A Comparative Study on Aspiration Cytology and Histopathology in Diagnosis of Thyroid Nodule and Its Correlation

Roy, Pijush Kumar; Bandyopadhyay, Shyama; Dubey, Arya Brata; Sengupta, Arjun

doi:10.1007/s12070-019-01681-3

Cited by 8 publications

(12 citation statements)

References 13 publications

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“…Furthermore, correlating the FNAC and histopathological findings in our data set, the diagnostic accuracy was 81.15%. Roy et al 23 reported 91.96% accuracy, Sengupta et al 24 was 98.3%, and Gupta et al 25 was 83% accuracy in their respective studies ( Table 3). 26 Study limitations.…”

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confidence: 88%

“…This is in accordance with the study by Afroze et al, 17 wherein papillary carcinoma was the most common thyroid tumor reported on final histopathology. 21,22 A study by Roy et al 23 showed that the sensitivity of FNAC was 81.5% and specificity of FNAC was 95.3% in their evaluation of thyroid nodules. 23 Sengupta et al, 24 had a sensitivity of 90% and specificity of 100%.…”

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confidence: 99%

“…21,22 A study by Roy et al 23 showed that the sensitivity of FNAC was 81.5% and specificity of FNAC was 95.3% in their evaluation of thyroid nodules. 23 Sengupta et al, 24 had a sensitivity of 90% and specificity of 100%. Gupta et al, 25 in their evaluation of thyroid nodules by FNAC, had a sensitivity of 80% and specificity of 86.6%.…”

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confidence: 99%

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Role of fine-needle aspiration cytology in evaluating thyroid nodules

Bahaj

Alkaff

Melebari

et al. 2020

SMJ

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To evaluate the accuracy and efficacy of fine-needle aspiration cytology (FNAC) in diagnosing thyroid nodules, correlating it with the histopathological findings. Methods: A retrospective evaluation of 314 patients was undertaken at a tertiary referral center of King Abdullah Medical City (KAMC), Makkah, Kingdom of Saudi Arabia, between 2010-2019. Patients who presented with thyroid swellings underwent ultrasonography and FNAC. If indicated, surgery was performed. The FNAC findings were compared to the final histopathological reports. Results: The findings for FNAC from our data set of 314 patients showed a sensitivity value of 79.8%, Original Article specificity of 82.1%, accuracy of 74.8%, positive predictive value of 74.8%, and negative predictive value of 85.9%. Conclusion: Our study showed that FNAC has high sensitivity and specificity in the initial evaluation of patients with thyroid nodules. When guided by ultrasonography, the accuracy can be markedly improved. Molecular markers once widely available can improve the diagnostic power of FNAC to be no less than the histopathologic evaluation of thyroid tissue.

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Role of fine-needle aspiration cytology in evaluating thyroid nodules

Bahaj

Alkaff

Melebari

et al. 2020

SMJ

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“…When we look at the current literature, the highest result is 15.5 and is belonged to Muratlı et al (7). In the literature, the cytologicalhistopathological incompatibility rate is quite high when it comes to follicular lesions (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Fine needle aspiration biopsy is particularly sensitive in detecting papillary, medullary, anaplastic carcinoma, poorly dif-ferentiated follicular and insular carcinoma, while the sensitivity decreases and the false positivity increases in lesions such as adenomatous nodules, FA, well-differentiated FC, HT and noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) which have similar cytological features (7).…”

Section: Discussionmentioning

confidence: 98%

“…Anadolu Klin / Anatol Clin In the literature, FNAB sensitivity ranges from 57-99%, and specificity ranges from 60-99 (2,3,(7)(8)(9)(10)(11)(12)(13)(14). When calculating the sensitivity and sensitivity, what needs to be done is to divide the cytological and histopathological diagnoses into 2 groups as malignant and benign.…”

Section: Discussionmentioning

confidence: 99%

Tiroid Nodüllerinin Değerlendirilmesinde Bethesda Sistemi ve İnce İğne Aspirasyon Biopsisinin Yeri

Akgün

Aslan

2021

Anadolu Kliniği Tıp Bilimleri Dergisi

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In this study, the role of fine needle aspiration biopsy (FNAB) evaluated with the Bethesda System in the diagnosis of thyroid nodules was investigated. Materials and Methods: Total 2284 FNAB materials of 1846 patients were performed in the Pathology Department of Kutahya Health Sciences University, Evliya Celebi Traning and Research Hospital between 2016 and 2019 and reported according to the Bethesda category. Among these cases, diagnostic sensitivity, specificity, accuracy, positive and negative predictive values of FNAB were calculated by making cytohistopathological comparison in 328 cases who underwent total thyroidectomy. Results: In the study, 1538 of the 1846 patients included were female (83.31%) and 308 (16.68%) were male. The average age was 49.92 years (Age range 19-87). The final cytological diagnoses of 2284 FNABs were as follows: 287 (12.57%) nondiagnostic or unsatisfactory, 1517 (66.42%) benign cytology, 316 (13.83%) atypia of undetermined significance/follicular lesion of undetermined significance, 63 (2.75%) follicular neoplasm or suspicious for a follicular neoplasm, 59 (2.59%) suspicious for malignancy and 42 (1.84%) malignant cytology. Histologically, 245 (74.70%) of the 328 cases were benign, while 83 (25.30%) were malignant. The number of true negative cases was 216 (65.85%), the number of true positive cases was 62 (19.90%), the number of false positive cases was 29 (8.84%) and the number of false negative cases was 21 (6.40%). In this case, diagnostic sensitivity, specificity, accuracy rates, positive and negative predictive values were 74.7%, 88.16%, 84.76%, 68.13% and 91.14%, respectively. Conclusion:In our study, it was observed that the sensitivity, specificity, accuracy rates, positive and negative predictive values of thyroid FNABs were compatible with the literature. We think that as the experience of the clinician and cytopathologist increases, false negative and positive results will decrease and at the same time, the confidence in thyroid FNABs will increase even more with the participation of some recent molecular methods (BRAF, RET/PTC, PAX8/PPARG and RAS) applied to FNABs.

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Diagnostic Accuracy of Fine-Needle Biopsy in the Detection of Thyroid Malignancy

et al. 2022

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ImportanceFine-needle biopsy (FNB) became a critical part of thyroid nodule evaluation in the 1970s. It is not clear how diagnostic accuracy of FNB has changed over time.ObjectiveTo conduct a systematic review and meta-analysis estimating the accuracy of thyroid FNB for diagnosis of malignancy in adults with a newly diagnosed thyroid nodule and to characterize changes in accuracy over time.Data SourcesPubMed, SCOPUS, and Cochrane Central Register of Controlled Trials were searched from 1975 to 2020 using search terms related to FNB accuracy in the thyroid.Study SelectionEnglish-language reports of cohort studies or randomized trials of adult patients undergoing thyroid FNB with sample size of 20 or greater and using a reference standard of surgical histopathology or clinical follow-up were included. Articles that examined only patients with known thyroid disease or focused on accuracy of novel adjuncts, such as molecular tests, were excluded. Two investigators screened each article and resolved conflicts by consensus. A total of 36 of 1023 studies met selection criteria.Data Extraction and SynthesisThe MOOSE guidelines were used for data abstraction and assessing data quality and validity. Two investigators abstracted data using a standard form. Studies were grouped into epochs by median data collection year (1975 to 1990, 1990 to 2000, 2000 to 2010, and 2010 to 2020). Data were pooled using a bivariate mixed-effects model.Main Outcomes and MeasuresThe primary outcome was accuracy of FNB for diagnosis of malignancy. Accuracy was hypothesized to increase in later time periods, a hypothesis formulated prior to data collection.ResultsOf 16 597 included patients, 12 974 (79.2%) were female, and the mean (SD) age was 47.3 (12.9) years. The sensitivity of FNB was 85.6% (95% CI, 79.9-89.5), the specificity was 71.4% (95% CI, 61.1-79.8), the positive likelihood ratio was 3.0 (95% CI, 2.3-4.1), and the negative likelihood ratio was 0.2 (95% CI, 0.2-0.3). The area under the receiver operating characteristic curve was 86.1%. Epoch was not significantly associated with accuracy. None of the available covariates could explain observed heterogeneity.Conclusions and RelevanceAccuracy of thyroid FNB has not significantly changed over time. Important developments in technique, preparation, and interpretation may have occurred too heterogeneously to capture a consistent uptrend over time. FNB remains a reliable test for thyroid cancer diagnosis.

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A Comparative Study on Aspiration Cytology and Histopathology in Diagnosis of Thyroid Nodule and Its Correlation

Cited by 8 publications

References 13 publications

Role of fine-needle aspiration cytology in evaluating thyroid nodules

Role of fine-needle aspiration cytology in evaluating thyroid nodules

Tiroid Nodüllerinin Değerlendirilmesinde Bethesda Sistemi ve İnce İğne Aspirasyon Biopsisinin Yeri

Diagnostic Accuracy of Fine-Needle Biopsy in the Detection of Thyroid Malignancy

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