A comparative study of the alkaloids ofCorydalis species

Margvelashvili, N. N.; Толкачев, О. Н.; Prisyazhnyuk, N. P.; Kir'yanova, A. T.

doi:10.1007/bf00567143

Cited by 2 publications

(1 citation statement)

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“…The other known compounds were identified through MS library matching techniques (NIST08s) and then confirmed through comparison of their melting point, optical rotation, mass and NMR spectra with those reported in the relevant literature. Compound 1 (950 mg) was identified as protopine [15][16][17], compound 4 (5 mg) as stylopine [15,[18][19][20], compound 5 (1 mg) as coreximine [21], compound 6 (1 mg) as rheagenine [10], compound 7 (60.6 mg) as ochrobirine [22][23][24][25], compound 8 (0.8 mg) as sibiricine [8,23] and compound 9 (9 mg) as bicuculline [26,27].…”

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Phytochemical and Biological Activity Studies of the Bhutanese Medicinal Plant Corydalis crispa

Wangchuk

Keller

Pyne

et al. 2012

Natural Product Communications

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The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. The phytochemical study resulted in the isolation of nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) and bicuculline (9), with complete NMR data for 2 and 3 provided here for the first time. Crude extracts exhibited significant anti-inflammatory (p<0.01) activity against TNF-α production in LPS activated THP-1 cells. The acetylcholinesterase inhibitory activity of compounds 2, 4 and 7 and the antiplasmodial activity of compound 5 against P. falciparum strains TM4/8.2 and K1CB1 (multidrug resistant strain) are reported here for the first time. Stylopine (4) did not show antimalarial activity against the K1CB1 strain in contrast to a previous report. This study generated a scientific basis for the use of this plant in Bhutanese traditional medicine, either individually or in combination with other medicinal ingredients to treat a broad range of disorders. This study also identified compound 5 as potential new antimalarial lead compound.

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