A comparative ultrastructural study of chondrosarcoma, chordoid sarcoma, chordoma and chordoma periphericum

Povýšil, C; Matéjovský, Z

doi:10.1016/s0344-0338(85)80196-5

Cited by 48 publications

(15 citation statements)

References 30 publications

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“…As the chordoma has a predilection for the axial skeleton, extra-axial chordoma is presented as a rarer entity. Actually, only a few reports have described extra-axial sites of chordoma such as both limbs, soft tissue of the chest wall, pelvic bone, and hip muscle [4,5,6,7,8]. However, there are no reports that deal with extra-axial chordoma originating from the lung parenchyma.…”

Section: Introductionmentioning

confidence: 99%

Extra-Axial Chordoma Presenting as a Lung Mass

Park

Kim²,

Choe³

et al. 2008

Respiration

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Chordomas are slow-growing, malignant tumors of bone that are thought to be derived from the primitive notochord and occur almost exclusively in the axial skeleton. The so-called extra-axial chordoma has been shown to demonstrate identical features to the classic chordoma, except that it is found outside the axial skeleton. Only six cases of extra-axial chordoma have been reported in the literature to date. In this report, we present another case of extra-axial chordoma for the first time originating from the lung parenchyma. A 79-year-old man presented a 7.3-cm-sized cavitary lung mass. Pathologic examination, including immunohistochemical studies, revealed that the mass was a chordoma. We report an extra-axial chordoma for the first time presenting as a lung mass.

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Section: Introductionmentioning

confidence: 99%

Extra-Axial Chordoma Presenting as a Lung Mass

Park

Kim²,

Choe³

et al. 2008

Respiration

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“…However, chondroblastic differentiation has been supported by ultrastructural (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) and histochemical (16 -18) studies. In addition, cytogenetic and molecular analyses have shown that EMC is a distinct entity with the characteristic translocation t(9;22) involving the EWS gene (22q12) and the TEC gene (9q22) in a majority of the cases (19 -29).…”

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confidence: 99%

Extraskeletal Myxoid Chondrosarcoma: A Clinicopathologic, Immunohistochemical, and Ploidy Analysis of 23 Cases

et al. 2000

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Twenty-three cases of extraskeletal myxoid chondrosarcoma, evaluated at the Mayo Clinic between 1968 and 1996, were studied for clinicopathologic features, immunohistochemical profile, Ki-67 activity, and ploidy status to identify adverse prognostic factors. Females and males were equally affected, and the median age at diagnosis was 50 years. The tumors were located mainly in the lower extremities (83%), and the median tumor size was 9.5 cm. Sixteen tumors showed low cellularity (70%), and eight tumors had high mitotic activity (more than two per 10 high-power fields). The tumors were immunoreactive for vimentin (89%), synaptophysin (72%), epithelial membrane antigen (28%), and S-100 protein (17%). Nine tumors were diploid, three aneuploid, and one tetraploid. Mean Ki-67 activity was 11% (range, 1 to 45%). The 10-year overall survival rate was 78%. On univariate analysis, tumor size > 10 cm, high cellularity, presence of anaplasia or rhabdoid features, mitotic activity more than two per 10 high-power fields, Ki-67 > 10%, and Ki-67 "hot spot" > 25% were associated with decreased metastasis-free or overall survival. Ploidy status was not associated with any adverse outcome. The presence of any of these adverse prognostic factors can indicate the possibility of a more aggressive behavior in extraskeletal myxoid chondrosarcoma, and a closer follow-up is suggested. ) reassessed the clinical features of EMC in a series of 10 patients and showed the "indolent but resilient" nature of this neoplasm; 7 of the patients died of tumor up to 17 years after the initial diagnosis. Seven years later, Meis-Kindblom et al. (4) studied a large series of EMCs, most consultation cases, and showed that older age, larger tumor size, and proximal tumor location were associated with decreased survival by multivariate analysis.The histogenesis of EMC is still a subject of controversy. However, chondroblastic differentiation has been supported by ultrastructural (5-15) and histochemical (16 -18) studies. In addition, cytogenetic and molecular analyses have shown that EMC is a distinct entity with the characteristic translocation t(9;22) involving the EWS gene (22q12) and the TEC gene (9q22) in a majority of the cases (19 -29).We reviewed the clinicopathologic, immunohistochemical, and ploidy features in a series of 23 cases of EMC evaluated at a single institution to identify potential prognostic factors associated with a more aggressive behavior. MATERIALS AND METHODSTwenty-three patients in whom EMC was diagnosed between 1968 and 1996 were included in this study. Eighteen patients with EMC were diagnosed and primarily treated at the Mayo Clinic, and five patients were referred by other institutions for additional treatment or evaluation. Fifteen cases from this series will be described in another article (30).

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“…[4] In 2003, World Health Organization (WHO) tumor classified parachordoma, mixed tumor of soft-tissue and myoepithelioma as the tumor whose purported origin is unknown. It is attributed to be ectopic rests of notochord, [5] Schwann cells, [6] myoepithelial cells [7] or specialized synovial cells [8] with no convincing evidence one way or another.…”

Section: Discussionmentioning

confidence: 99%

A case of parachordoma on the chest wall and literature review

et al. 2013

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Parachordoma is an extremely uncommon soft-tissue tumor, which mainly occurs in the deep soft-tissue of the distal parts of the limbs, such as deep fascia, muscle tendon, synovial or soft-tissue closed to the bone. Nevertheless, the literature reports about parachordoma on the thoracic wall were scarce. The clinical and imaging manifestation has a non-specific appearance. In this article, we reported one case of parachordoma of the thoracic wall that we met in clinical works and reviewed the literature.

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A comparative ultrastructural study of chondrosarcoma, chordoid sarcoma, chordoma and chordoma periphericum

Cited by 48 publications

References 30 publications

Extra-Axial Chordoma Presenting as a Lung Mass

Extra-Axial Chordoma Presenting as a Lung Mass

Extraskeletal Myxoid Chondrosarcoma: A Clinicopathologic, Immunohistochemical, and Ploidy Analysis of 23 Cases

A case of parachordoma on the chest wall and literature review

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