A Comparative Study of Typhidot and Widal Test in the Diagnosis of Typhoid Fever

T.P, Balakrishna; Sumathi, S; Anuradha, K.; Venkatesh, D; Krishna, Sushma

doi:10.14260/jemds/754

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Desain penelitian adalah rencana penelitian yang berguna sebagai pedoman dalam menjalankan proses penelitian. Tujuan dari desain penelitian yaitu agar peneliti memiliki pegangan yang jelas dan terstruktur selama menjalankan penelitian [5,6,7]. Desain penelitian yang digunakan dalam penelitian ini adalah Studi Perbandingan (Comparative Study), yaitu membandingkan faktor-faktor dari dua sampel yang mempengaruhi dalam penelitian [8].…”

Section: Metodologi Penelitianunclassified

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Gambaran Hasil Pemeriksaan Widal Menggunakan Serum Dan Plasma Edta Pada Suspek Demam Tifoid Di Rumah Sakit Umum Daha Husada Kota Kediri

Sabban¹,

Magdalena²,

Wardani³

et al. 2023

JUKEKE

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Typhoid fever is a systemic infection of the digestive system caused by the bacteria Salmonella typhi and Salmonella paratyphi. This disease is still a major health problem in the world. One of the tests for typhoid fever is the slide method widal test which measures antibodies to Salmonella typhi antigens. The most frequently used specimen is serum, but some hospitals use plasma as a substitute for serum. The purpose of this study was to compare the results of the widal examination using EDTA serum and plasma in suspected typhoid fever at Daha Husada General Hospital, Kediri City. The research design used a comparative study with a total population of 54 people. The study sample consisted of 15 patients using the quota sampling method. Analysis of research data used the Lilliefors test to test data normality and the Wilcoxon test to determine whether there was a comparison of the results of the widal examination using EDTA serum and plasma. The results showed that there were differences in the results of the widal examination using EDTA serum and plasma. The conclusion of the study was that there was a comparison of the results of the widal examination using EDTA serum and plasma in suspected typhoid fever at Daha Husada General Hospital, Kediri City.

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Section: Metodologi Penelitianunclassified

“…Berdasarkan hasil penelitian didapatkan hasil yang bervariasi dimulai dari hasil negatif (ditandai tidak munculnya aglutinasi pada pemeriksaan titer 1/80), 1/80, 1/160 dan 1/320. Interpretasi hasil pemeriksaan widal dianggap positif jika mempunyai arti klinis sebagai berikut [6,8,12]:…”

Section: Syarat Sampel Yang Baik[9]unclassified

Gambaran Hasil Pemeriksaan Widal Menggunakan Serum Dan Plasma Edta Pada Suspek Demam Tifoid Di Rumah Sakit Umum Daha Husada Kota Kediri

Sabban¹,

Magdalena²,

Wardani³

et al. 2023

JUKEKE

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Characteristic Features of Culture Positive Enteric Fever in Pediatric Teaching Hospital in Sulaimani Governorate

Tyib¹,

Fakhir²

2017

JSMC

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Background Typhoid fever is still common disease in our country, and at the present time we are facing resistant cases to usual antibiotics. Objectives This study has been carried out to identify the clinical and laboratory characteristics of these microorganisms. Materials and Methods This is a prospective study done from October 2008 to October 2009, in Sulaimani Pediatric Teaching hospital. Blood cultures were taken from patients suspected of having Typhoid fever ,only patients with positive cultures were included in this study. Data regarding age, sex, residency, clinical presentation, duration of fever at presentation, response to treatment and antibiotic susceptibility were all analyzed by SPSS version 16.0. Results Ninety six patients whom with culture proved cases of Enteric fever, 55 males and 41 females. The age of the patients were from 1 month -14 years with an average of 6.8 years. The duration of fever before attendance to medical care was (2-19) days with a mean of 7 days. Mean days needed for subsidence of fever was 5 days ranging from 2-10 days. Mean duration of admission was about 8.5 days, while mean duration of treatment was 14 days. Headache was the most common symptom (67.7%) followed by abdominal pain in 56.6%, diarrhea in 31.2%, While the symptoms least encountered were confusion 5.2% and constipation 1%. Splenomeagly was the commonest sign (56.2%) followed by hepatomegaly (35.4%) and neck stiffness was positive in (3.1%)of the patients whom had normal CSF examination. The mean WBC count was 5.378 109/l, with 61% of the patients having neutrophilia and 20.7% having lymphocytosis and 18.3% having equal distribution. Most of the isolates were sensitive to amikacin 87%, followed by doxycycline 85.7%, ciprofloxacin 81.5%, azithromycin 60%. Cefotaxime and ceftriaxone had sensitivities of about 52-54%, while there was 75% resistance to chloramphenicol and nearly 99% resistance to ampicillin. All cases were culture positive; 99% for Salmonella typhi and only 1% grew Salmonella para typhi A and B. The incidence of complications was about 10.4%,GIT bleeding being the most common 4.2% followed by renal failure and hepatitis 2% and ataxia 1.1%. Mortality rate was (1.1%). Conclusion Typhoid fever has different presentations according to the locality and also may change its presentation in form of outbreaks in a specific locality. The disease was multidrug resistant, this may be due to previous misuse of antibiotics.

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Systematic Review of Rapid Typhoid Diagnostic Kits

Haritsa,

Sangeetha

2024

Journal of the Scientific Society

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Typhoid fever is a bacterial infection that can be fatal and a major concern globally. Due to the infection’s high morbidity and fatality rates, there is an urgent need for precise and quick diagnostic tests to help with disease management and prevention. The purpose of the current review is to evaluate the specificity and sensitivity of the currently commercially available typhoid fever rapid diagnostic kits (RDTs). Publicly available English databases, such as PubMed and Google Scholar, were used to screen the research papers. We mined a total of 371 research documents, of which 18 articles were selected based on the inclusion and exclusion criteria. Studies from 10 different developing countries evaluated the diagnostic performance of Typhidot, Typhidot-M, and Tubex. The average sensitivity and specificity were approximately 80%–90% and 65%–78% for Typhidot, 85%–94% and 77%–89% for Typhidot-M, and 94.7% and 80.4% for Tubex. The sensitivity and specificity of these diagnostics varied with the geographical location. In comparison to the widely used Widal test, the observed performance cannot support the exclusive use of a particular RDT. Hence, there is a need to develop affordable, antigen-based RDTs.

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A Comparative Study of Typhidot and Widal Test in the Diagnosis of Typhoid Fever

Cited by 3 publications

References 12 publications

Gambaran Hasil Pemeriksaan Widal Menggunakan Serum Dan Plasma Edta Pada Suspek Demam Tifoid Di Rumah Sakit Umum Daha Husada Kota Kediri

Gambaran Hasil Pemeriksaan Widal Menggunakan Serum Dan Plasma Edta Pada Suspek Demam Tifoid Di Rumah Sakit Umum Daha Husada Kota Kediri

Characteristic Features of Culture Positive Enteric Fever in Pediatric Teaching Hospital in Sulaimani Governorate

Systematic Review of Rapid Typhoid Diagnostic Kits

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