A Comparative Study to Evaluate the Efficacy of Curcumin Lozenges (TurmNova®) and Intralesional Corticosteroids with Hyaluronidase in Management of Oral Submucous Fibrosis

Srivastava, Rahul; Kundu, Atish; Pradhan, Devina; Jyoti, Bhuvan; Chokotiya, Heeralal; Parashar, Pranav

doi:10.5005/jp-journals-10024-3144

Cited by 11 publications

(33 citation statements)

References 15 publications

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“…Five hundred and five studies that did not fulfill the eligibility criteria were excluded. In total, nineteen studies [ 24 , 35 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] were included and processed for data extraction ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Nineteen RCTs were included [ 24 , 35 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. The number of participants ranged between 11 and 178 individuals.…”

Section: Resultsmentioning

confidence: 99%

“…The number of participants ranged between 11 and 178 individuals. Fifteen studies [ 24 , 35 , 39 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 49 , 50 , 51 , 52 , 54 ] reported the gender of the participants in which the number of males and females ranged from 15 to 44 and 9 to 46 individuals, respectively. In all studies [ 24 , 35 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ], individuals in the test group used turmeric products for the management of pain in the OFR.…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen studies [ 24 , 35 , 39 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 49 , 50 , 51 , 52 , 54 ] reported the gender of the participants in which the number of males and females ranged from 15 to 44 and 9 to 46 individuals, respectively. In all studies [ 24 , 35 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ], individuals in the test group used turmeric products for the management of pain in the OFR. In twelve studies [ 39 , 41 , 43 , 45 , 46 , 48 , 50 , 52 , 53 , 54 ], individuals in the control group used steroids for the management of pain in the OFR.…”

Section: Resultsmentioning

confidence: 99%

“…Data extraction from the nineteen eligible RCTs [ 24 , 35 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] was performed by two authors (BS, ER), and pertinent information was summarized according to the (a) reference, (b) number of subjects, (c) subject gender, (d) study groups, (e) subjects’ mean age and range, (f) source of OFP, (g) pain rating scale, (h) follow-up period, (i) study characteristics related to curcumin use, (j) type of control, (k) risk of bias, and (l) main study outcomes (reduction in self-rated pain levels) and conclusions.…”

Section: Methodsmentioning

confidence: 99%

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Effectiveness of Curcumin in Reducing Self-Rated Pain-Levels in the Orofacial Region: A Systematic Review of Randomized-Controlled Trials

Sterniczuk

Rossouw

Michelogiannakis

et al. 2022

IJERPH

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The aim was to systematically review randomized controlled trials (RCTs) that assessed the effectiveness of curcumin in reducing self-rated pain levels in the orofacial region (OFR). The addressed focused question was “Is curcumin effective in reducing self-rated pain levels in the OFR?”. Indexed databases (PubMed (National Library of Medicine), Scopus, EMBASE, MEDLINE (OVID), and Web of Science) were searched up to and including February 2022 using different keywords. The inclusion criteria were (a) original studies (RCTs) in indexed databases; and (b) studies assessing the role of curcumin in the management of pain in the OFR. The risk of bias was assessed using the Cochrane risk of bias tool. The pattern of the present systematic review was customized to primarily summarize the pertinent information. Nineteen RCTs were included. Results from 79% of the studies reported that curcumin exhibits analgesic properties and is effective in reducing self-rated pain associated with the OFR. Three studies had a low risk of bias, while nine and seven studies had a moderate and high risk of bias, respectively. Curcumin can be used as an alternative to conventional therapies in alleviating pain in the OFR. However, due to the limitations and risk of bias in the aforementioned studies, more high-quality RCTs are needed.

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