A comparative study on the toxicity and mutagenicity of biphenyl (BP) and diphenyl ether (DPE) in sea urchin, S. typhimurium and S. cerevisiae

Bronzetti, G.; Esposito, A.; Pagano, Giovanni; Quinto, Ileana

doi:10.1016/0165-1161(81)90076-5

Cited by 4 publications

(1 citation statement)

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“…Nur bei dieser Dosierung war die Körperge-wichtszunahme verringert, außerdem verendeten 5 Muttertiere (Khera et al 1979). Brams et al 1987;Bronzetti et al 1981;Cline und McMahon 1977;Fujita et al 1985;Glatt et al 1992;Haworth et al 1983;Ishidate et al 1984;Kawachi et al 1980;NTP 1980;Pagano et al 1983Pagano et al , 1988Probst et (Sofuni et al 1985) als auch Genmutationen am HPRT-Locus (Glatt et al 1992). Die Induktion der HPRT-Mutationen war nicht von einer nachweisbaren Zytotoxizität der Behandlung begleitet.…”

Section: Entwicklungstoxizitätunclassified

Biphenyl [MAK Value Documentation in German language, 2001]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 32. Lieferung, Ausgabe 2001 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Erfahrungen beim Menschen Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Section: Entwicklungstoxizitätunclassified

Biphenyl [MAK Value Documentation in German language, 2001]

2012

The MAK‐Collection for Occupational Health and Safety

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Genotoxicity and teratogenicity of diphenyl and diphenyl ether: A study of sea urchins, yeast, andSalmonella typhimurium

Pagano

Esposito

Giordano

et al. 1983

Teratog. Carcinog. Mutagen.

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This study was designed to investigate the possible genotoxic and teratogenic actions of diphenyl (DP), diphenyl ether (DPE), and their eutectic mixture, in a comparative approach including different test systems. Two microbial systems and a metazoan model were used: (1) diploid D7 strain of Saccharomyces cerevisiae; (2) Salmonella typhimurium strains TA100, TA98, TA1535, TA1537, TA1538, TA1532, TA2636; and (3) sea urchins (Paracentrotus lividus and Sphearechinus granularis). Both compounds resulted in severe toxicity in all of test organisms at levels greater than or equal to 10(-5) M (approximately 2 ppm). DP caused genetic effects in yeast with and without activating system, while the two chemicals appeared to be ineffective in Salmonella up to toxic levels. The action of DP and DPE on sea urchins resulted in developmental defects and mitotic abnormalities, following exposure of embryos or by pretreatment of sperm or eggs. In this system DPE appeared to be more effective than DP by about one order of magnitude (minimal active concentrations: 10(-5) M vs 10(-4) M). The eutectic mixture, industrially used as a heat transfer medium, was tested in its virgin and used form, for genotoxicity and embryotoxicity. The latter appeared to be more effective than the virgin eutectic. This increase in the embryo- and genotoxicity of the used eutectic may be related to the appearance of newly formed compounds in the heat transfer process. These compounds have been separated by high-pressure liquid chromatography and detected by fluorimetry.

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Characterization of automotive emissions by bacterial mutagenesis bioassay: A review

Claxton

1983

Environ. mutagen

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Due to the growing numbers of diesel passenger automobiles in the United States, there has been an expanded effort to understand the health effects of airborne pollutants arising from increased automotive emissions. Bacterial mutagenicity testing has played an important role in the characterization of genotoxic effects and components arising from these combustion products. This review examines published material concerning the bacterial mutagenicity of automotive emissions. In addition, the paper explores factors that modify the mutagenicity of mobile-source emissions, the use of bacterial tests for the comparison of various mobile source emissions, and the use of bacterial tests to examine the phenomena of mammalian uptake and metabolism.

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A comparative study on the toxicity and mutagenicity of biphenyl (BP) and diphenyl ether (DPE) in sea urchin, S. typhimurium and S. cerevisiae

Cited by 4 publications

References 0 publications

Biphenyl [MAK Value Documentation in German language, 2001]

Biphenyl [MAK Value Documentation in German language, 2001]

Genotoxicity and teratogenicity of diphenyl and diphenyl ether: A study of sea urchins, yeast, andSalmonella typhimurium

Characterization of automotive emissions by bacterial mutagenesis bioassay: A review

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