A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003

Xiong, Xiaoli; Chua, Gilbert T.; Chi, Shuiqing; Kwan, Mike Yat Wah; Wong, Wilfred Hing Sang; Zhou, Aifen; Shek, Chi Chiu; Tung, Keith T. S.; Qin, Huan; Wong, Rosa S.; Li, Xue; Chen, Peng; Li, Shuai; Chui, Celine S L; Tso, Winnie W. Y.; Ho, Marco H. K.; Wong, Ian C K; Chan, Godfrey C. F.; Lau, Yu Lung; Wong, Kenneth Kak Yuen; Chung, Patrick Ho Yu; Li, Hui; Tam, Paul Kwong Hang; Tang, Shaotao; Ip, Patrick

doi:10.1016/j.jpeds.2020.06.041

Cited by 28 publications

(24 citation statements)

References 32 publications

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“…To calculate the prevalence of headache in COVID-19, full-text assessment resulted in the exclusion of 123 articles for the following reasons: case control studies (n=2), case report studies (n=69), case series (n=29), duplicated dataset (n=1), and conducted in specific population only (n=23). The targeted population studies were conducted among healthcare workers 28 – 31 , diabetic patients 32 , pediatrics 33 , pregnant women 34 , cancer patients 35 , children and young adults 36 – 40 , patient undergone surgery 41 , critical patients 42 , women undergone delivery 43 , patients with mild-moderate COVID-19 44 – 46 , patients with gastrointestinal symptoms 47 , patients with severe headache only 48 , and patients with anosmia only 49 . In total, 78 studies were included to calculate the prevalence of headache in COVID-19 and all studies were published in 2020.…”

Section: Resultsmentioning

confidence: 99%

Global prevalence and pathogenesis of headache in COVID-19: A systematic review and meta-analysis

et al. 2021

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Background: This study was conducted to determine the prevalence of headache in coronavirus disease 2019 (COVID-19) and to assess its association as a predictor for COVID-19. This study also aimed to discuss the possible pathogenesis of headache in COVID-19. Methods: Available articles from PubMed, Scopus, and Web of Science were searched as of September 2nd, 2020. Data on characteristics of the study, headache and COVID-19 were extracted following the PRISMA guidelines. Biases were assessed using the Newcastle-Ottawa scale. The cumulative prevalence of headache was calculated for the general population (i.e. adults and children). The pooled odd ratio (OR) with 95% confidence intervals (95%CI) was calculated using the Z test to assess the association between headache and the presence of COVID-19 cases. Results: We included 104,751 COVID-19 cases from 78 eligible studies to calculate the global prevalence of headache in COVID-19 and 17 studies were included to calculate the association of headache and COVID-19. The cumulative prevalence of headache in COVID-19 was 25.2% (26,464 out of 104,751 cases). Headache was found to be more prevalent, approximately by two-fold, in COVID-19 patients than in non-COVID-19 patients (other respiratory viral infections), OR: 1.73; 95% CI: 1.94, 2.5 with p=0.04. Conclusion: Headache is common among COVID-19 patients and seems to be more common in COVID-19 patients compared to those with the non-COVID-19 viral infection. No definitive mechanisms on how headache emerges in COVID-19 patients but several possible hypotheses have been proposed. However, extensive studies are warranted to elucidate the mechanisms. PROSPERO registration: CRD42020210332 (28/09/2020)

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Section: Resultsmentioning

confidence: 99%

Global prevalence and pathogenesis of headache in COVID-19: A systematic review and meta-analysis

et al. 2021

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“…Alcuni studi retrospettivi hanno riportato alcune differenze nelle manifestazioni cliniche del Covid-19 rispetto a specifiche infezioni respiratorie osservate in età pediatrica. Un'analisi dei sintomi di pazienti con sindrome respiratoria acuta grave 2003 (SARS) e Covid-19 ha riscontrato che i pazienti con SARS presentano più frequentemente febbre, brividi, mialgia, malessere, rinite, mal di gola, tosse produttiva, nausea, cefalea e vertigini 13 . In rapporto ai pazienti con Influenza A, i pazienti con Covid-19 presentano più frequentemente febbre, diarrea o vomito, cefalea, dolore muscolare e toracico, mentre non sono state riportate differenze significative nel confronto con la sintomatologia dei pazienti affetti da Influenza B 14 .…”

Section: Discussioneunclassified

OctoberFAST: segni e sintomi dei bambini sottoposti a tampone per SARS-CoV-2

Carrozzo¹,

Bonicelli²,

Caldiani³

et al. 2021

M&B pagine elettroniche

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Background - From the beginning of the SARS-CoV-2 outbreak one major issue has been the early identification of infectious cases. It is particularly challenging to perform a symptom-based screening in the paediatric population because of the seeming overlap of early clinical manifestations between Covid-19 and other common viral infections. Aims - This study was aimed to assess the likelihood that clinical scenarios driving to the SARS-CoV-2 molecular swab test (SMST) might be suggestive for Covid-19 in children. Materials and methods - A survey was proposed to the family paediatricians of the Province of Bergamo (Italy). For all the patients referred for SMST due to symptoms in the period 28/Sep/2020 - 31/Oct/2020, the request was to gather the following data: symptoms, outcome of the SMST, school level, and period between onset of symptom/s and SMST. Data were centralised in anonymous format, making use of pivot-table with aggregate data for final statistical analysis. Results - Data were exploitable for 75 family paediatricians, for a total 3,093 SMST. SMST were positive in 119 cases (3.85%). The rate of SMST positivity was: 1) higher when the interval between symptoms and SMST was shorter than 24h; 2) slightly higher at middle school vs. pre-school or elementary school. Among the observed symptoms, a robust positive association with SMST positivity was observed (OR = 7.77) with a high PPV (22.5%) only for anosmia/ageusia. Conclusion - Although this study detected a few more suggestive signs/symptoms for Covid-19 with respect to other common viral illnesses, a symptom-based screening for SARS-CoV-2 appears less effective to flush out the virus in children. The estimation of the pre-test probability should also rely on the concurrent evaluation of the epidemiological setting.

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“…Simple measures that appeared to be useful during the SARS epidemic such as temperature screening [ 25 ] may not be sufficient for the COVID-19 pandemic. Compared to the high number of asymptomatic COVID-19 cases, the majority of SARS cases presented with fever, but serological study showed asymptomatic SARS carriers were extremely rare [ 26 , 27 ]. Nevertheless, other measures such the universal use of face masks, border controls, and mandatory self-quarantine policies for travellers returning from high-risk areas should be kept in place until an effective COVID-19 vaccine becomes available [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 in children across three Asian cosmopolitan regions

Chua

Xiong

Choi

et al. 2020

Emerging Microbes & Infections

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As another wave of COVID-19 outbreak has approached in July 2020, a larger scale COVID-19 pediatric Asian cohort summarizing the clinical observations is warranted. Children confirmed with COVID-19 infection from the Republic of Korea, the Hong Kong Special Administrative Region (HKSAR) and Wuhan, China, during their first waves of local outbreaks were included. Their clinical characteristics and the temporal sequences of the first waves of local paediatric outbreaks were compared. Four hundred and twenty three children with COVID-19 were analyzed. Wuhan had the earliest peak, followed by Korea and HKSAR. Compared with Korea and Wuhan, patients in HKSAR were significantly older (mean age: 12.9 vs. 10.8 vs. 6.6 years, p < 0.001, respectively) and had more imported cases (87.5% vs. 16.5% vs. 0%, p < 0.001, respectively). The imported cases were also older (13.4 vs. 7.6 years, p < 0.001). More cases in HKSAR were asymptomatic compared to Korea and Wuhan (45.5% vs. 22.0% vs. 20.9%, p < 0.001, respectively), and significantly more patients from Wuhan developed fever (40.6% vs. 29.7% vs. 21.6%, p =0.003, respectively). There were significantly less imported cases than domestic cases developing fever after adjusting for age and region of origin ( p = 0.046). 5.4% to 10.8% of patients reported anosmia and ageusia. None developed pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PMIS-TS). In general, adolescents were more likely to be asymptomatic and less likely to develop fever, but required longer hospital stays. In conclusion, majority patients in this pediatric Asian cohort had a mild disease. None developed PIMS-TS. Their clinical characteristics were influenced by travel history and age.

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A Comparison Between Chinese Children Infected with Coronavirus Disease-2019 and with Severe Acute Respiratory Syndrome 2003

Cited by 28 publications

References 32 publications

Global prevalence and pathogenesis of headache in COVID-19: A systematic review and meta-analysis

Global prevalence and pathogenesis of headache in COVID-19: A systematic review and meta-analysis

OctoberFAST: segni e sintomi dei bambini sottoposti a tampone per SARS-CoV-2

COVID-19 in children across three Asian cosmopolitan regions

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