A comparative trial to optimize the protocol of the 13C urea breath test for the diagnosis of Helicobacter pylori infection

Zagari, R.M.; Pozzato, P.; Bazzoli, Franco; Fossi, S.; Ricciardiello, Luigi; Nicolini, G.; Berretti, D.; Luca, L. De; Alampi, G; Salfi, N.; Martinelli, G.; Sottili, S.; Festi, Davide; Neri, Matteo; Simoni, Patrizia; Roda, Ângela; Roda, Enrico

doi:10.1016/s0016-5085(98)81393-0

Cited by 3 publications

(3 citation statements)

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“…However, there is no universal agreement on the use of a lower than usual cut off value. Zagari and colleagues44 also used ROC analysis on a large sample of patients and were not able to decrease the cut off level below the value of 4.5‰ with either 75 mg or 100 mg doses of 13 C-urea. It must be stressed, however, that the 5‰ value remains a strong index for distinguishing infected subjects from uninfected ones and therefore this cut off value is still widely used.…”

Section: Cut Off Valuesmentioning

confidence: 99%

The 13C urea breath test in the diagnosis of Helicobacter pylori infection

Savarino

Vigneri

Celle

1999

Gut

159

117

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Section: Cut Off Valuesmentioning

confidence: 99%

The 13C urea breath test in the diagnosis of Helicobacter pylori infection

Savarino

Vigneri

Celle

1999

Gut

159

117

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“…The elevated diagnostic accuracy of 13 C-UBT carried out according to the European Standard Protocol has been confirmed by a comparative study of different 13 C-UBT protocols 18 . The use of a less than optimal protocol is certainly the principal cause of inaccuracy of the 13 C-UBT.…”

Section: Non-invasive Testsmentioning

confidence: 73%

“…The excess delta 13 CO 2 excretion per mil represents the 13 C enrichment over and above the pre-dose breath sample. 13 C-UBT is an accurate test for diagnosing H. pylori infection with a sensitivity and a specificity of 90-100%, both before 16-17 and after eradication treatment [18][19] .…”

Section: Non-invasive Testsmentioning

confidence: 99%

Helicobacter pylori: Optimum Diagnosis and Test of Cure

Bazzoli

Zagari²,

Pozzato³

et al. 1999

Journal of Chemotherapy

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The fact that about 50% of the world's population is infected with Helicobacter (H.) pylori and the important role that this bacterium plays in public health have been important incentives in the search for accurate diagnostic methods. A large number of invasive and non-invasive methods have been used to diagnose H. pylori infection. Each method has its advantages and disadvantages and each practitioner should choose the best diagnostic method according to the facilities available. Non-invasive tests for the diagnosis of H. pylori infection are largely used in clinical practice and in management of patients with gastroduodenal disease. Serology is the most widespread test but its use is not advised in the post-treatment follow-up. The Urea Breath Test is a simple, safe and highly accurate method ideal for evaluating the short-term follow-up of H. pylori eradication after therapy.

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Non-invasive diagnostic tests forHelicobacter pyloriinfection

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Takwoingi

Siddique

et al. 2018

Cochrane Database of Systematic Reviews

154

130

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In people without a history of gastrectomy and those who have not recently had antibiotics or proton ,pump inhibitors, urea breath tests had high diagnostic accuracy while serology and stool antigen tests were less accurate for diagnosis of Helicobacter pylori infection.This is based on an indirect test comparison (with potential for bias due to confounding), as evidence from direct comparisons was limited or unavailable. The thresholds used for these tests were highly variable and we were unable to identify specific thresholds that might be useful in clinical practice.We need further comparative studies of high methodological quality to obtain more reliable evidence of relative accuracy between the tests. Such studies should be conducted prospectively in a representative spectrum of participants and clearly reported to ensure low risk of bias. Most importantly, studies should prespecify and clearly report thresholds used, and should avoid inappropriate exclusions.

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A comparative trial to optimize the protocol of the 13C urea breath test for the diagnosis of Helicobacter pylori infection

Cited by 3 publications

References 0 publications

The 13C urea breath test in the diagnosis of Helicobacter pylori infection

The 13C urea breath test in the diagnosis of Helicobacter pylori infection

Helicobacter pylori: Optimum Diagnosis and Test of Cure

Non-invasive diagnostic tests forHelicobacter pyloriinfection

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