A Comparison Between Low-Dose-Rate Brachytherapy With or Without Androgen Deprivation, External Beam Radiation Therapy With or Without Androgen Deprivation, and Radical Prostatectomy With or Without Adjuvant or Salvage Radiation Therapy for High-Risk Prostate Cancer

Ciezki, Jay P.; Weller, Michael; Reddy, Chandana A.; Kittel, J. A.; Singh, Harguneet; Tendulkar, Rahul D.; Stephans, Kevin L.; Ulchaker, James; Angermeier, Kenneth W.; Stephenson, Andrew J.; Campbell, Steven C.; Haber, Georges Pascal; Klein, Eric A.

doi:10.1016/j.ijrobp.2016.12.014

Cited by 48 publications

(58 citation statements)

References 38 publications

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“…Patients who received EBRT with an in situ pouch experienced worse function during EBRT and never fully returned to their baseline at a median follow up of 90 months. The difference seen in our functional results compared with urological studies may be related to the administration of brachytherapy, which has less bowel toxicity than EBRT . Interestingly, none of the patients required pouch excision.…”

Section: Discussionmentioning

confidence: 65%

Does external beam radiation therapy to the pelvis portend worse ileal pouch outcomes? An international multi‐institution collaborative study

et al. 2018

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Aim Short‐term morbidity and long‐term functional outcome of patients with an ileal pouch‐anal anastomosis (IPAA) exposed to pelvic external beam radiation therapy (EBRT) remains unknown. We report the largest series to date regarding the effects of pelvic EBRT on: (i) 30‐day postoperative outcomes; and (ii) long‐term functional outcome following IPAA. Method A retrospective chart review was conducted of patients who received EBRT before or after IPAA between 1980 and 2017 across three international inflammatory bowel disease referral centres. Results Nineteen patients were included. Indications for EBRT were rectal adenocarcinoma (n = 13), prostate adenocarcinoma (n = 4) or anal squamous cell carcinoma (ASCC) (n = 2). EBRT was given prior to IPAA in 12 (63%) patients and after IPAA in seven (37%). In EBRT before IPAA, patients had a median of 5 (range: 4–8) daytime bowel movements, 1 (range: 0–5) night‐time bowel movement, no daytime incontinence, and only one patient used pads at a median follow up of 25 (range: 11–163) months; one patient underwent pouch excision 15 months after IPAA. In EBRT after IPAA, patients reported a median of 8 (range: 5–10) daytime and 2 (range: 0–5) night‐time bowel movements, 80% had either daytime or night‐time incontinence and 80% used pads at a median follow up of 90 (range: 25–315) months. Conclusion Pelvic EBRT administered prior to IPAA is associated with acceptable long‐term function outcome. However, when pelvic EBRT is given to an IPAA in situ, most patients experience poor long‐term pouch function without pouch failure.

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Section: Discussionmentioning

confidence: 65%

Does external beam radiation therapy to the pelvis portend worse ileal pouch outcomes? An international multi‐institution collaborative study

et al. 2018

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“…Brachytherapy monotherapy can yield excellent outcomes for National Cancer Center Network (NCCN) low, intermediate, and even high risk disease 2–6 . NCCN Guidelines include brachytherapy as monotherapy for low risk and low-volume intermediate risk disease.…”

Section: Introductionmentioning

confidence: 99%

“…1 Brachytherapy monotherapy can yield excellent outcomes for patients with National Comprehensive Cancer Network (NCCN) lowrisk, intermediate-risk, and even high-risk disease. [2][3][4][5][6] NCCN guidelines include brachytherapy as monotherapy for patients with low-risk and low-volume intermediate-risk disease. Furthermore, brachytherapy is included as an optional boost after external beam radiotherapy (EBRT) for patients with intermediate-risk and high-risk disease.…”

Section: Introductionmentioning

confidence: 99%

Long‐term outcomes of partial prostate treatment with magnetic resonance imaging‐guided brachytherapy for patients with favorable‐risk prostate cancer

King

Nguyen

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et al. 2018

Cancer

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“…In terms of toxicity and cumulative incidence of three or more AEs, our work ranks at the lower end of comparable studies .…”

Section: Discussionmentioning

confidence: 95%

Long‐term oncological and functional follow‐up in low‐dose‐rate brachytherapy for prostate cancer: results from the prospective nationwide Swiss registry

et al. 2020

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P.V. and P.M.P. are sharing first authorship. ObjectiveTo evaluate the long-term oncological, functional and toxicity outcomes of low-dose-rate brachytherapy (LDR-BT) in relation to risk factors and radiation dose in a prospective multicentre cohort. ConclusionOur results are in line with other studies showing that LDR-BT is associated with good oncological outcomes together with good functional results.

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A Comparison Between Low-Dose-Rate Brachytherapy With or Without Androgen Deprivation, External Beam Radiation Therapy With or Without Androgen Deprivation, and Radical Prostatectomy With or Without Adjuvant or Salvage Radiation Therapy for High-Risk Prostate Cancer

Cited by 48 publications

References 38 publications

Does external beam radiation therapy to the pelvis portend worse ileal pouch outcomes? An international multi‐institution collaborative study

Does external beam radiation therapy to the pelvis portend worse ileal pouch outcomes? An international multi‐institution collaborative study

Long‐term outcomes of partial prostate treatment with magnetic resonance imaging‐guided brachytherapy for patients with favorable‐risk prostate cancer

Long‐term oncological and functional follow‐up in low‐dose‐rate brachytherapy for prostate cancer: results from the prospective nationwide Swiss registry

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