A comparative study on the effects of diet and exercise, metformin and metformin+pioglitazone treatment on NIDDM patients

Abstract

A comparative study on two groups of newly diagnosed nonobese and obese NIDDM patients who were 15 in each group and treated by diet cum exercise and metfromin monotherapy respectively and a third group of 15 obese NIDDM patients whose hyperglycemia was not first controlled by a combination therapy of metformin and sulfonylurea and therefore changed over to a different combination therapy of metformin and ploglitazone, was carried out before and after a period of three months treatment. The mild hyperglycemia in the 1(st) group and the moderate or severe hyperglycemia with accompanied disorders of serum enzymes such as AST, ALT, GGT and the level of HBA(10) observed with 2(nd) and 3(rd) groups of obese NIDDM patients were significantly ameliorated by the respective mode of treatments. Here the efficacies of the three types of treatment are substantiated and further it specifically depicts the success with the choice of combination therapy with metformin and pioglitazone in the third group of obese diabetics.

A Prospective Comparative Study of Effect of Telmisartan Plus Diet and Exercise Versus Telmisartan and Metformin on Metabolic Parameters in Hypertensive Patients With the Metabolic Syndrome

“…The reduction in total cholesterol was more in group B. Mohamed Ali et al found that there is significant reduction in total cholc and Tg concentration, but decrease in LDL-c is not significant which support our study. Similar result was observed by K. T. Augusti et al and Jenly P Nobes et al 16,17,18…”

A study on the hypoglycemic and hypolipidemic effects of an ayurvedic drug Rajanyamalakadi in diabetic patients

“…The drug combinations with Salacia oblonga and such other plants as above could minimize long term diabetic complications also (20). Hence the drug "Rajanyamalakadi" is a three in one combination of several nutraceuticals and their mechanism of action may be through stimulation of insulin secretion (21), antioxidant (22), hypolipidemic, antidiabetic (23,24), hepatoprotective (40) and various such other actions as reported by several workers from time to time for curcuma longa and other plant products. The lowering of blood sugar, serum lipids and amelioration of serum insulin level by the biological actions of the various nutraceuticals in the drug might have protected the liver from various stressful conditions also, eg.…”

Effects of insulin, glimepiride and combination therapy of insulin and metformin on blood sugar and lipid profile of NIDDM patients

“…Even though metformin enhances insulin sensitivity, it is associated with weight loss and does not cause hypoglycemia or an increase in plasma insulin level. The combination of insulin sensitizers such as pioglitazone with metformin may be an attractive therapeutic option for NIDDM patients (6). A number of studies have demonstrated that primary antiglycemic action of metformin results from improved insulin sensitivity, primarily in the liver and secondary in muscle.…”