A Comparative Study of the Effect of Ultrasound and Electrostimulation on Wound Healing in Rats

Taşkan, Işik; Özyazgan, İrfan; Tercan, Mustafa; Kardas, Hakan; Balkanlı, Süleyman; Saraymen, Recep; Zorlu, Ümran; Özügül, Yavuz

doi:10.1097/00006534-199709001-00020

Cited by 58 publications

(65 citation statements)

References 20 publications

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“…In the motor ES group, we applied monophasic pulsed current with an intensity enough to elicit a visible minimum contraction (about 2.5-3.0 mA), pulse duration 300 s, frequency 100 Hz, for 1 h/day, every other day, for 3 or 7 days. These ES parameters have been used in many other studies [15,[17][18][19]. The ES device used in this study was the BTL-5000 series (BTL Industries Ltd; Hertfordshire, United Kingdom).…”

Section: Wounding and Treatment Protocolmentioning

confidence: 99%

Effect of sensory and motor electrical stimulation in vascular endothelial growth factor expression of muscle and skin in full-thickness wound

Asadi¹,

Torkaman²,

Hedayati³

2011

JRRD

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Abstract-Vascular endothelial growth factor (VEGF) is important in improving wound healing. We evaluated the effect of sensory (direct current, 600 microamperes) and motor (monophasic current, pulse duration 300 microseconds, 100 Hz, 2.5-3.0 mA) intensities of cathodal electrical stimulation (ES) current to release VEGF in muscle and skin in the wound site. We randomly assigned 48 male Sprague-Dawley rats into one control and two experimental groups (sensory and motor ESs). A fullthickness skin incision was made on each animal's dorsal region. The experimental groups received ES for 1 h/day every other day. In the control group, no current was applied. VEGF expression was measured in muscle and skin on the third and seventh days after surgical incision. Our outcomes demonstrated that no difference was found in the VEGF levels among groups on the third day. However, on the seventh day, the skin VEGF levels in the sensory group were significantly higher than those levels of the other groups (p < 0.05). No difference was found in the muscle VEGF levels on the third and seventh days. The results showed that sensory ES increases the release of more VEGF in skin. This mechanism may be one through which a sensory type of current is more effective in promoting wound healing.

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Section: Wounding and Treatment Protocolmentioning

confidence: 99%

Effect of sensory and motor electrical stimulation in vascular endothelial growth factor expression of muscle and skin in full-thickness wound

Asadi¹,

Torkaman²,

Hedayati³

2011

JRRD

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“…6 In ani mal stu di es, US app li ca ti on with an in ten sity of 0.1-0.5 W/cm 2 with a fre qu ency of 1-3 MHz was shown to ac ce lera te the inf lam ma tory pha se of re pa ir. 3,26 For this re a son, in the pre sent study a si mi lar tre at ment pro to col was used (0.1 W/cm 2 with a fre qu ency of 1 MHz, 5 mi nu tes da ily).…”

Section: Discussionmentioning

confidence: 99%

“…Many in ves ti ga tors ag re e that app li ca ti on of US has be ne fi ci al ef fects on the inf lam ma tory pha se of re pa ir and this app li ca ti on can af fect the on set of pro li fe ra ti ve pha se. 3,26 Ho we ver, our fin dings and many ot hers did not sup port this ide a. 29,30 Bri efly, our re sult con cer ning the lack of ef fi cacy of US tre at ment on wo und he a ling is in ag re e ment with the ot hers pre vi o usly do cu men ted si mi lar nega ti ve re sults [7][8][9] On the ot her hand, it must be kept in mind that we might ha ve be en mis sed the an tiinf lam ma tory ef fect that had be en ta ken pla ce in the first 7 days.…”

Section: Discussionmentioning

confidence: 99%

Low-Level Laser Therapy is More Effective Than Pulse Ultrasound Treatment on Wound Healing: Comperative Experimental Study

Tıkız¹,

Angın²,

Demireli³

et al. 2010

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : To investigate and compare the effects of pulse ultrasound (US) and lowlevel laser therapy (LLLT) on wound healing. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Thirty-two rats were included in the study and two full-thickness skin wounds were made on dorsum area of the rats bilaterally, with a 17 mm hole-punch. The animals were divided into two groups. Pulsed US (with a power of 0.1 W/cm 2 , a frequency of 1 MHz, 5 minutes daily) was applied to to the right sided wounds of Group A (n= 16) and Ga-As laser (830 nm wavelength, 0.5 J/ cm 2 dosage of 1 MHz frequency for 1 minute duration) was applied to right sided wounds of Group B (n= 16). Left sided wound were considered as controls and same procedures were applied without any current (sham). Biochemical and histopathological evaluations were performed in each group on 7 th and 15 th days. R Re es su ul lt ts s: : Inflammatory cells tended to decrease in both treatment groups on the 7 th day, however, this finding did not reach a statistical significance (p> 0.05). Fibroblasts and collagen were found to be significantly increased in the laser group when compared to the other group on the 7 th day (p< 0.05). Angiogenesis was found to be significantly increased only in the laser group when compared to the other group on the 15 th day (p< 0.05). There were no significant differences in tissue nitric oxide values between the groups although the values in the laser group tended to be higher on the 15th day (p=0.058) C Co on nc cl lu us si io on n: : In this comparative study, LLLT was found to significantly accelerate mainly proliferative phase while pulse US had no effect on wound healing. Our results support the consideration that LLLT may constitute a beneficial treatment modality for wound healing.K Ke ey y W Wo or rd ds s: : Laser therapy, low-level; ultrasonography; wound healing Ö ÖZ ZE ET T A Am ma aç ç: : Yara iyileşmesinde düşük enerjili lazer tedavisi (DELT) ve kesikli ultrason (US) tedavilerinin etkinliklerini incelemek ve karşılaştırmak. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya 32 rat dahil edildi ve deneklerin dorsal bölgesinde bilateral olarak tüm deri tabakalarını kapsayan 17 mm çapında iki yara oluşturuldu. İki gruba ayrılan deneklerin ilk grubunun (Grup A, n= 16) sağ taraftaki yaralarına kesikli US (1 MHz başlık ile 0.1 W/cm 2 şiddetinde, 5 dakika süreyle) uygulanırken ikinci gruba (Grup B, n= 16) DELT (830 nm dalga boyunda 0.5 j/cm 2 dozunda %50 şiddetinde, 1 dakika süreyle) uygulandı. Sol taraftaki yaralar kontrol olarak alındı ve tedaviler aynı şekillerde ancak ışın verilmeksizin uygulandı (sham). Yedinci ve 15. günlerde sakrifiye edilen deneklerde biyokimyasal ve histopatolojik değerlendirmeler yapıldı. B Bu ul lg gu ul la ar r: : Inflamatuvar hücrelerin yedinci günde her iki tedavi grubunda da azalmış olduğu, ancak istatiksel anlamlılığa ulaşmadığı gözlendi (p> 0.05). Bu dönemde yapılan histolojik incelemelerde fibroblast ve kollajen miktarının lazer g...

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“…Using a stimulator device (BTL 5000 series; BTL Industries, Ltd, United Kingdom), we applied microamperage DC ES with an intensity of 600 A, for 1 h/day, three times a week, for 3 weeks. These treatment parameters are used in many other studies [28][29]. In the control group, electrodes were similarly placed on the wound site but no current was applied.…”

Section: Treatment Protocolmentioning

confidence: 99%

Effect of anodal and cathodal microamperage direct current electrical stimulation on injury potential and wound size in guinea pigs

Talebi

Torkaman²,

Firoozabadi³

et al. 2008

JRRD

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Abstract-Injury potential may have a regulatory role in the wound healing process, and exogenous electrical stimulation (ES) may mimic natural endogenous bioelectric current that can improve wound healing. Until now, the influence of externally applied ES on injury potential has not been demonstrated during the healing of acute wounds. Thirty-nine male guinea pigs were randomly divided into a control group (sham treatment) and two experimental groups: anodal and cathodal direct current (DC). A 2.5 cm-long full-thickness skin incision was made on each animal's dorsal region. Differential skin surface potential was measured before and immediately after the injury and also through day 21 of the healing period; wound surface area (WSA) was also measured throughout the 21-day healing period. Immediately after injury, wound potential significantly increased in all three groups, reaching a maximum on day 1 for the control and cathodal groups and day 3 for the anodal group (p < 0.05), then decreasing through the healing period. Wound potential returned to preinjury levels by the end of the healing period in the anodal group only. By days 19 and 21, wound potential had decreased more for the anodal group than the control group (p < 0.05). By day 15 for the anodal group and day 17 for the cathodal group, WSA had decreased more compared with the control group (p < 0.05). Anodal microamperage DC ES is appropriate for improving the healing of acute skin wounds because it causes both the wound surface to close and the wound potential to return to preinjury levels faster.

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A Comparative Study of the Effect of Ultrasound and Electrostimulation on Wound Healing in Rats

Cited by 58 publications

References 20 publications

Effect of sensory and motor electrical stimulation in vascular endothelial growth factor expression of muscle and skin in full-thickness wound

Effect of sensory and motor electrical stimulation in vascular endothelial growth factor expression of muscle and skin in full-thickness wound

Low-Level Laser Therapy is More Effective Than Pulse Ultrasound Treatment on Wound Healing: Comperative Experimental Study

Effect of anodal and cathodal microamperage direct current electrical stimulation on injury potential and wound size in guinea pigs

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