A comparative study to assess the effectiveness of curcumin, mucosamin, and chlorhexidine in chemotherapy-induced oral mucositis

Fardad, Farshid; Ghasemi, Katayoon; Ansarinejad, Nafiseh; Khodakarim, Nastaran; Nasiripour, Somayyeh; Farasatinasab, Maryam

doi:10.1016/j.explore.2022.04.009

Cited by 7 publications

(4 citation statements)

References 12 publications

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“…It is noteworthy that, at the end of the study, about 33% of the patients treated with curcumin-loaded mouthwash and about 15% of the patients receiving oral capsules had no ulcers, while in the placebo group all patients still had inflammatory symptoms. Similar conclusions have been made by Fardad et al [144] who compared the effectiveness of curcumin-loaded gel, mucosamin oral spray and chlorhexidine mouthrinse in the treatment of chemotherapy-induced oral mucositis. In a double-blind randomized study, they demonstrated that all three approaches were effective.…”

Section: Oral Mucositis and Mouth Ulcerssupporting

confidence: 84%

A Well-Known Plant and New Therapeutic Strategies: Turmeric and Its Components in Oral Inflammatory Diseases Treatment

Wojtyłko,

Kunstman,

Bartylak

et al. 2023

Applied Sciences

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Turmeric has been known for centuries as a spice and an important element of traditional medicine. Nowadays, plant-derived compounds are still an object of extensive scientific investigations aiming at the development of novel drugs and dosage forms. Turmeric and its most important component, curcumin, reveal numerous interesting biological properties, including antioxidant, anti-inflammatory and antimicrobial activity. Numerous scientific studies focusing on various aspects of the activity of turmeric-derived compounds show that curcuminoids display an enormous potential as active pharmaceutical ingredients useful in a wide spectrum of medical conditions. Oral diseases comprising both mild inflammations and severe life-threatening conditions are classified as the most common ones, affecting an enormous part of the global population. In this review, the current research regarding turmeric and its constituents in oral diseases is summarized and discussed, with special attention paid to novel findings and future directions regarding scientific exploration of curcuminoids.

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Section: Oral Mucositis and Mouth Ulcerssupporting

confidence: 84%

A Well-Known Plant and New Therapeutic Strategies: Turmeric and Its Components in Oral Inflammatory Diseases Treatment

Wojtyłko,

Kunstman,

Bartylak

et al. 2023

Applied Sciences

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“…The compound is often incorporated in oral health products because of its effectiveness in reducing plaque formation and in treating gingivitis [57]. Due to its bactericidal and bacteriostatic activity, chlorhexidine is frequently used in hospital environments for skin disinfection before surgical procedures [58,59].…”

Section: Discussionmentioning

confidence: 99%

Mouthwashes used in patients with oral and oropharyngeal mucositis: A systematic review

Costa,

Dias,

Rodrigues

et al. 2024

Preprint

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Purpose The aim of this study was to conduct a systematic review of randomized clinical trials in order to assess the efficacy of the following mouthwashes recommended for the prevention and treatment of OM and OPM in patients undergoing cancer treatment: chlorhexidine, allopurinol, benzydamine, and propolis. Methods The following research question was formulated based on the PICOS strategy: “Are chlorhexidine, allopurinol, benzydamine and propolis mouthwashes effective in preventing and treating OM and OPM in patients undergoing cancer treatment?” Searches were performed in PubMed, Embase, Scopus, and Web of Science, without publication year or language restrictions. Randomized clinical trials comparing the use of chlorhexidine, allopurinol, benzydamine and propolis with a control group not submitted to any intervention were included. The retrieved articles were analyzed and selected by two reviewers and disagreements were resolved by consultation with a third reviewer. After data extraction, two evaluators independently analyzed the methodological quality of the studies using the Cochrane tool. Results After evaluation of the works, 13 of 1183 articles were selected. mouthwashes containing propolis and benzydamine mouthwashes were promising and effective while chlorhexidine or allopurinol did not provide satisfactory results. Conclusion Mouthwashes could be an alternative for treatment or preventing oral mucositis in cancer patients Services could consider the possibility of incorporating these medications since, in most cases, they are low cost and donot require specialized staff in their use.

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“…In particular, the CUR-based option was more effective than the photo-treatment alone in both minimizing infections and reducing OM symptoms. A double-blind clinical trial comparing the effect of three formulations loaded with mucosamin, chlorhexidine, and CUR in the treatment of OM was performed by Fardad et al [68] in 2023. Specifically, 82 patients undergoing chemotherapy were divided into three groups treated with (i) commercially available Mucosamin ® oral spray (Professional Dietetics ® , Milan, Italy) four puffs/day for two weeks; (ii) commercially available 0.2% (w/v) chlorhexidine mouthwash (Behsa ® , Tehran, Iran) in 1:1 dilution for 1 min four times/day for two weeks; and (iii) 0.5% (w/v) CUR-loaded gel, four times/day for two weeks.…”

Section: Clinical Trialsmentioning

confidence: 99%

Plant-Derived Polyphenols to Prevent and Treat Oral Mucositis Induced by Chemo- and Radiotherapy in Head and Neck Cancers Management

Belfiore,

Di Prima,

Angellotti

et al. 2024

Cancers

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Oral Mucositis (OM) is the most common side effect due to chemotherapy and radiotherapy, which are the conventional treatment options for head and neck cancers. OM is a severe inflammatory condition characterized by multifactorial etiopathogenesis. It further negatively affects patients’ quality of life by severe impairment of normal oral functions. Consequently, it is mandatory to identify new effective therapeutic approaches to both prevent and treat OM while also avoiding any recurrence. Polyphenols recently attracted the interest of the scientific community due to their low toxicity and wide range of biological activities making them ideal candidates for several applications in the odontostomatological field, particularly against OM. This review collects the in vivo studies and the clinical trials conducted over the past 13 years evaluating the preventive and curative effects of several polyphenolic compounds towards chemo- and radiotherapy-induced OM, both when administered alone or as a plant-extracted phytocomplex. The literature fully confirms the usefulness of these molecules, thus opening the possibility of their clinical application. However, polyphenol limitations (e.g., unfavourable physicochemical properties and susceptibility to degradation) have emerged. Consequently, the interest of the scientific community should be focused on developing innovative delivery systems able to stabilize polyphenols, thus facilitating topical administration and maximizing their efficacy.

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A comparative study to assess the effectiveness of curcumin, mucosamin, and chlorhexidine in chemotherapy-induced oral mucositis

Cited by 7 publications

References 12 publications

A Well-Known Plant and New Therapeutic Strategies: Turmeric and Its Components in Oral Inflammatory Diseases Treatment

A Well-Known Plant and New Therapeutic Strategies: Turmeric and Its Components in Oral Inflammatory Diseases Treatment

Mouthwashes used in patients with oral and oropharyngeal mucositis: A systematic review

Plant-Derived Polyphenols to Prevent and Treat Oral Mucositis Induced by Chemo- and Radiotherapy in Head and Neck Cancers Management

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