A Comparative Study of Varying Protein Intake in Low Birthweight Infant Feeding

Abstract

Svenningsen, N.W., Lindroth, M. and Lindquist, B. (Department of Paediatrics, University of Lund, Sweden). A comparative study of varying protein intake in low birthweight infant feeding. Acta Paediatr Scand. Suppl. 296: 28, 1982. — In a prospective longitudinal study of 48 very low birthweight and preterm infants with mean birthweight 1 385±343 and gestational age 30.8±2.9 w an assessment was made of the impact of varying the protein intake in the postnatal period from the 3rd to 7th week of life. The infants were randomly allocated to one of three dietary groups with isocaloric energy supply but different protein content—i.e. human milk (1.6 g/100 kcal), formula 1 (2.3 g/100 kcal) and formula 2 (3.0 g/100 kcal). In the human milk group 12 of 18 infants were fed their own mother's breastmilk. During the study period the mean weight gain was slightly higher in the infants fed formula 1 and 2. There were no group differences in S‐albumin whereas B‐urea‐N and B‐base deficit were significantly increased in the formula fed infants in comparison to infants fed human milk. After the study period until around 15 weeks of age the slope in weight gain remained slightly higher for formula fed infants. However, the gain in body length and head circumference was equal in all three groups. After around 8 months of age there was no difference in any growth parameter. Neurodevelopmental examinations showed no group differences during the follow‐up period to 2 years of age.

Nutrition and neurodevelopmental outcomes in preterm infants: a systematic review

“…Two EN studies that investigated increasing protein showed contrasting results , and Svenningsen et al. reported no group differences in neurodevelopmental outcomes at two years of age, whereas Basini et al.…”

“…Two EN studies that investigated increasing protein showed contrasting results , and Svenningsen et al. reported no group differences in neurodevelopmental outcomes at two years of age, whereas Basini et al. found that infants receiving additional protein performed better in the items of the GMDS at three months CGA (95.5 vs 109.8, p = 0.04).…”

“…Interventions varied between studies; five of the six PN trials investigated early delivery and increased content of protein , the remaining PN trial investigated increases in both micro‐ and macronutrients . Four of the seven EN studies investigated multinutrient supplementation to either maternal or donor breast milk , two studies investigated protein supplementation to breast milk , and one study compared protein enriched formula to standard formula . In addition to supplementation, Lucas et al.…”

Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review

“…The investigators did not find any significant difference in the incidence of NEC. When the data were combined with those of the previously included trials, the Lucas (1990) 3 Sealed envelopes Yes No Yes Can't tell Svenningsen (1982) 10 Not stated Can't tell No Yes Can't tell Tyson (1983) 11 Sealed envelopes Yes No Yes Can't tell meta-analysis did not find any significant difference in the incidence of NEC: RR 0.68 (95% CI 0.34 to 1.37); RD −0.02 (95% CI −0.05 to 0.01). However, we found a borderline significant difference in the incidence of confirmed NEC: RR 0.30 (95% CI 0.11 to 0.87); RD −0.03 (95% CI −0.06 to 0.00).…”

Protective effects of different doses of human milk on neonatal necrotizing enterocolitis

“…On this basis, fixed effect model was utilized for the incorporation of effects. In total, 6 studies [ 17 – 22 ] compared the incidence of NEC between infants received exclusive human milk or exclusive formula. Meta-analysis showed that compared with the exclusive formula, the incidence of NEC in the infants fed by exclusive human milk was significantly lower (RR = 0.24, 95% CI: 0.08–0.77, P < .05).…”