A comparative study of the thermal and dynamic mechanical behaviour of quenched and annealed bioresorbable poly-l-lactide/α-tricalcium phosphate nanocomposites

Wilberforce, Samuel I. J.; Finlayson, Chris E.; Best, Serena M.; Cameron, Ruth E.

doi:10.1016/j.actbio.2011.02.006

Cited by 32 publications

(22 citation statements)

References 36 publications

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“…It also has limitation in making homogeneous dispersion in stereocomplex matrix. The small improvement in Young's modulus was presumably supported by the stiffening effect of TCP materials [18]. Otherwise, s-PDLCL/g-TCPs show better improvement in Young's modulus.…”

Section: Resultsmentioning

confidence: 88%

Preparation and characterization of a stereocomplex of poly(lactide-co-ε-caprolactone)/tricalcium phosphate biocomposite using supercritical fluid technology

Nurqadar¹,

Purnama²,

Kim³

2013

Express Polym. Lett.

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Absorbable materials are attractive for internal fracture fixation devices. They have advantages in the reduction of stress shielding, secondary operations for removal are no longer required, and the risks of complications are reduced [1]. Biopolymers such as polylactide, poly(glycolic acid), poly(!-caprolactone), and their copolymers attract great attention due to their biodegradability and biocompatibility. The major limitation of those materials is that their mechanical properties (as strength, toughness, elastic modulus) are lower than the mechanical properties of cortical bones. Abstract. A novel biocomposite material from a stereocomplex of poly (L-lactide-co-!-caprolactone) (PLLCL) and poly (D-lactide-co-!-caprolactone) (PDLCL) and inorganic tricalcium phosphate (TCP) was prepared by supercritical fluid method. Both pristine and poly (L-lactide)-grafted-TCP (PLLA-g-TCP) were used. PLLA-g-TCP was produced by ringopening polymerization of L-lactide in the presence of surface-activated TCP. Infrared (IR) spectroscopy and scanning electron microscopic (SEM) images confirm the attachment of PLLA onto the activated TCP surface. The stereocomplex formation of biocomposite was confirmed by differential scanning calorimetry (DSC) and wide-angle X-ray diffraction (WAXD). The biocomposite containing PLLA-g-TCP has higher stereocomplex degree and more homogeneous TCP distribution compared to the biocomposite containing pristine TCP. The presence of PLLA-g-TCP in the stereocomplex PLLCL-PDLCL (s-PDLCL) enhance the stereocomplex degree up to a certain content and also supports the homogeneous TCP dispersion in the stereocomplex matrix. These phenomena support the improvement in mechanical properties of the s-PDLCL composite the optimum content of PLLA-g-TCP being 10%. The biocomposites containing TCP materials are promising materials for biomedical application, especially for bone tissue engineering.

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Section: Resultsmentioning

confidence: 88%

Preparation and characterization of a stereocomplex of poly(lactide-co-ε-caprolactone)/tricalcium phosphate biocomposite using supercritical fluid technology

Nurqadar¹,

Purnama²,

Kim³

2013

Express Polym. Lett.

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“…By doing so, antibiotics can be localized to a site of infection for treatment and possibly promote bone regeneration all without requiring a second surgery for release. 40,41 …”

Section: Biodegradable Delivery Systemsmentioning

confidence: 99%

“…In research completed by Wilberforce at el., 40 tricalcium phosphate (TCP) has also been studied by its combination in a crystalline polymer consisting of poly-L-lactide acid (PLLA) through a method known as twin screw extrusion. This method involves the melting and cycling of the PLLA and TCP for a period of time (in this case 15 min) before they are extruded through a strand die.…”

Section: Biodegradable Delivery Systemsmentioning

confidence: 99%

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The use of nanomaterials to treat bone infections

Snoddy

Jayasuriya

2016

Materials Science and Engineering: C

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A new era of osteomyelitis treatment has been taking strides towards efficient, local administration of antibiotics at the site of infection. By having them localized to the site of infection, this toxicity is no longer an issue and actually has shown to be a more productive treatment for osteomyelitis. Researchers have focused the production of non-biodegradable, antibiotic, infused bone cements specifically designed for proficient osteocyte binding, useful antibiotic release over a desirable period of time, and promotion of bone regeneration. These cements are then surgically placed on the infected site following debridement and irrigation. The problem, however, is that the use of ineffective cements and the overuse of antibiotics has led to the development of resistant bacteria. Due to this, further research is being done in the field of antibiotic discovery and delivery. Specifically, the development of biodegradable materials capable of efficiently delivering antibiotics and also eliminating the need for follow-up surgery to remove the delivery material is being done, thus reducing exposure risk. Nanoparticles have been developed in the forms of scaffolds and injections to deliver a higher degree and longer lasting duration of antibiotic release, while promoting bone regeneration.

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“…Despite the fact that there are a few reports dealing with the influence of filler content or preparation conditions on the properties of PLLA and its nanocomposites, data on the joint effects of these factors on composites based on PLLA and calcium phosphate ceramics intended for use in orthopedic applications are quite limited . Therefore, the intention of this work was to give a wide and complex depiction regarding the combined influence of the initial preparation conditions and filler content on the structure, crystallinity and thermal properties of PLLA and HAp/PLLA nanocomposites.…”

Section: Introductionmentioning

confidence: 99%

The influence of the preparation conditions and filler content on thermal properties of poly-l -lactide and hydroxyapatite/poly-l -lactide nanocomposite

Miličević

Suljovrujić

2017

Polym. Int.

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Poly‐l‐lactide (PLLA) and hydroxyapatite/poly‐l‐lactide (HAp/PLLA) are two widely used biomaterials for three‐dimensional scaffolds, drug release matrices and implantable medical devices for reparation of bone tissue; diversity in the initial preparation and filler content has a significant influence on different properties such as morphology and crystallinity, thus playing a considerable role in most of these applications. For this reason, PLLA and HAp/PLLA samples with a large difference in crystallinity (from below 20% to over 70%) and filler content (up to 86 wt% of HAp nanoparticles with an average diameter of 80 nm) were prepared and consequent dissimilarities in morphology, crystallinity and thermal properties were investigated by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), wide angle X‐ray diffraction (WAXD) measurements and Fourier transform infrared (FTIR) spectroscopy. Special attention was devoted to analyzing data obtained from thermal measurements. A three‐phase model was employed in order to describe the heat capacity step decline in the nanocomposite; the evolution in different polymer fractions, the crystalline fraction and the mobile and rigid amorphous fractions, with filler content was determined. © 2017 Society of Chemical Industry

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A comparative study of the thermal and dynamic mechanical behaviour of quenched and annealed bioresorbable poly-l-lactide/α-tricalcium phosphate nanocomposites

Cited by 32 publications

References 36 publications

Preparation and characterization of a stereocomplex of poly(lactide-co-ε-caprolactone)/tricalcium phosphate biocomposite using supercritical fluid technology

Preparation and characterization of a stereocomplex of poly(lactide-co-ε-caprolactone)/tricalcium phosphate biocomposite using supercritical fluid technology

The use of nanomaterials to treat bone infections

The influence of the preparation conditions and filler content on thermal properties of poly-l -lactide and hydroxyapatite/poly-l -lactide nanocomposite

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