A Comparative Trial of a Single-Dose Ivermectin Versus Three Days of Albendazole for Treatment of Strongyloides Stercoralis and Other Soil-Transmitted Helminth Infections in Children

Marti, Hanspeter; Haji, Hamad J.; Savioli, Lorenzo; Chwaya, Hababu Mohammed; Mgeni, A. F.; Ameir, Juma Suleiman; Hatz, Christoph

doi:10.4269/ajtmh.1996.55.477

Cited by 248 publications

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“…Although not a randomized trial, albendazole's 14% failure rate reinforces its inferiority to thiabendazole or ivermectin. 19,34,35 Ivermectin 200 mcg/kg orally and repeated at 2 weeks has 97% efficacy. 34 Ivermectin is inactive against hookworm, a common co-infection.…”

Section: Discussionmentioning

confidence: 99%

Maltreatment of Strongyloides Infection: Case Series and Worldwide Physicians-in-Training Survey

Boulware

Stauffer

Hendel-Paterson

et al. 2007

The American Journal of Medicine

115

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Section: Discussionmentioning

confidence: 99%

Maltreatment of Strongyloides Infection: Case Series and Worldwide Physicians-in-Training Survey

Boulware

Stauffer

Hendel-Paterson

et al. 2007

The American Journal of Medicine

115

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“…33,34 In a study in Zanzibar, the effect of the two regimens was compared. A cure rate of 82.9% was achieved for ivermectin while three doses of albendazole cured 45.0% of the infected individuals.…”

Section: Treatmentmentioning

confidence: 99%

“…A cure rate of 82.9% was achieved for ivermectin while three doses of albendazole cured 45.0% of the infected individuals. 33 Most helminth control programmes employ mass drug administration as their principal tool; hence, they offer treatment without prior diagnosis. For control of soiltransmitted helminths, the target population is usually schoolchildren, but regular (e.g.…”

Section: Treatmentmentioning

confidence: 99%

Strongyloidiasis – the most neglected of the neglected tropical diseases?

Olsen

Lieshout

Marti

et al. 2009

Transactions of the Royal Society of Tropical Medicine and Hygi

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469

442

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a v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j o u r n a l h o m e p a g e : h t t p : / / w w w . e l s e v i e r . c o m / l o c a t e / t r s t m h Summary Soil-transmitted helminths of the genus Strongyloides (S. fuelleborni and the more prevalent S. stercoralis) are currently believed to infect an estimated 30-100 million people worldwide. The health consequences of S. stercoralis infections range from asymptomatic light infections to chronic symptomatic strongyloidiasis. Uncontrolled multiplication of the parasite (hyperinfection) and potentially life-threatening dissemination of larvae to all internal organs is found among individuals with compromised immune system functions. This paper provides an overview of the current state of the art in relation to diagnostic methods for detecting the infection, the morbidity caused by the infection and the recommended treatment. It further discusses some of the reasons why this infection is so neglected and the consequence of this for the estimated global prevalence. The paper finally points to the gaps in our knowledge and future research needs related to this infection. As Strongyloides infections have the potential to develop into severe disease in certain population subgroups, untreated infections could cause serious problems in the community. Therefore, we need to carefully investigate this parasite in order to develop and implement effective control programmes. REVIEW Strongyloidiasis

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“…Indeed, school-aged children were virtually all infected with at least one of the three common STHs, namely Ascaris lumbricoides , Trichuris trichiura, and hookworm ( Ancylostoma duodenale and Necator americanus ). 7,8 Additionally, infections with Strongyloides stercoralis , the most neglected STH species, 9 were found in one third of the children examined in the schools of Chaani and Kinyasini in Unguja. 8 In 1994, the Ministry of Health and Social Welfare (MoHSW) of Zanzibar, in collaboration with the World Health Organization (WHO), established an action plan for the control of STHs and urinary schistosomiasis.…”

Section: Introductionmentioning

confidence: 99%

Changing Patterns of Soil-Transmitted Helminthiases in Zanzibar in the Context of National Helminth Control Programs

Knopp¹,

Mohammed²,

Rollinson³

et al. 2009

The American Journal of Tropical Medicine and Hygiene

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Abstract. Helminth control programs have been implemented in Zanzibar for over a decade. In June/July 2007, ~6 months after the last school-based anthelmintic treatment, a cross-sectional survey was carried out in two schools, and results were compared with data obtained in the same schools in 1994. Multiple stool samples collected from 368 school children were subjected to the Kato-Katz, Koga agar plate, and Baermann methods. The prevalence of Trichuris trichiura , hookworm, Ascaris lumbricoides, and Strongyloides stercoralis was 46.6%, 21.6%, 16.9%, and 10.2%, respectively. Infection intensities were generally low. Compared with 1994, the prevalence of S. stercoralis , hookworm, A. lumbricoides, and T. trichiura decreased by 81.0%, 80.5%, 70.6%, and 48.6%, respectively. Infection intensities decreased by > 95% for all helminth species studied. Our study confirms that preventive chemotherapy successfully reduces the level and intensity of helminth infections. To consolidate achievements made, additional control measures such as health education and environmental sanitation are needed.

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A Comparative Trial of a Single-Dose Ivermectin Versus Three Days of Albendazole for Treatment of Strongyloides Stercoralis and Other Soil-Transmitted Helminth Infections in Children

Cited by 248 publications

References 0 publications

Maltreatment of Strongyloides Infection: Case Series and Worldwide Physicians-in-Training Survey

Maltreatment of Strongyloides Infection: Case Series and Worldwide Physicians-in-Training Survey

Strongyloidiasis – the most neglected of the neglected tropical diseases?

Changing Patterns of Soil-Transmitted Helminthiases in Zanzibar in the Context of National Helminth Control Programs

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