1986
DOI: 10.1016/0041-008x(86)90202-4
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A comparative study of the effects of benzene, toluene, and xylenes on their in vitro metabolism and drug-metabolizing enzymes in rat liver

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Cited by 47 publications
(14 citation statements)
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“…However, these results are in contrast to those of Pyykk6 (1980) and Pathiratne et al (1986), who administered B or X by injection and found increased B, but not AN oxidation, although both are 2El substrates. These authors did not describe substrate levels and since enzyme induction becomes apparent at above Km and especially at near-saturation conditions, different assay conditions could be responsible for this discrepancy.…”
Section: Discussioncontrasting
confidence: 84%
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“…However, these results are in contrast to those of Pyykk6 (1980) and Pathiratne et al (1986), who administered B or X by injection and found increased B, but not AN oxidation, although both are 2El substrates. These authors did not describe substrate levels and since enzyme induction becomes apparent at above Km and especially at near-saturation conditions, different assay conditions could be responsible for this discrepancy.…”
Section: Discussioncontrasting
confidence: 84%
“…In previous reports, B or T exposure markedly induced B, but not T oxidation (Gut 1983;Pathiratne et al 1986), whereas in this study both pathways were stimulated to a similar extent. The difference between Gut (1983) (a single 24-h inhalation) and this paper (four 20-h exposures) may reflect the fact that 2El induction proceeds by enzyme or mRNA stabilization, and is therefore more rapid than P450 2B 1 induction, occurring via increased gene transcription.…”
Section: Discussioncontrasting
confidence: 79%
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