations and fabrication procedure were effective for generating tiny Ps and elevated surface charges, compared with recent investigations for preparing parallel nanoconjugates ( Agustinisari et al, 2020 ; Almutairi et al, 2020 ; Anand et al, 2021 ).…”

Section: Resultsmentioning

confidence: 98%

“…Although the plain NCt does not regularly exhibit detectable cytotoxicity toward cells ( Chuah et al, 2014 ), it can provide great enforcement and augmentation to the anticancer bioactivities/cytotoxicities of natural products and drugs when NCt was used as a carrying/delivering agent for these compounds ( Almutairi et al, 2020 ; Detsi et al, 2020 ; Mazzotta et al, 2020 ; Anand et al, 2021 ). NCt was stated as the ideal biopolymeric system for delivering candidate anticancer drugs ( Ahmad et al, 2021 ); the NCt’s positive charges and adsorption capacities facilitate its attachment to cancerous cells and delivering the anticancer compound into the cells ( Detsi et al, 2020 ; Mazzotta et al, 2020 ; Ahmad et al, 2021 ).…”

Section: Resultsmentioning

confidence: 99%

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Fabrication and assessment of potent anticancer nanoconjugates from chitosan nanoparticles, curcumin, and eugenol

El‐Sherbiny

Elekhtiar

El‐Hefnawy

et al. 2022

Front. Bioeng. Biotechnol.

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In cancer management and control, the most challenging difficulties are the complications resulting from customized therapies. The constitution of bioactive anticancer nanoconjugates from natural derivatives, e.g., chitosan (Ct), curcumin (Cur), and eugenol (Eug), was investigated for potential alternatives to cancer cells’ treatment. Ct was extracted from Erugosquilla massavensis (mantis shrimp); then, Ct nanoparticles (NCt) was fabricated and loaded with Cur and/or Eug using crosslinking emulsion/ionic-gelation protocol and evaluated as anticancer composites against CaCo2 “colorectal adenocarcinoma” and MCF7 “breast adenocarcinoma” cells. Ct had 42.6 kDa molecular weight and 90.7% deacetylation percentage. The conjugation of fabricated molecules/composites and their interactions were validated via infrared analysis. The generated nanoparticles (NCt, NCt/Cur, NCt/Eug, and NCt/Cur/Eug composites) had mean particle size diameters of 268.5, 314.9, 296.4, and 364.7 nm, respectively; the entire nanoparticles carried positive charges nearby ≥30 mV. The scanning imaging of synthesized nanoconjugates (NCt/Cur, NCt/Eug, and NCt/Cur/Eug) emphasized their homogenous distributions and spherical shapes. The cytotoxic assessments of composited nanoconjugates using the MTT assay, toward CaCo2 and MCF7 cells, revealed elevated anti-proliferative and dose-dependent activities of all nanocomposites against treated cells. The combined nanocomposites (NCt/Eug/Cur) emphasized the highest activity against CaCo2 cells (IC50 = 11.13 μg/ml), followed by Cur/Eug then NCt/Cur. The exposure of CaCo2 cells to the nanocomposites exhibited serious DNA damages and fragmentation in exposed cancerous cells using the comet assay; the NCt/Eug/Cur nanocomposite was the most forceful with 9.54 nm tail length and 77.94 tail moment. The anticancer effectuality of innovatively combined NCt/Cur/Eug nanocomposites is greatly recommended for such biosafe, natural, biocompatible, and powerful anticancer materials, especially for combating colorectal adenocarcinoma cells, with elevated applicability, efficiency, and biosafety.

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Section: Resultsmentioning

confidence: 67%

Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

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Fabrication and assessment of potent anticancer nanoconjugates from chitosan nanoparticles, curcumin, and eugenol

El‐Sherbiny

Elekhtiar

El‐Hefnawy

et al. 2022

Front. Bioeng. Biotechnol.

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“…Another work in which TQ was encapsulated in pegylated polylactide co-glycolide nanoparticles (TF-PEG-PLGA-TQ NPs) for the treatment of non-small cell lung carcinoma achieved a maximum of 50% cumulative release of TQ in 24 h at pH 7.4, showing a faster release than NPCH-TQ due to the more hydrophilic nature of PEG-PLGA, facilitating the release of the hydrophobic compound from raw materials [35]. More hydrophilic terpenes, such as eugenol, showed a faster release than the TQ profile encapsulated in chitosan nanoparticles, with a maximum release of 73% at 36 h [36].…”

Section: Discussionmentioning

confidence: 97%

Thymoquinone-Loaded Chitosan Nanoparticles as Natural Preservative Agent in Cosmetic Products

Mondéjar-López

López-Jiménez

Garcı́a-Martı́nez

et al. 2022

IJMS

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The current status of controversy regarding the use of certain preservatives in cosmetic products makes it necessary to seek new ecological alternatives that are free of adverse effects on users. In our study, the natural terpene thymoquinone was encapsulated in chitosan nanoparticles. The nanoparticles were characterized by DLS and TEM, showing a particle size of 20 nm. The chemical structure, thermal properties, and release profile of thymoquinone were evaluated and showed a successful stabilization and sustained release of terpenes. The antimicrobial properties of the nanoparticles were evaluated against typical microbial contaminants found in cosmetic products, showing high antimicrobial properties. Furthermore, natural moisturizing cream inoculated with the aforementioned microorganisms was formulated with thymoquinone-chitosan nanoparticles to evaluate the preservative efficiency, indicating its promising use as a preservative in cosmetics.

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“…The supernatant was collected with their absorption spectra recorded in the wavelength range of 200−400 nm. 21 2.6.2. Zetasizer Analysis.…”

Section: 5mentioning

confidence: 99%

Carvacrol-Fabricated Chitosan Nanoparticle Synergistic Potential with Topoisomerase Inhibitors on Breast and Cervical Cancer Cells

Akhlaq,

Ashraf,

Omer

et al. 2023

ACS Omega

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Breast and cervical cancers are the most common heterogeneous malignancies in women. Chemotherapy with conventional drug delivery systems having several limitations along with development of multidrug resistance compelled us to seek out targeted therapeutics. Nanoparticles are suitable substitutes to circumvent multidrug resistance for the targeted treatment of cancer. The current study was aimed to investigate the anticancer effect of carvacrolloaded chitosan nanoparticles with topoisomerase inhibitors. The average size of carvacrol-loaded chitosan nanoparticles was found to be 80 nm with 24.7 mV ζpotential, and maximum absorbance was observed at 275 nm. Among all drug combinations, the carvacrol nanoparticles with the doxorubicin combination group exerted greater dose-dependent growth inhibition of both MCF-7 and HeLa cells as compared to single carvacrol nanoparticles and doxorubicin. Combination index values of carvacrol nanoparticles and the doxorubicin combination group showed a strong synergistic effect as they were found to be between 0.2 and 0.4, 0.31 for MCF-7 and 0.34 for HeLa cells. The carvacrol nanoparticles in combination with doxorubicin on MCF-7 cells reduced the dose 16.32-fold for carvacrol nanoparticles and 4.09-fold for doxorubicin at 6.23 μg/mL IC 50 , while on HeLa cells, this combination reduced the dose 13.18-fold for carvacrol nanoparticles and 3.83-fold for doxorubicin at 9.33 μg/mL IC 50 . As the dose reduction values were greater than 1, they indicated favorable dose reduction. It was concluded that the combination of carvacrol-loaded chitosan nanoparticles with topoisomerase inhibitors may represent an innovative and promising strategy to improve the efficacy, resistance, and targeted delivery of chemotherapeutics in cancer.

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A comparison between plain eugenol and eugenol-loaded chitosan nanoparticles for prevention of in vitro selenite-induced cataractogenesis

Cited by 11 publications

References 48 publications

Fabrication and assessment of potent anticancer nanoconjugates from chitosan nanoparticles, curcumin, and eugenol

Fabrication and assessment of potent anticancer nanoconjugates from chitosan nanoparticles, curcumin, and eugenol

Thymoquinone-Loaded Chitosan Nanoparticles as Natural Preservative Agent in Cosmetic Products

Carvacrol-Fabricated Chitosan Nanoparticle Synergistic Potential with Topoisomerase Inhibitors on Breast and Cervical Cancer Cells

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