A Comparative Study on the Interaction of Sulfonamide and Nanosulfonamide with Human Serum Albumin

Abstract

Binding parameters of the N-phenyl benzene sulfonyl hydrazide, sulfonamide, and nanosulfonamide interaction with human serum albumin were determined by calorimetry method. The obtained binding parameters indicated that sulfonamide in the second binding sites has higher affinity for binding than the first binding sites. The binding process of sulfonamide to HSA is both enthalpy and entropy driven. The associated equilibrium constants confirm that sulfonamide binds to HSA with high affinity (2.2×106and 3.86105 M−1for first and second sets of binding sites, resp.). The obtained results indicate that sulfonamide increases the HSA antioxidant property. Nanosulfonamide has much more affinity for HSA (3.6×106 M−1) than sulfonamide.

Microwave-assisted synthesis of 1,2,3,4-tetrahydroisoquinoline sulfonamide derivatives and their biological evaluation

“…In addition, it is known that sulfonamides bind to Sudlow site I by stabilizing the structure of the albumin molecule and increasing the anti-oxidant properties of albumin. 31 From the experiment we found out that the newly synthesized sulfonamides show better expressed ATA activity.…”

Synthesis and characterization of 4(3-(4-Fluorophenyl)2-methyl-1-(4-(sulfonamidesubtituted)phenyl)-4-oxoazitidin-2-yl)-3-methyl-1-(p-tolyl)-1H-pyrazol-5(4H)One as Antibacterial, and Antioxidant Candidates

“…They are highly reactive with free single electrons and rapidly bind to nearby molecules also they attack the molecules in adjacent cells therefore damage is unavoidable. Sulfonamide (-RSO2NH2) functionality is most useful as an antioxidant that inhibits oxidation, and the action of ROS in the other molecule 25,26,27,28 . Here in we explored and modified our continuing work from the explanations of our previous and some reported derivatives, it would be encouraging to synthesize new series of sulfonamide entities bearing 2-azitidinone, 4 (…”

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“…, Antimalarial [13], cysteine protease [14], hypoglycemic [15], influenza [16], Antioxidant [5], [17][18][19], anti tuberculosis [20][21][22], etc. Beside the azitidine, another small fused 4-membered 'N' containing heterocyclic ring having carbonyl group at second position therefore also known as βlactam and 2-azitidinone is one of the most potent pharmacophores showed famous drugs as cephalosporins, carbapenems, penicillin, monobactams, clavulanic acid, etc [23].…”