A comparative study of tissue glue and vicryl suture for conjunctival and scleral closure in conventional 20-gauge vitrectomy

Abstract

Aim To describe the use of tissue glue to close scleral and conjunctival wounds, and to compare the clinical outcomes using tissue glue and vicryl suture for closing these areas in conventional 20-gauge (G) vitrectomy. Methods Thirty eyes of 30 patients were included in this study. The indications for vitreoretinal surgery were diabetic vitreous haemorrhage with severe vitreoretinal traction in 10 eyes, retinal detachment and proliferative vitreoretinopathy in 14 eyes, and vitreous opacity in 6 eyes. Tissue glue (Tisseel, Baxter AG Industries, Vienna, Austria) was used to attach scleral and conjunctival wounds in 15 eyes and vicryl sutures in 15 eyes. The patients were allotted into two subgroups as tissue glue group (TG) and vicryl suture group (VG). The sclerotomy sites were evaluated with ultrasound biomicroscopy (UBM) postoperatively in TG. Follow-up period was 2 months. The groups were statistically compared for ocular signs and symptoms by Mann-Whitney U-test. Results No scleral wound leakage and conjunctival reattachment were observed at the end of the surgical procedure and during the follow-up period. No adverse effects were seen in TG. Abnormal fibrous ingrowth was not detected at the sclerotomy sites by means of UBM in TG. Patient comfort was significantly higher in TG than VG (Po0.05).Conclusions Tissue glue has no adverse effects on ocular tissue and can be used as a substitute for suture materials, and the use of tissue glue decreases patient symptoms during the postoperative period after 20-G vitrectomy.Tissue glue can enable to perform sutureless surgery in the conventional 20-G vitrectomy.

Comparison of Fibrin Glue and Sutures for Conjunctival Wound Closure in Strabismus Surgery

“…Third, the coagulation time of fibrin glue can be controlled during surgery by controlling the thrombin concentration, and its rapid coagulation could shorten the operation time. Recently fibrin glue has been studied for many ophthalmic uses [2-11], including scleral closure in cataract surgery and pars plana vitrectomy [26,27]. …”

Advantages of nanofibrous membranes for culturing of primary RPE cells compared to commercial scaffolds

“…Na + /K + ATPase participates in the turnover of cations important for the polarization/depolarization of the apical part of the RPE membrane upon receiving photons by photoreceptors (Marmorstein et al 1998(Marmorstein et al , 2000Marmorstein 2001). The third ion exchanger, MCT1, is responsible for the symport of H + -lactate and water and thus has an important role in maintaining intracellular pH and water homeostasis (Batman et al 2008). Elevated levels of BEST1, Na + /K + ATPase in our cultured RPE cells determined by gene and protein analysis (WB) demonstrated a highly polarized state of our epithelial monolayer.…”

“…The third ion exchanger, MCT1, is responsible for the symport of H + ‐lactate and water and thus has an important role in maintaining intracellular pH and water homeostasis (Batman et al. 2008). Elevated levels of BEST1, Na + /K + ATPase in our cultured RPE cells determined by gene and protein analysis (WB) demonstrated a highly polarized state of our epithelial monolayer.…”

Suncon medical adhesive is a suitable alternative to fibrin glue in the 23G minimally invasive vitrectomy

“…Sutureless surgery avoids irritation of ocular tissues and is, therefore, the most popular method to prevent IOP. To close the incision of the sclera and conjunctiva, fibrin glue was used, first in a 20G vitrectomy (1), and subsequently in 23G and 25G vitrectomies (2). No incision leakage, adverse effects, or low IOP were observed during the postoperative follow-up.…”