A comparative study on the nanoparticles for improved drug delivery systems

Mahmoodi, Nosrat O.; Ghavidast, Atefeh; Amirmahani, Najmeh

doi:10.1016/j.jphotobiol.2016.07.037

Cited by 57 publications

(25 citation statements)

References 101 publications

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“…The loading of the potential antitumor drug GA bestowed on the nanocarrier new antitumor efficacy. The combination of RBCm and PLGA has been shown to enhance the stability and biocompatibility of a composite carrier compared with bare nanoerythrosomes 43 and a polymeric carrier, 44 and we confirmed this in vitro. Moreover, GA-loaded RBC NPs lifted restrictions on the application of GA, which were due to its poor water solubility.…”

Section: Resultssupporting

confidence: 75%

Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment

Zhang

Yang

et al. 2017

IJN

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Gambogic acid (GA) is expected to be a potential new antitumor drug, but its poor aqueous solubility and inevitable side effects limit its clinical application. Despite these inhe rent defects, various nanocarriers can be used to promote the solubility and tumor targeting of GA, improving antitumor efficiency. In addition, a cell membrane-coated nanoparticle platform that was reported recently, unites the customizability and flexibility of a synthetic copolymer, as well as the functionality and complexity of natural membrane, and is a new synthetic biomimetic nanocarrier with improved stability and biocompatibility. Here, we combined poly(lactic- co -glycolic acid) (PLGA) with red blood-cell membrane (RBCm), and evaluated whether GA-loaded RBCm nanoparticles can retain and improve the antitumor efficacy of GA with relatively lower toxicity in colorectal cancer treatment compared with free GA. We also confirmed the stability, biocompatibility, passive targeting, and few side effects of RBCm-GA/PLGA nanoparticles. We expect to provide a new drug carrier in the treatment of colorectal cancer, which has strong clinical application prospects. In addition, the potential antitumor drug GA and other similar drugs could achieve broader clinical applications via this biomimetic nanocarrier.

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Section: Resultssupporting

confidence: 75%

Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment

Zhang

Yang

et al. 2017

IJN

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“…In continuation to our prior works [40][41][42][43][44][45] , we have synthesized modified magnetic Fe 3 O 4 @SiO 2 -TRIS NPs by the steps shown in Figure 1. First, Fe 3 O 4 NPs were prepared by the co-precipitation of Fe 2+ and Fe 3+ ions in a basic solution.…”

Section: Resultsmentioning

confidence: 93%

Adsorption of acid red 114 and reactive black 5 in aqueous solutions on dendrimer‐conjugated magnetic nanoparticles

Galangash

Ghavidast

Bozorgpanah

2018

J Chinese Chemical Soc

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The adsorption of the dyes Acid Red 114 and Reactive Black 5 in aqueous solutions on polyhydroxyl dendrimer magnetic nanoparticles (Fe3O4@SiO2‐TRIS) was studied in a batch system. The Fe3O4@SiO2‐TRIS NPs were characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, and transmission electron microscopy. Experiments were performed under different conditions such as the initial dye concentration, adsorbent dose, and pH. The pseudo‐second‐order model provided a very good fit for the two anionic dyes. The Langmuir and Freundlich adsorption models were used to describe the equilibrium isotherms at different temperatures, and the former agreed very well with the experimental data. However, the adsorption capacity of Fe3O4@SiO2‐TRIS NPs was reduced during surface modification, which could be due to the dye occupying the binding sites of the dendrimer. Thermodynamic parameters, namely the change in free energy (ΔG0), enthalpy (ΔH0), and entropy (ΔS0), were also determined.

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“…Importantly, AuNPs can be efficient in drug-resistant neoplasm [7]. Another advantage of the usage of AuNPs is a variety of sizes and possible surface modifications, which greatly expands their clinical application [8][9][10]. AuNPs have also good safety-profile [11].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Anti-Tumor potential and safety of application of Glutathione stabilized Gold Nanoparticles conjugated with Chemotherapeutics

Steckiewicz¹,

Barcińska²,

Sobczak³

et al. 2020

Int. J. Med. Sci.

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Due to the high toxicity of currently used chemotherapeutics, novel methods of cancer treatment are needed. Gold nanoparticles (AuNPs) seem to be an interesting alternative due to penetration through biological membranes and systemic barriers. AuNPs as carriers of chemotherapeutics allow for reduced concentrations whilst maintaining the expected effect, and thus reducing the costs of therapy and adverse effects. We synthesized AuNPs stabilized with reduced glutathione (GSH) and conjugated with doxorubicin (DOX), gemcitabine (GEM) or cytarabine (CTA). This is the first study in which cytarabine-AuNPs were synthesized and characterized. Transmission electron microscopy (TEM), thermogravimetric analysis (TGA), nuclear magnetic resonance spectroscopy (NMR) and highperformance liquid chromatography (HPLC) were used to chemically characterize obtained nanoparticles. Antitumor activity and safety of application were assessed by MTT assay in in vitro model (human osteosarcoma cells -143B, human osteoblast-hFOB1.19, breast cancer cells -MCF7, breast epithelial cells -MCF10A, pancreatic cancer cells -PANC-1, and pancreatic cells -hTERT-HPNE cells). We have shown that cellular response varies according to the type and concentration of AuNPs. At some concentrations, we were able to show selective cytotoxicity of our AuNPs conjugates only to cancer cell lines. Synthesized nanoparticles were more cytotoxic to tumor cell lines than chemotherapeutics alone.

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A comparative study on the nanoparticles for improved drug delivery systems

Cited by 57 publications

References 101 publications

Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment

Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment

Adsorption of acid red 114 and reactive black 5 in aqueous solutions on dendrimer‐conjugated magnetic nanoparticles

Assessment of Anti-Tumor potential and safety of application of Glutathione stabilized Gold Nanoparticles conjugated with Chemotherapeutics

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