A comparative study of the antioxidant and intestinal protective effects of extracts from different parts of Java tea (<i>Orthosiphon stamineus</i>)

Cai, Xuan; Xiao, Changhong; Xue, Huiqin; Xiong, Hui; Hang, Yiqiong; Xu, Jianxiong; Lu, Yonghong

doi:10.1002/fsn3.584

Cited by 35 publications

(40 citation statements)

References 20 publications

(34 reference statements)

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“…anthocyanins and proanthocyanidins and their biosynthesis is usually higher in berries than is (Giada et al, 2013). Based on the available literature (Zengin et al, 2015;Mena et al, 2018;Mollica et al, 2018;Cai et al, 2018), the chemical and biological approaches on different…”

Section: Polyphenolics Profilementioning

confidence: 99%

Comparative in vitro studies of the biological potential and chemical composition of stems, leaves and berries Aronia melanocarpa's extracts obtained by subcritical water extraction

Cvetanović

Zengin

Zeković

et al. 2018

Food and Chemical Toxicology

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Section: Polyphenolics Profilementioning

confidence: 99%

Comparative in vitro studies of the biological potential and chemical composition of stems, leaves and berries Aronia melanocarpa's extracts obtained by subcritical water extraction

Cvetanović

Zengin

Zeković

et al. 2018

Food and Chemical Toxicology

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“…We previously showed that OE protected the intestine against oxidative stress [6]. However, there are no reports confirming that RA is the predominant effective compound in the antioxidant activity of OE.…”

Section: Introductionmentioning

confidence: 99%

Rosmarinic Acid, the Main Effective Constituent of Orthosiphon stamineus, Inhibits Intestinal Epithelial Apoptosis Via Regulation of the Nrf2 Pathway in Mice

et al. 2019

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Many studies have shown that Orthosiphon stamineus extract (OE) has antioxidant activity, and we previously reported that OE protects the intestine against injury from a high-fat diet. However, the molecular mechanism underlying this protective effect of OE was unclear. Here, OE was separated according to polarity and molecular weight, and the antioxidant activity of each component was compared. The components with the highest antioxidant activity were analyzed by HPLC, which confirmed that rosmarinic acid (RA) was the main effective constituent in OE. OE and RA were then tested in a mouse high-fat diet-induced intestinal injury model. The antioxidant indices and morphological characteristics of the mouse jejunum were measured, and activation of the nuclear factor E2-related factor 2 (Nrf2) pathway and apoptosis of jejunal epithelial cells were analyzed. Of all the constituents in OE, RA contributed the most. Both RA and OE activated the Nrf2 pathway and increased downstream antioxidant enzyme activity. RA and OE protected the mouse intestine against high-fat diet-induced oxidative stress by preventing intestinal epithelial cell apoptosis via both extracellular and intracellular pathways. Thus, RA, the main effective constituent in OE, inhibits intestinal epithelial apoptosis by regulating the Nrf2 pathway in mice.

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“…Moreover, CSH was used as one of the predominant ingredients in “Xueniao'an granules,” which was a very popular traditional Chinese medicine prescription for the treatment of urolithiasis. Pharmacological studies have shown that CSH has antimicrobial, antioxidant, hepatoprotective, antigenotoxic, antiplasmodial, cytotoxic, cardioactive, antidiabetic and anti‐inflammatory activities . Polymeric phenolic acids, flavonoids, diterpenes, triterpenes, essential oils and polysaccharides have been isolated from CSH by phytochemical approaches .…”

Section: Introductionmentioning

confidence: 99%

“…shown that CSH has antimicrobial, antioxidant, hepatoprotective, antigenotoxic, antiplasmodial, cytotoxic, cardioactive, antidiabetic and anti-inflammatory activities. [2][3][4][5][6] Polymeric phenolic acids, flavonoids, diterpenes, triterpenes, essential oils and polysaccharides have been isolated from CSH by phytochemical approaches. [7][8][9][10][11] Published literature concerning CSH has mainly focused on the quantification of several phenolic acids or flavonoids by high-performance liquid chromatography-photodiode array detector method or high-performance liquid chromatography/ tandem mass spectrometry.…”

Section: Introductionmentioning

confidence: 99%

Characterization of polymeric phenolic acids and flavonoids in Clerodendranthi Spicati Herba using ultrahigh‐performance liquid chromatography coupled to quadrupole time‐of‐flight tandem mass spectrometry with target and nontarget data mining strategy

Luo

Wen

Lai

et al. 2019

Rapid Comm Mass Spectrometry

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Rationale Clerodendranthi Spicati Herba (CSH) is often used to treat urinary stones, urinary tract infections and nephritis in China. Much literature has reported that polymeric phenolic acids and flavonoids are the major bioactive components in CSH. Therefore, it is very meaningful to identify the polymeric phenolic acids and flavonoids in CSH. Methods Ultrahigh‐performance liquid chromatography coupled to quadrupole time‐of‐flight tandem mass spectrometry (UHPLC/QTOF‐MS/MS) analysis with target and nontarget data mining strategy was proposed to rapidly profile the polymeric phenolic acids and flavonoids in CSH. Diagnostic product ions and neutral loss filter were beneficial for identifying the polymeric phenolic acids and flavonoids from complex compounds in CSH. Results A total of 118 compounds, including 85 polymeric phenolic acids and 33 flavonoids, were reasonably identified in CSH by comparing their main fragmentation pathways with literature data, and 85 of them were discovered in CSH firstly by nontarget analysis. Nine potential compounds were characterized tentatively as new pentameric and hexameric phenolic acids in CSH. Six types of polymeric phenolic acids (monomer, dimer, trimer, tetramer, pentamer and hexamer) and four types of flavonoids (apigenin, kaempferol, luteolin and quercetin) were identified in CSH. Conclusions The results indicated that the UHPLC/QTOF‐MS/MS method coupled with target and nontarget data mining strategy was feasible and rational for identifying the polymeric phenolic acids and flavonoids in complex chemical constituents of CSH. The findings will be conducive to the discovery of the active ingredients of CSH and the establishment of quality standards.

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A comparative study of the antioxidant and intestinal protective effects of extracts from different parts of Java tea (Orthosiphon stamineus)

Cited by 35 publications

References 20 publications

Comparative in vitro studies of the biological potential and chemical composition of stems, leaves and berries Aronia melanocarpa's extracts obtained by subcritical water extraction

Comparative in vitro studies of the biological potential and chemical composition of stems, leaves and berries Aronia melanocarpa's extracts obtained by subcritical water extraction

Rosmarinic Acid, the Main Effective Constituent of Orthosiphon stamineus, Inhibits Intestinal Epithelial Apoptosis Via Regulation of the Nrf2 Pathway in Mice

Characterization of polymeric phenolic acids and flavonoids in Clerodendranthi Spicati Herba using ultrahigh‐performance liquid chromatography coupled to quadrupole time‐of‐flight tandem mass spectrometry with target and nontarget data mining strategy

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