A comparative study of vestibular improvement and gastrointestinal effect of betahistine and gastrodin in mice

Zhang, Yang-Xun; Wang, Hong-Xiao; Li, Qian-Xiao; Chen, Ao-Xue; Wang, Xiaoxia; Zhou, Shuang; Xie, Shutao; Li, Hongzhao; Wang, Jianjun; Zhang, Qipeng; Zhang, Xiaoyang; Zhu, Jing-Ning

doi:10.1016/j.biopha.2022.113344

Cited by 7 publications

(4 citation statements)

References 63 publications

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“…We then aimed to showcase our insertion reaction on late-stage functionalization of bioactive molecules. Four amino acids together with two clinical drugs [18][19] were examined. These compounds gave NÀ H insertion products (3 ac-3 ah) with up to 91% yield.…”

Section: Resultsmentioning

confidence: 99%

Anhydrous Carbene Insertion Reactions: A Synthetic Platform for DNA‐Encoded Library

Su,

Shi,

Zhang

et al. 2023

Adv Synth Catal

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An operationally simple anhydrous carbene insertion reaction to construct DNA‐encoded libraries (DEL) is reported. The developed reaction employs visible light photolysis of diazo compounds and Reversible Adsorption to Solid Support (RASS) strategy. From readily available amines, alcohols, phenols, and carboxylic acids, a variety of high‐value molecules, including useful unnatural amino acids, ethers, and esters, promising clinical drug derivatives, and bioactive molecules have been constructed.

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Section: Resultsmentioning

confidence: 99%

Anhydrous Carbene Insertion Reactions: A Synthetic Platform for DNA‐Encoded Library

Su,

Shi,

Zhang

et al. 2023

Adv Synth Catal

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“…Furthermore, few adverse reactions of gastrodin have been reported and gastrodin takes effects in a wide range of concentrations. Recently, it is reported that the combination of gastrodin and betahistine improves betahistine-induced gastrointestinal dysfunction via regulating the secretion of gastric acid ( Zhang et al, 2022b ). Zheng et al believed that gastric mucosal injury induced by borneol could be mitigated when gastrodin was combined with borneol ( Cai et al, 2014 ).…”

Section: Discussionmentioning

confidence: 99%

“…Not only that, it was also demonstrated that gastrodin possesses diverse pharmacological properties including restoration of lysosomal function and autophagy ( Tao et al, 2021 ), inhibition of nuclear factor kappa-B (NF-κB) and mitogen-activated protein kinase (MAPKs), downregulation of inducible nitric oxide synthase (iNOS) and COX-2, and activation of phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway ( Yang et al, 2013 ). In addition, it is reported that gastrodin alleviates betahistine-induced gastrointestinal dysfunction by reducing gastric acid secretion ( Zhang et al, 2022b ). Meanwhile, it is shown that gastrodin mitigates gastric mucosal damage caused by borneol ( Cai et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Aspirin in combination with gastrodin protects cardiac function and mitigates gastric mucosal injury in response to myocardial ischemia/reperfusion

et al. 2022

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Myocardial ischemia/reperfusion (I/R) injury after percutaneous coronary intervention (PCI) is common in acute myocardial infarction. Aspirin is commonly prescribed as anti-thrombotic therapy with coronary heart disease (CHD). However, long-term use of aspirin causes severe gastric mucosal damage. Gastrodin is a Chinese natural medicine with anti-inflammatory and anti-oxidative properties. In this study, we investigated the effects of combined therapy with aspirin and gastrodin on the myocardial and gastric mucosal injury in response to myocardial I/R injury and underlying mechanisms using the Sprague-Dawley (SD) rat model. Our results demonstrated that myocardial I/R caused significant cardiac dysfunction and gastric mucosal damage. Administration of aspirin led to significantly reduce myocardial infarction size and myocardial enzyme release, as well as significantly improved cardiac function through exerting anti-inflammatory effects. However, aspirin exacerbated gastric mucosal damage by increasing the levels of inflammatory mediators and endothelin (ET) while reducing prostaglandin E2 (PGE2) levels. The combined treatment with aspirin and gastrodin not only significantly protected gastric mucosa by normalizing the expression levels of the inflammatory factors, ET and PGE2, but also significantly reduced myocardial infarction size and improved cardiac function by inhibiting inflammation in response to I/R. The combination therapy also dramatically down-regulated the levels of pyroptosis-related proteins in the myocardium and gastric mucosa. The combination therapy showed obviously reduced level of thromboxane B2 (TXB2), which was simultaneously accompanied with increased levels of the tissue plasminogen activator (t-PA). This suggested that gastrodin did not inhibit the anti-thrombotic function of aspirin. Accordingly, aspirin in combination with gasrtodin protected the structural and functional integrity of the heart and stomach by suppressing pyroptosis and inflammation. Therefore, combination of aspirin and gastrodin is a promising treatment for cardiac dysfunction and gastric mucosa injury after myocardial I/R.

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“…Rhizoma Gastrodiae possesses anti-aging, sedative, hypnotic, anti-inflammatory and anti-oxidant properties. Research has found that it exerts a good effect on cerebral diseases, especially on AD [ 8 ]. Gastrodin (GAS), an active component of Rhizoma Gastrodiae, has an inhibitory activity against acetylcholinesterase, which can increase the cerebral blood flow, enhance the brain function, reduce the cerebrovascular resistance and increase the cerebrovascular blood transport; substantial studies have found that GAS has a certain therapeutic effect on AD [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Gastrodin ameliorates neuroinflammation in Alzheimer’s disease mice by inhibiting NF-κB signaling activation via PPARγ stimulation

Yin,

Liu,

Bie

2024

Aging

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Aim: We investigated the effects and targets of gastrodin (GAS) for improving cognitive ability in Alzheimer's disease (AD). Methods: The targets and mechanisms of GAS were analyzed by network pharmacology. Morris water and eight-arm radial mazes were used to detect the behaviors of 7-months-old APP/PS1 mice. The levels of IBA-1 and PPARγ were examined by histochemical staining, nerve cells were detected by Nissl staining, inflammatory cytokines were measured by ELISA, and protein expressions were monitored by Western blotting. The neurobehavioral effects of GAS on mice were detected after siRNA silencing of PPARγ. Microglia were cultured in vitro and Aβ1-42 was used to simulate the pathology of AD. After treatment with GAS, the levels of inflammatory cytokines and proteins were assayed. Results: Network pharmacological analysis revealed that PPARγ was the action target of GAS. By stimulating PPARγ, GAS inhibited NF-κB signaling activation and decreased neuroinflammation and microglial activation, thereby ameliorating the cognitive ability of AD mice. After silencing PPARγ, GAS could not further improve such cognitive ability. Cellular-level results demonstrated that GAS inhibited microglial injury, reduced tissue inflammation, and activated PPARγ. Conclusions: GAS can regulate microglia-mediated inflammatory response by stimulating PPARγ and inhibiting NF-κB activation, representing a mechanism whereby it improves the cognitive behavior of AD.

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A comparative study of vestibular improvement and gastrointestinal effect of betahistine and gastrodin in mice

Cited by 7 publications

References 63 publications

Anhydrous Carbene Insertion Reactions: A Synthetic Platform for DNA‐Encoded Library

Anhydrous Carbene Insertion Reactions: A Synthetic Platform for DNA‐Encoded Library

Aspirin in combination with gastrodin protects cardiac function and mitigates gastric mucosal injury in response to myocardial ischemia/reperfusion

Gastrodin ameliorates neuroinflammation in Alzheimer’s disease mice by inhibiting NF-κB signaling activation via PPARγ stimulation

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