A comparative study of trans- and cis-isomers of a bone-seeking agent, DO2A2P

Hao, Guiyang; Liu, Wei; Hassan, Gedaa; Öz, Orhan K.; Sun, Xiankai

doi:10.1016/j.bmcl.2014.12.016

Cited by 5 publications

(2 citation statements)

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“…6) have been studied with respect to their comparative biological behaviour. 65 Both isomers were radiolabelled with 177 Lu, for potential applications such as radiotherapy and/or imaging of bone diseases. Biological assays, such as hydroxyapatite binding, in vitro stability, and in vivo distribution, showed the pair had almost identical biological properties.…”

Section: Macrocyclic Ligand Derivativesmentioning

confidence: 99%

Chelating agents for radiolanthanides: Applications to imaging and therapy

Amoroso

Fallis

Pope

2017

Coordination Chemistry Reviews

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Section: Macrocyclic Ligand Derivativesmentioning

confidence: 99%

Chelating agents for radiolanthanides: Applications to imaging and therapy

Amoroso

Fallis

Pope

2017

Coordination Chemistry Reviews

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“…However, previous studies mainly focused on the residue of IZM at the racemic level; no studies focused on the residue behavior of IZM at the isomer level. Different isomers of compounds have similar chemical properties, but they might show different biological behaviors in living environments . Studies have shown that the absorption, accumulation, and degradation processes of different isomers in organisms and the environment are often different. , Thus, studying the behavior of pesticides at the isomer level can better elucidate their environmental risk.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of the Residues of Isopyrazam Isomers and Their Metabolites in Soil and Tomatoes by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry

Fang

Liu

Zhang

et al. 2021

J. Agric. Food Chem.

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An effective and sensitive method for the determination of isopyrazam (IZM) isomers (syn-IZM and anti-IZM) and their metabolites (syn545364 and syn545449) in tomato and soil by ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed in the present study. The method showed excellent linearities (R 2 = 0.999) at 0.005–5 mg/L. The recoveries were 92.0–107%, and the relative standard deviation (RSD) values were lower than 9.40% in tomato and soil matrices at 0.01, 0.1, and 10 mg/kg. The limits of detection (LODs) of the four compounds ranged from 6.88 × 10–5 to 2.70 × 10–4 mg/kg, while the limits of quantification (LOQs) ranged from 2.20 × 10–4 to 9.20 × 10–4 mg/kg. The storage stability test results showed that syn-IZM, anti-IZM, syn545449, and syn545364 were stable in tomato at −20 °C within 36 weeks, and the maximum degradation rates were 16.0, 12.0, 7.10, and 12.0%, respectively. The field dissipation test results showed that the half-lives of syn-IZM in tomato and soil were 2.60–10.2 and 13.6–33.0 days, respectively, while the half-lives of anti-IZM in soil were 21.7–46.2 days, and no residues of anti-IZM were detected in tomato. The terminal residue test results showed that the residue of syn-IZM and anti-IZM in tomato ranged from <0.0100–0.490 to <0.0100–0.0850 mg/kg. The present results showed that anti-IZM degraded faster than syn-IZM in tomato and soil, and had a lower residue level in tomato.

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Structure and Magnetism of Seven‐Coordinate Fe^III, Fe^II, Co^II and Ni^II Complexes Containing a Heptadentate 15‐Membered Pyridine‐Based Macrocyclic Ligand

et al. 2018

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A heptadentate macrocyclic ligand, H 2 L (3,12,18triaza-6,9-dioxabicyclo[12.3.1]octadeca-1,14,16-triene-3,12-diacetic acid) with two acetate pendant arms, and its complexes [Fe III L]ClO 4 (1), [Fe II L]·H 2 O (2), [Co II L]·H 2 O (3), and [Ni II L]·H 2 O (4) were synthesized. The complexes possess an axially compressed pentagonal bipyramidal geometry with the coordination numbers of 7 for 2 and 3, and 6 + 1 for 4. The magnetic susceptibility measurements revealed magnetic anisotropy for compounds 1-4 expressed by axial zero-field splitting (ZFS) parameters (D = [a] [{Ni(H 2 dabph)} 3 {W(CN) 8 } 2 ] (below the blocking temperature T N = 3.6 K, τ 0 = 1.6 × 10 -9 s, U eff = 30 K), [22] and for many different Co II complexes. [10,18,23,24] Furthermore, the magnetic anisotropy has been tuned by playing with donor/acceptor properties of two axial coligands, as was shown on series of Co II complexes, e.g. [Co(tdmmb)(X) 2 ] 2+/0 , [20] where X = H 2 O, CN -, NCS -, SPh -, with the more pronounced anisotropy for the complex with SPh -(D = 39.7 cm -1 ), or [Co(15-pyN 3 O 2 )X 2 ], [23] where X = Cl -, Brand Iwith the highest D = 41 cm -1 for the dibromido complex, and also on Mn II complexes [Mn(15-pyN 3 O 2 )X], [25] where X = Br -, I -, N 3 -, NCS -, with a small influence of axial coligands on the magnetic anisotropy (|D| < 0.7 cm -1 ).The recent results suggest that also seven-coordinate lanthanide complexes with pentagonal bipyramidal geometry show remarkable properties, [26] concretely a very high magnetization reversal barrier was found for [Dy(OPCy 3 )(H 2 O) 5 ] 3+ , [27] [Dy(tBuPO(NHiPr) 2 ) 2 (H 2 O) 5 ] 3+ , [28] [Dy(bbpen)Cl], and [Dy-(bbpen)Br] [29] with U eff = 543, 735, 708, and 1025 K, respectively.A different approach how to tune desired structural and magnetic properties of complexes can be associated with modification of the original pentadentate macrocycle, e.g. 15-pyN 3 O 2 , with two pendant arms containing different functional groups providing heptadentate ligand and seven-coordinate complexes. Variations in the functional groups of the pendant arms can provide fine tuning of the ligand field for the complexed metal ions. Such approach was successfully employed in our previous study concerning the seven-coordinate Mn II , Fe II , Co II , and Ni II complexes of py 2 -15-pyN 3 O 2 (Figure 1) with two 2-pyridylmethyl pendant arms. [30] Magnetic measurements revealed noticeable values of magnetic anisotropy for [Fe(py 2 -15-pyN 3 O 2 )](ClO 4 ) 2 (D = -7.4 cm -1 ), [Co(py 2 -15-pyN 3 O 2 )](ClO 4 ) 2 (D = 34 cm -1 ), and [Ni(py 2 -15-pyN 3 O 2 )](ClO 4 ) 2 (D = -12.8 cm -1 , E/D = 0.136). Moreover, the slow relaxation of the magnetization was observed [τ 0 = 9.90 × 10 -10 s, U eff = 24.3 K (16.9 cm -1 )] for [Co(py 2 -15-pyN 3 O 2 )](ClO 4 ) 2 . [30] Eur.

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A comparative study of trans- and cis-isomers of a bone-seeking agent, DO2A2P

Cited by 5 publications

References 9 publications

Chelating agents for radiolanthanides: Applications to imaging and therapy

Chelating agents for radiolanthanides: Applications to imaging and therapy

Simultaneous Determination of the Residues of Isopyrazam Isomers and Their Metabolites in Soil and Tomatoes by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry

Structure and Magnetism of Seven‐Coordinate Fe^III, Fe^II, Co^II and Ni^II Complexes Containing a Heptadentate 15‐Membered Pyridine‐Based Macrocyclic Ligand

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A comparative study of trans- and cis-isomers of a bone-seeking agent, DO2A2P

Cited by 5 publications

References 9 publications

Chelating agents for radiolanthanides: Applications to imaging and therapy

Chelating agents for radiolanthanides: Applications to imaging and therapy

Simultaneous Determination of the Residues of Isopyrazam Isomers and Their Metabolites in Soil and Tomatoes by Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry

Structure and Magnetism of Seven‐Coordinate FeIII, FeII, CoII and NiII Complexes Containing a Heptadentate 15‐Membered Pyridine‐Based Macrocyclic Ligand

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Structure and Magnetism of Seven‐Coordinate Fe^III, Fe^II, Co^II and Ni^II Complexes Containing a Heptadentate 15‐Membered Pyridine‐Based Macrocyclic Ligand