A comparative study of the development of the fetal testis and ovary in the monkey (Macaca fascicularis)

Fouquet, J; Dang, D. C.

doi:10.1051/rnd:19800804

Cited by 13 publications

(12 citation statements)

References 33 publications

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“…The term gonocytes was further defined by Baillie in 1964 as the germ cells that ''persist in the testis from the formation of the sex cords until a few days after birth when they disappear'' [4]. Although the term gonocyte was designed to represent male germ cells, it is interesting to note that few investigators used it to identify female intragonadal fetal germ cells [5]. However, as fundamental differences in the fate of male and female fetal germ cells were unveiled, the term gonocytes became restricted to male germ cells.…”

Section: Historical Perspectivesmentioning

confidence: 99%

Gonocytes, from the Fifties to the Present: Is There a Reason to Change the Name?1

Culty

2013

Biology of Reproduction

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Historically, the precursor cells to spermatogonia have been identified as "gonocytes," a term created in the fifties to encompass fetal and neonatal germ cells from the time they become resident in testis primordia to the time they relocate at the basement membrane of the seminiferous cords and differentiate. During this period, spreading over several days in rodents and months in humans, germ cell morphology and central location within the cords remain relatively unchanged. Another common trait is the intensive DNA methylation taking place in fetal to neonatal gonocytes. It is only when they reach the periphery of the cords after birth that germ cells acquire the characteristic appearance of spermatogonia. Studies showed that fetal and neonatal germ cells undergo progressive developmental changes comprising three major phases, a fetal mitotic phase followed by a quiescent period during which most of DNA methylation occurs and a neonatal mitotic phase associated with migration to the basement membrane, morphological changes, and differentiation to spermatogonia. Efforts to associate a distinctive gene expression profile to each of these phases have failed, revealing instead gradual changes in gene and protein expression and the coexistence within each period of unsynchronized cells at different phases of development. In the seventies, the terms pre- or prospermatogonia appeared as alternatives for the term gonocytes, but the definition of these terminologies varied between studies. Thus far, the term gonocyte remains the most commonly used, corresponding to a specific location of the cells, morphological appearance, and functional traits, which are distinct from the prior and subsequent developmental phases. In view of the present knowledge, one could further distinguish gonocyte subsets by the prefixes M, Q, and T, describing, respectively, fetal mitotic, quiescent, and transitional neonatal mitotic/migratory gonocytes, in conjunction with emerging methods allowing better discrimination of these subsets.

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Section: Historical Perspectivesmentioning

confidence: 99%

Gonocytes, from the Fifties to the Present: Is There a Reason to Change the Name?1

Culty

2013

Biology of Reproduction

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“…They differ only from the conclusions of Dang and Fouquet (1979) and Fouquet and Dang (1980) who claim that the somatic cells of the gonadal blastema of the Macaca fascicularis monkey are derived from the stromal cells surrounding the mesonephric elements; and from those of Wartenberg (1978Wartenberg ( , 1979Wartenberg ( , 1981aWartenberg ( , 1982 who states that, in human embryos, the somatic cells of the gonad originate in part from the coelomic mesothelium and in part from the epithelial elements of involuting mesonephric glomeruli and tubules. The discrepancies between the results of our study and the observations made by these authors are not easy to explain.…”

Section: Discussionmentioning

confidence: 65%

The development of the sexually indifferent gonad in the prosimian, Galago crassicaudatus crassicaudatus

Yoshinaga

Hess

Hendrickx³

et al. 1988

Am. J. Anat.

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The morphogenesis of the sexually indifferent gonad of the primate Galago crassicaudatus crassicaudatus was studied by high-resolution light microscopy and electron microscopy in 15 embryos aged 26 to 33 days. Onset of gonadal development follows the morphogenesis of the mesonephros by a conspicuous interval and is identified as the time when the first primordial germinal cells arrive in the region ventral to the central third of the mesonephros; this is followed by intense proliferation of the coelomic mesothelial cells lining the area. They become organized into short piles that deepen in the underlying mesenchyme, enclosing the germinal cells in the process. Rapidly, the piles become confluent forming a compact mass, the gonadal blastema, which is soon cleaved into gonadal cords by stroma and vascular lacunae. The mesonephros becomes involved in the morphogenesis of the gonad only in late stages of development when anatomic continuities become established between the capsules of its regressing glomeruli and the elongating gonadal rete cords. These observations show that in the Galago the somatic cells of the gonadal blastema, i.e., the precursors of the definitive testicular and ovarian sustentacular cells, derive from the coelomic mesothelium in contrast to other mammals, e.g., ruminants and rodents, where they are of mesonephric derivation. This important point is discussed in light of the differences that exist among species with regard to the structural complexity, functionality, and stages of differentiation/involution of their mesonephroi on the one hand, and the time of gonadal development on the other.

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“…A diminuição gradativa dos cordões ovígeros parece ser uma caracterís-tica conservada ao longo do processo evolutivo e tem sido relatada em outras espécies de mamíferos, como por exemplo, em macacas (Fouquet & Dang 1980), ovelhas (Sawyer et al 2002), bovinos (Kenngott et al 2013) e seres humanos (Konishi et al 1986), bem como na espécie de codorna Coturnix coturnix japonica (Madekurozwa 2012).…”

Section: Discussionunclassified

“…A presença de aumento na espessura cortical encontrada em nosso estudo indica que a hipertrofia ovariana encontrada neste período gestacional, deva-se a uma modificação do órgão por inteiro e não só pela medula, embora tenhamos observado diminuição gradativa do tamanho das células intersticiais durante este período. A involução de tecido intersticial esteroidogênico também foi relatada por Fouquet & Dang (1980) na espécie Macaca fascicularis. O aumento do calibre dos vasos sanguíneos na medula também poderia explicar a hipertrofia ovariana citada por Hay & Allen (1975).…”

Section: Discussionunclassified

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Estudo de ovários fetais equinos: uma abordagem histológica1

et al. 2016

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RESUMO.-O estudo do desenvolvimento embriológico de órgãos reprodutivos representa uma ferramenta importante para a compreensão das particularidades da espé-cie equina, assim como ampliar os conhecimentos sobre o desenvolvimento de folículos antrais que podem ser utilizados para produção in vitro de embriões. O presente trabalho teve como objetivo descrever as alterações morfológicas de ovários fetais equinos ocorrentes durante o desenvolvimento gestacional. Foram utilizados fetos equinos provenientes de abatedouro. Imediatamente após o abate foi realizada medição da distância cefalococcígea para o cálculo da idade gestacional em dias (dias de gestação -DG) e dissecação dos fetos para a retirada e fixação dos ovários. Foram realizadas avaliações macroscópicas e histológicas

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A comparative study of the development of the fetal testis and ovary in the monkey (Macaca fascicularis)

Abstract: Summary. The Introduction.

Cited by 13 publications

References 33 publications

Gonocytes, from the Fifties to the Present: Is There a Reason to Change the Name?1

Gonocytes, from the Fifties to the Present: Is There a Reason to Change the Name?1

The development of the sexually indifferent gonad in the prosimian, Galago crassicaudatus crassicaudatus

Estudo de ovários fetais equinos: uma abordagem histológica1

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