A Comparative Study of Two Different Doses of Intravenous Ondansetron for Prevention of Post-spinal Anesthesia Shivering in Inguinal Hernia Repair Surgery

Abstract

Background: Shivering is one of the most commonly encountered problems after both general and regional anesthesia and its incidence about 40% to 50% of the patients whom undergoing surgical operation under spinal anesthesia. The aim of this work was to compare two different clinically relevant doses of ondansetron (4mg vs 8mg) in prevention of postspinal anesthesia in inguinal herniorrhaphy. Patients and Methods: A comprehensive sample included elective unilateral inguinal hernia in Zagazig University hospitals during period of six months from November 2018 to April 2019 (10-11 cases / month) sample will be 63 cases randomly allocated into 3 groups; group A (ondansetron 4mg IV), group B (ondansetron 8mg IV) and group C (control group). Results: Each dose of ondansetron 4 mg or 8 mg have the ability to decrease the incidence of postspinal anesthesia with no significant differences between the two doses. There were no significant difference regarding side effects of the two doses of ondansetron in prevention of post spinal shivering. Conclusion: we concluded that both doses of intravenous ondansetron 4mg and 8mg are efficient and safe in reducing the incidence and severity of shivering during spinal anesthesia.

Comparison of Intravenous Granisetron and Ondansetron on Hemodynamics and Sensory Motor Block After Spinal Anaesthesia With Hyperbaric Bupivacaine in Patients Undergoing Elective Surgery: A Randomized Double-Blind Study

“…Ondansetron is a potent, selective, competitive antagonist at 5-HT3 receptors, which have a role in the attenuation of spinal anaesthesia-induced episodes of nausea, vomiting, and hypotension [ 7 ]. However lower doses of ondansetron were preferred as the risk of prolonged Q-T interval was more with a higher dose, while the efficacy remains constant [ 8 ]. Granisetron is a highly selective 5-HT3 receptor antagonist and effectively attenuates spinal anaesthesia-induced hypotension [ 9 ].…”