A comparative study on post-operative pain relief by intrathecal buprenorphine hydrocholoride with control group

Abstract

Background: Surgical trauma is a real and severe tissue damage resulting in surgical pain which is a universal phenomenon. Post-surgical pain experienced by patient is often significantly greater than anticipated by the patient. Recognition that inadequate analgesics adversely affect the patient's cardiovascular, pulmonary and emotional status has spurred development of new and highly effective methods of controlling pain. The benefits of postoperative analgesia are speedy recovery, reduction in physical and mental stress, improvement in pulmonary function (by allowing the patient to cough, breath and move more easily), less stress on cardiac function, decreased incidence of thromboembolic complications. Buprenorphine is a highly lipid soluble narcotic of antagonist agonist type which is 40-50 times more potent than morphine. As per available previous researches, low dose of intrathecal buprenorphine produces prolonged postoperative analgesia with lesser side effects. Methods: The present study was carried out in the department of anaesthesiology, CCM medical college, Durg, Chhattisgarh, India during study period August 2015 to July 2016. The study comprised of 80 patients undergoing surgery of lower abdomen below umbilicus (T10) and lower limbs. Patients of age Group between 20-60 years of age of either sex of ASA group I and II were included in the study. Pre-anesthetic evaluation was done prior to surgery. The patients were randomly divided into 2 groups [group-I (control), group II (Buprenorphine hydrochloride 0.06 mg intrathecally)] of 40 patients each. All the patients were informed about visual analogue scale preoperatively. After the surgical process, observations were recorded. The assessment of results of both groups were done. The results were analysed by unpaired' test and p value. Results: Mean age in both the groups were comparable and statistically insignificant (p>0.05). Mean age in group I was 39.3±1.5 years and group II was 38.5±12.2. In group II, there was male predominance i.e. M: F was 3: 2, whereas in group I sex ratio was equal (M: F was1:1). Mean weight in both groups were comparable and statistically insignificant (p>0.05). In group I mean weight was 49.5±2.5 kg and 45% pts. Were between 40-50 kg weights. In Group II mean weight was 50.9±8.2 kg and 40% patients were between 40-50 kg weights. Patients receiving study drug has significantly rapid onset of sensory block as compared to control Group (p<0.05). Patients of group II had significantly rapid onset of motor block (p<0.05). The mean duration of surgery in group I was 90.8±44.0, and group II 115.0±40.0 min. The mean duration of motor block in Group I was 190.5±57.2 min and group II was 186.5±30.1 min (3.12+ 0.52 hours). Duration of absolute and effective analgesia is significantly higher in Group II. VAS score is significantly lower in group II patients. There was no statistically significant change in systolic blood pressure, diastolic blood pressure and pulse rate attributable to intrathecal buprenorphine. Conclusions: On ...

Effect of different doses of buprenorphine in combination with bupivacaine in the management of postoperative analgesia: A comparative study

“…[ 12 14 16 ] Lower or no bradycardia with lower doses of buprenorphine in our study was supported by studies elsewhere. [ 13 15 17 18 19 ] Our observation of a higher incidence of hypotension in higher doses of buprenorphine (150 μg) compared to lower doses was similar to a study by Mishra and Maharana who reported a significant change in mean arterial pressure with higher doses of buprenorphine. [ 16 ] Other studies also supported our findings on incidences of hypotension with different doses of buprenorphine.…”